PDRN
Polydeoxyribonucleotide
Key Specifications
| CAS Number | 9007-47-4 |
| Purity | ≥95.0% |
| Molecular Formula | Polymer |
| Molecular Weight | 50–1500 kDa |
| Appearance | White lyophilized powder |
| Solubility | Soluble in water |
| Storage | 2–8°C, protect from light |
| Shelf Life | 24 months |
CAS 9007-47-4
What Is PDRN?
Polydeoxyribonucleotide (PDRN, CAS 9007-47-4) is a biopolymer composed of chains of deoxyribonucleotides — short-to-medium fragments of double-stranded DNA — with a broad molecular weight distribution typically spanning 50-1500 kDa. DNA of this type occurs naturally in the cell nuclei of all living organisms; commercial bulk PDRN is conventionally produced from the milt (sperm) of salmon or trout, a fish-processing byproduct whose DNA sequence and base composition are highly homologous to human DNA, supporting good biocompatibility. At industrial scale, the raw genetic material is extracted, purified to remove proteins and other cellular residues, and controllably depolymerized to the target fragment-length range, then sterile-filtered and lyophilized into a stable white powder suitable for cosmetic and pharmaceutical-grade formulations.
Other Names
Key Features
High Assayed Purity
Each batch is assayed at ≥95.0% purity by HPLC, meeting the specification threshold required for cosmetic-grade and pharmaceutical-intermediate applications.
Controlled Depolymerization Process
A tightly monitored enzymatic/controlled depolymerization step keeps the DNA fragment population within the 50-1500 kDa target window, supporting batch-to-batch molecular weight consistency.
Stable Lyophilized Form
Supplied as a white lyophilized powder that is fully water-soluble, offering good handling stability and a long shelf life under recommended storage conditions.
Full Contaminant Screening
Every lot is screened for heavy metals (Pb, Hg, Cd, As) and microbial limits (total plate count, yeast & mold, E. coli, Salmonella) to support downstream regulatory documentation.
Flexible Bulk & OEM Supply
Available in flexible bulk packaging with OEM/private-label and custom concentration or blend support for cosmetic formulators and finished-product brands.
| Molecular Formula | Polymer |
| Molecular Weight | 50–1500 kDa |
| Appearance | White lyophilized powder |
| Solubility | Soluble in water |
| Storage Condition | 2–8°C, protect from light |
| Shelf Life | 24 months |
| Grade 1 | Pharma/Cosmetic Grade · ≥95.0% · COA |
End-Product Applications
Mechanism & Benefits
Promotes cell repair and regeneration, anti-inflammatory, supports wound healing and skin damage improvement.
Packaging Options
10 g 50 g 100 g
Lead Time
10–14 business days
Minimum Order
10 g
Custom Packaging
Custom packaging (foil bags, HDPE drums), GMP labeling, and export documentation are available. Contact us for specifics.Certifications
ISO
ISO
ISO9001
ISO 9001
Manufacturing Process
Raw Material Sourcing & Pretreatment
Milt (sperm) tissue from salmon or trout, a fishery processing byproduct, is collected, cleaned, and homogenized as the starting biological raw material.
Cell Lysis & DNA Extraction
Cells are lysed and native high-molecular-weight DNA is released and separated from proteins, lipids, and other cellular debris.
Deproteinization & Primary Purification
Repeated deproteinization, precipitation, and filtration steps remove residual protein and RNA to obtain a purified DNA intermediate.
Enzymatic/Controlled Depolymerization
The purified DNA is subjected to a controlled enzymatic or physical depolymerization step that fragments the polymer to the target 50-1500 kDa molecular weight distribution.
Chromatographic Purification & Endotoxin Removal
Chromatography and further precipitation cycles refine the fragment profile and reduce endotoxin and trace protein/RNA to specification.
Sterile Filtration & Concentration
The purified solution is sterile-filtered and concentrated in preparation for drying.
Freeze-Drying (Lyophilization)
The concentrate is freeze-dried under controlled vacuum conditions to yield a stable white lyophilized powder.
QC Testing, Milling & Release
Finished powder is milled/homogenized for uniformity, then tested for purity, molecular weight distribution, heavy metals, and microbial limits before batch release.
Quality Specifications
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White lyophilized powder | Conforms |
| Odor | Odorless or faint characteristic odor | Conforms |
| Solubility | Soluble in water | Conforms |
| Assay (Purity, HPLC) | ≥95.0% | 96.5% |
| Molecular Weight (Mw) | 50-1500 kDa | Within range (~600 kDa avg.) |
| Loss on Drying | ≤8.0% | 4.8% |
| pH (1% aqueous solution) | 6.0-8.0 | 7.1 |
| Lead (Pb) | ≤2 mg/kg | <1 mg/kg |
| Mercury (Hg) | ≤1 mg/kg | <0.1 mg/kg |
| Cadmium (Cd) | ≤1 mg/kg | <0.1 mg/kg |
| Arsenic (As) | ≤2 mg/kg | <1 mg/kg |
| Total Plate Count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mold | ≤100 CFU/g | <10 CFU/g |
| Pathogens (E. coli / Salmonella) | Negative/25g | Negative |
Purity & Assay Method
Purity is determined by reverse-phase or ion-exchange HPLC referenced against a characterized PDRN standard, typically supported by UV absorbance (A260) ratios and SEC/GPC-based molecular weight distribution analysis. Buyers should request the batch Certificate of Analysis and confirm the exact assay method, the reported molecular weight range, and residual protein/RNA and endotoxin levels against their own formulation or regulatory requirements before large-volume procurement.
