By PathGene Biotech · Technically reviewed by Alex Huang
PDRN Molecular Weight and Grade: What a Buyer Can Actually Confirm
Polydeoxyribonucleotide (PDRN, CAS 9007-47-4) is a DNA-derived polymer rather than a single small molecule. A buyer therefore needs to distinguish a batch-specific average molecular-weight result from a full molecular-weight distribution, and should not infer application suitability from purity alone.
What the current PathGene batches show
PathGene's medical-aesthetic batch PGPDRN-260408 reports an average molecular weight of <650 kDa / <1050 bp. That is the result and specification for that batch; it is not a claim that every PDRN lot has the same value or that it describes the complete distribution. The cosmetic-grade batch PGPDRN-260406 has its own specification and pH method. Keep the two grades and their COAs separate.
Why the distinction matters
Average molecular weight, fragment-size distribution, assay, residual protein and endotoxin answer different qualification questions. A COA that reports one average value cannot be rewritten as a distribution profile. Ask the supplier which method produced the value, whether it is batch-specific, and whether a distribution report is available for the intended formulation work.
What to verify from a supplier
- Identity and origin: confirm PDRN/CAS 9007-47-4 and the stated salmon-derived source for the offered grade.
- Grade and lot: match cosmetic or medical-aesthetic positioning, batch number, specification reference and storage condition across the quotation, sample and COA.
- Analytical basis: review UV identity (A260/A280), protein, assay basis, average molecular weight, endotoxin and microbiology results as separate fields.
- Distribution evidence: request SEC/GPC or another validated fragment-size report when the application depends on distribution rather than an average value.
Characterization methods are not interchangeable
UV can support identity review, HPLC can support assay review when the method is stated, and SEC/GPC or electrophoresis may answer molecular-size questions. Ask for the method, reference or calibration approach, sample preparation and whether the result is tied to the supplied lot. Do not use a general article or one batch result as a substitute for the current COA.
Application boundary
The current public documents support B2B qualification and formulation screening. They do not by themselves establish sterility, injectability, finished-product authorization or clinical performance. Confirm process, packaging, stability and local compliance separately for the finished formulation.
How PathGene documents this material
PathGene can provide the product specification and, where available, a batch-specific COA for the requested grade. Review the exact lot before approving a project, and ask for any additional distribution or stability data needed for the intended use.
EU cosmetics compliance checkpoint
The European Commission's CosIng inventory is a useful official lookup for cosmetic ingredient names and functions, but an inventory entry is not an authorization for a finished product or a claim that a raw material is approved for every use. Check the exact INCI identity, target market notification and finished-formula obligations with the responsible person before publication: European Commission CosIng.
Related sourcing resources: Review the product specification before requesting a sample.
For batch documentation and release checks, see our quality and analytical documentation.
Frequently Asked Questions
Why is an average molecular-weight result not the same as a distribution profile?+
An average is one summary value for a specified lot. A distribution report describes the spread and method behind the fragment-size population; ask for both when the application requires it.
What is the source and grade boundary for PathGene PDRN?+
The product is salmon-derived and is offered with cosmetic or medical-aesthetic positioning. Confirm the requested grade and its own batch COA; one grade's result must not be used for the other.
Which PDRN COA fields should a buyer review?+
Review identity, UV ratio, protein, assay basis, average molecular weight, endotoxin, microbiology and storage as separate fields, then request distribution data if the use case depends on it.
Does a PDRN grade label prove injectable suitability?+
No. A grade label does not by itself establish sterility, injectability, finished-product authorization or clinical performance. Confirm the complete regulatory and technical package for the intended market.
Can I request a batch COA before ordering?+
Yes. Request the COA for the exact grade and lot under review, and make sure its specification, methods and storage information match the quotation and sample.
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