By PathGene Biotech · Technically reviewed by Alex Huang
PQQ Disodium Bulk Supplier Guide: Assay, Batch COA, Stability and Documentation
Short answer
When purchasing bulk PQQ, first confirm that the material is pyrroloquinoline quinone disodium salt (CAS 122628-50-6), then review the agreed assay basis and the actual lot COA. For a supplement project, the quality review normally also includes identity, related substances where specified, water, elemental impurities, microbiology, packaging, light protection, and traceability. A website purity headline is not a substitute for the release data of the lot being shipped.
1. Which questions should a PQQ buyer ask before quotation?
| Buyer question | Why it matters | What to request |
|---|---|---|
| Is this the disodium salt? | PQQ and PQQ disodium are not interchangeable names for a purchase order. | Product name, CAS number, molecular formula and identity method. |
| What does the assay mean? | Assay may be reported on an as-is or dry basis; comparison requires the same basis. | Specification, COA result, water result and method reference. |
| How is the batch protected? | PQQ is redox-active and the commercial material is commonly protected from light. | Storage statement, inner packaging and shipping instructions. |
| Does the COA fit the intended use? | Supplement, food, research and diagnostic projects can have different acceptance criteria. | Actual lot COA, SDS, specification and target-market requirements. |
2. Read the COA as a batch document
Match the lot number on the COA to the label and shipping records. Confirm the identity test, assay limit and result, water or loss-on-drying result, appearance, and the test methods or method references. Elemental-impurity and microbiology limits should be agreed for the actual application rather than assumed from another grade. FDA dietary-supplement CGMP guidance requires component specifications and, when a manufacturer relies on a supplier COA, documented supplier qualification and periodic reconfirmation of its reliability.
3. Why storage and formulation screening belong in supplier qualification
PQQ is a redox-active compound. Published analytical work distinguishes oxidized and reduced PQQ species and notes the analytical challenges created by redox instability and low solubility of the reduced form. This does not prove a finished-product benefit; it does mean a development team should define the assay approach, avoid uncontrolled light exposure, and run its own compatibility and shelf-life testing in the intended matrix. For water-based products, confirm pH, color, preservative compatibility and packaging during pilot work.
4. Practical documentation checklist
- Product specification stating the PQQ disodium identity and assay basis.
- Batch-specific COA matching the proposed shipment.
- SDS and storage/transport statement, including light protection.
- Elemental-impurity and microbiology data appropriate to the agreed use.
- Method summary or test-method references for a quality review.
- Country-of-origin, allergen or other declarations only where actually available and relevant to the target market.
Market and claim boundary
PQQ disodium salt has market-specific regulatory conditions. For example, the European Union has an authorisation pathway for PQQ disodium salt as a novel food under specified conditions; that does not establish approval, dosage, or claims in every country or for every finished product. The importer and finished-product owner should confirm the current requirements for the destination market.
Review PathGene PQQ
See the PQQ disodium product page for the current material profile and request a quotation or sample with the intended use, target market and desired documentation package.
References
FDA dietary-supplement CGMP small-entity guide; Qian et al., ACS Omega (2026), PQQ redox-species HPLC method; Commission Implementing Regulation (EU) 2018/1122.
Frequently Asked Questions
Is PQQ the same as PQQ disodium salt?+
They are related but should not be used interchangeably on a purchase order. Confirm the exact salt form, CAS number, identity method and assay basis.
Can a generic COA be used for supplier approval?+
No. Supplier qualification may use multiple documents, but the received or proposed shipment should be traceable to its own lot-specific COA.
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