Solubility & Formulation
PDRN is readily soluble in water, forming a clear to slightly opalescent solution suitable for aqueous cosmetic formulations, hydrogel systems, and injectable-grade preparations (subject to the appropriate pharmaceutical-grade sourcing and sterility processing). Because solution viscosity and stability are influenced by molecular weight distribution, pH, and ionic strength, formulators are advised to evaluate reconstitution conditions, buffer compatibility, and cold-chain or refrigerated storage of finished solutions to preserve fragment integrity and product performance.
Available Product Forms
Bulk PDRN Powder
High-purity raw material for cosmetic formulators, contract manufacturers, and ingredient distributors.
PDRN Solution / Premix
Custom-concentration aqueous or carrier-based premix for easier incorporation into finished formulations.
Custom Formulation Support
Formulation guidance for incorporating PDRN into serums, creams, or masks based on the intended finished product.
How is the ≥95.0% purity specification verified?+
Purity is confirmed by HPLC against a reference standard, with each batch accompanied by a Certificate of Analysis. Buyers may also request supplementary UV or SEC/GPC molecular weight data for independent confirmation.
What is PDRN made from, and how is it produced?+
Our PDRN is produced from salmon/trout milt DNA through extraction, deproteinization, controlled enzymatic depolymerization to the target 50-1500 kDa range, chromatographic purification, sterile filtration, and lyophilization.
Is PDRN water-soluble, and how should it be handled in formulation?+
Yes, PDRN is soluble in water. We recommend controlled reconstitution and cold storage of prepared solutions, as fragment integrity can be sensitive to pH, ionic strength, and temperature.
Can I request a sample before placing an order?+
Yes, small trial samples are available for formulation evaluation and in-house testing prior to bulk commitment. Please contact our sales team with your intended application for sample arrangement.
Is third-party testing available for each batch?+
Third-party test reports (e.g., purity, heavy metals, microbial limits) can be arranged for qualifying order volumes upon request; please discuss testing scope and turnaround with our sales team.
Do you offer OEM or private-label supply?+
Yes, we support OEM/private-label supply, including custom concentration, blending with complementary actives, and customized documentation to fit your brand requirements.
What packaging options are available?+
Standard bulk packaging (e.g., foil bags or drums with double-layer moisture protection) is available, with flexible packaging sizes and formats to accommodate different order volumes.
What is the MOQ, and how do I request a quotation?+
MOQ varies by packaging format and intended use; please contact our sales team with your target volume, application, and destination country to receive a tailored quotation.
Why Choose PathGene
- Direct China manufacturer supply — factory pricing, no middleman
- Batch-specific COA & full traceability on every shipment
- In-house R&D + synthetic biology / enzymatic production platform
- Free sample for qualified B2B buyers before commercial order
- Flexible MOQ — from lab-scale trial to ton-scale commercial supply
- One-stop OEM/private-label support for finished dosage forms
- Worldwide shipping by courier, air freight, and sea freight
OEM & Private-Label Services
- ·Custom capsule manufacturing
- ·Custom tablet manufacturing
- ·Powder blending & custom formulation
- ·Private-label bottles, pouches & labels
- ·Small trial orders
- ·Bulk commercial production
- ·Export documentation
- ·Third-party laboratory testing
Documents Available
- ·Certificate of Analysis (COA)
- ·Product specification sheet
- ·Material Safety Data Sheet (MSDS)
- ·Manufacturing flow chart
- ·HPLC test report
- ·Heavy-metal test report
- ·Microbiological test report
- ·Non-GMO / allergen statement
- ·Country-of-origin documentation
- ·Packing list & commercial invoice
Certificate availability should be confirmed with our sales team before ordering.
Sample Certificate of Analysis
PathGene Biotech Co., Ltd.
南京派琪生物科技有限公司
CERTIFICATE OF ANALYSIS
Layout example — not an issued batch record
Product Name
PDRN
CAS No.
9007-47-4
Batch No.
PG-SAMPLE-000000
Packaging
Issued upon order confirmation
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White lyophilized powder | Conforms |
| Odor | Odorless or faint characteristic odor | Conforms |
| Solubility | Soluble in water | Conforms |
| Assay (Purity, HPLC) | ≥95.0% | 96.5% |
| Molecular Weight (Mw) | 50-1500 kDa | Within range (~600 kDa avg.) |
| Loss on Drying | ≤8.0% | 4.8% |
| pH (1% aqueous solution) | 6.0-8.0 | 7.1 |
| Lead (Pb) | ≤2 mg/kg | <1 mg/kg |
| Mercury (Hg) | ≤1 mg/kg | <0.1 mg/kg |
| Cadmium (Cd) | ≤1 mg/kg | <0.1 mg/kg |
| Arsenic (As) | ≤2 mg/kg | <1 mg/kg |
| Total Plate Count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mold | ≤100 CFU/g | <10 CFU/g |
| Pathogens (E. coli / Salmonella) | Negative/25g | Negative |
Conclusion: Conforms to internal quality specifications
The COA issued with your order will carry the actual batch number, manufacture/test dates, and QC signature.
Related Products
Interested in PDRN?
Our R&D team will respond to your inquiry or sample request within 24 hours.
