Ceramide
CAS 100403-19-8
Purity≥95.0%
Ceramide lipid for skin-barrier and cosmetic formulation work
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore personal-care ingredients.
Confirm ceramide type, lipid profile and dispersion conditions.
Key Specifications
| Product Positioning | Ceramide lipid for skin-barrier and cosmetic formulation work |
| Application Scenarios | skin-barrier cream development · lipid dispersion screening · cosmetic stability testing |
| CAS Number | 100403-19-8 |
| Purity | ≥95.0% |
| Molecular Formula | Mixture |
| Molecular Weight | ~580 g/mol |
| Appearance | White to off-white powder or waxy solid |
| Solubility | Soluble in organic solvents |
| Storage | Room temperature, dry |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Ceramide (CAS 100403-19-8), commercially known as Ceramide 3 or Ceramide NP, is a sphingolipid consisting of an N-acylated phytosphingosine — primarily N-(tetracosanoyl)-phytosphingosine — with a representative formula near C36H73NO4 and molecular weight of about 580 g/mol. Because commercial material contains several closely related long-chain ceramide homologs, it is registered and supplied as a mixture rather than a single pure structure. This ceramide type occurs naturally in the stratum corneum, the outermost skin layer, where it helps organize the intercellular lipid lamellae that form the skin's barrier. Commercial bulk material is not extracted from animal or plant tissue but produced biotechnologically: a sphingoid-base precursor is generated by yeast fermentation, then acylated with a long-chain fatty acid, chemically or enzymatically, to build the ceramide, which is purified into a white to off-white powder or waxy solid.
High & Consistent Purity
Supplied at ≥95.0% purity as verified by HPLC, with tight batch-to-batch consistency supported by a rigorous internal quality management system.
Controlled Biotechnological Production
Produced via a fermentation and enzymatic-acylation platform rather than animal or plant extraction, giving full traceability over the sphingoid-base precursor and fatty-acid coupling step.
Uniform Powder/Waxy Solid Form
Delivered as a white to off-white powder or waxy solid with controlled particle size, allowing consistent dispersion in creams, emulsions, and other topical formulations.
Rigorous Contaminant Testing
Every batch is screened for heavy metals (Pb, Hg, Cd, As) and microbial limits (total plate count, yeast/mold, E. coli, Salmonella) to meet cosmetic raw-material safety expectations.
Flexible Bulk & OEM Supply
Available in flexible bulk packaging with OEM/private-label documentation support, custom COAs, and technical assistance for formulation trials.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGNP2-260504
Test date
Specification
In-house
Pack size
25kg/drum
Storage
Room temperature, dry
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white powder or waxy solid | Conforms |
| Odor | Odorless to faint characteristic odor | Conforms |
| Assay (Ceramide content, HPLC) | ≥95.0% | 96.8% |
| Melting point / crystal form | Waxy solid, approx. 60-90°C softening range | Conforms |
| Particle size | Micronized powder, D90 ≤75 μm (typical) | Conforms, D90 ≤75 μm |
| Loss on drying | ≤1.0% | 0.4% |
| Heavy metals - Lead (Pb) | ≤10 mg/kg | <5 mg/kg |
| Mercury (Hg) | ≤1 mg/kg | <0.1 mg/kg |
| Cadmium (Cd) | ≤1 mg/kg | <0.5 mg/kg |
| Arsenic (As) | ≤2 mg/kg | <1 mg/kg |
| Total plate count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mold | ≤100 CFU/g | <10 CFU/g |
| E. coli | Negative/25g | Negative |
| Salmonella | Negative/25g | Negative |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
Tablets
Facial serums
Creams and lotions
Cleansing products
This combination supports a multi-pathway beauty-from-within concept spanning epidermal lipids, dermal matrix proteins and hydration-associated polysaccharides.
Evidence: A multi-ingredient supplement study reported improved hydration, but the contribution of ceramides alone and exact synergy cannot be isolated.Source
These are major classes of stratum-corneum lipids and are commonly assembled into barrier-oriented creams and lotions. Ratio, lamellar structure and delivery system require formulation validation.
Evidence: Topical evidence generally concerns complete lipid systems, not isolated ceramide; finished-product testing is required.Source
Literature-Supported Research Directions
A 12-week randomized double-blind placebo-controlled study in 30 healthy adults evaluated wine-lees-derived ceramides and glucosylceramides. TEWL was lower than placebo at week 12, while secondary endpoints were not significantly different. The study was small and sponsor employees authored the paper.
Citation: Sanjaya et al., Nutrients 16 (2024), 2100. PMID: 38999848.View source
A split-site randomized controlled study in 24 participants compared a moisturizer containing ceramides 1, 3 and 6-II with hydrophilic cream. Hydration, TEWL and skin pH improved on the ceramide-treated side. The result applies to the complete formulation, not an isolated raw material.
Citation: Chang et al., International Journal of Dermatology 57 (2018/2019 record). PMID: 31585489.View source
A small double-blind randomized crossover trial in 16 participants with xerostomia symptoms evaluated pineapple glucosylceramide tablets and reported improvements in oral moisture and dryness ratings. This specific glucosylceramide preparation should not be treated as equivalent to every ceramide grade.
Citation: Nishimura et al., Nutrients 11 (2019). PMID: 31466334.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
100 g
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Yeast Strain Fermentation
A selected non-conventional yeast strain (Wickerhamomyces/Pichia ciferrii type) is fermented under controlled conditions to biosynthesize and secrete a tetraacetylated sphingoid-base precursor (TAPS) into the culture broth.
Broth Separation & Extraction
Biomass is removed from the fermentation broth and the secreted precursor is extracted and concentrated using solvent extraction and separation techniques.
Deacetylation to Phytosphingosine
The tetraacetylated intermediate is hydrolyzed (deacetylated) under controlled conditions to yield free phytosphingosine, the core sphingoid backbone of the final ceramide.
Precursor Purification
Crude phytosphingosine is purified by crystallization and/or chromatographic polishing to remove residual fermentation by-products before the acylation step.
N-Acylation with Fatty Acid
Purified phytosphingosine is coupled with a long-chain saturated fatty acid, using either lipase-catalyzed enzymatic amidation or a coupling-reagent-mediated chemical route, to form the ceramide amide bond.
Crude Product Crystallization
The crude ceramide reaction mass is crystallized from solvent to isolate the target ceramide and its closely related long-chain homologs from unreacted starting materials.
Purification & Drying
The crystallized material undergoes further washing/recrystallization and controlled drying to reach the target purity and residual solvent specifications.
Milling, QC & Packaging
The dried solid is milled or micronized to the target particle size, tested against full quality specifications, and packaged under controlled conditions for bulk or OEM supply.
Purity is determined by HPLC, typically with evaporative light-scattering or charged-aerosol detection, quantifying the target ceramide against closely related long-chain homologs and residual phytosphingosine or free fatty acid. Because this product is registered as a mixture, buyers should request the batch-specific certificate of analysis (COA) and, where formulation performance is critical, confirm the ceramide homolog ratio, residual solvent levels, and HPLC chromatogram rather than relying on the headline purity figure alone.
Commercial ceramide products span oral capsules/tablets and topical serums, creams, lotions and cleansers. Exact ceramide species, source and carrier system materially affect dispersion and performance; verify identity, lipid-phase compatibility, particle size and finished-product stability.
Each batch ships with a certificate of analysis (COA) showing HPLC-based purity, appearance, particle size, heavy metals, and microbial results. We can also provide the underlying HPLC chromatogram on request so you can verify results independently before purchase.
No. Our ceramide is produced through a biotechnological route: a sphingoid-base precursor is generated by yeast fermentation, then coupled with a long-chain fatty acid via enzymatic or chemical acylation. It is not extracted from animal tissue, which supports batch traceability and a more consistent supply.
It is not water-soluble; it dissolves in organic solvents and warm oil phases. Most formulators pre-disperse it as a lamellar/liposomal system or incorporate it into the heated oil phase, often alongside cholesterol and fatty acids. Our technical team can advise on formulation approaches for your specific application.
Yes, small samples are available for formulation trials and quality evaluation. Please contact our sales team with your intended application so we can recommend the appropriate grade and packaging.
Yes. In addition to our in-house COA, customers are welcome to submit samples to an independent laboratory of their choice for verification of purity, heavy metals, or microbial limits.
Yes, we support OEM/private-label supply, including customized documentation, labeling, and packaging sizes, as well as formulation support for finished cosmetic products built around this ceramide.
Standard packaging typically includes options such as 1 kg, 5 kg, and 25 kg fiber drums or bags with inner moisture-barrier liners; other package sizes can be arranged on request.
MOQ depends on packaging format and intended use; sample-scale quantities are generally accessible, while bulk pricing improves at drum-scale volumes. Please contact our sales team with your target quantity, application, and destination for a formal quotation.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
A formulation-focused guide to screen PDRN, GHK-Cu, and ceramide ingredients for serums, creams, masks, and other personal-care formats without turning preliminary science into finished-product claims.
Skincare formulators often shop for "ceramide" the way they'd shop for a small-molecule active with one fixed structure. The reality is closer to shopping for an oil blend — the ratio of components determines what you're actually formulating with.
Related Products
PDRN Powder (Polydeoxyribonucleotide)
GHK-Cu Powder (Copper Tripeptide-1)
Interested in Ceramide?
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Alex Huang · Mon–Fri 9am–6pm CST
