PQQ
CAS 122628-50-6
Purity≥99%
Quinone cofactor material for nutrition and biochemical research
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore healthy-aging ingredients.
Confirm disodium-salt form and light/moisture controls.
Key Specifications
| Product Positioning | Quinone cofactor material for nutrition and biochemical research |
| Application Scenarios | quinone cofactor assays · nutrition powder development · mitochondrial research |
| CAS Number | 122628-50-6 |
| Purity | ≥99% |
| Molecular Formula | C₁₄H₄N₂O₈·2Na |
| Molecular Weight | 374.17 g/mol |
| Appearance | Dark red to dark brown powder |
| Solubility | Soluble in water |
| Storage | Room temperature, protect from light |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Pyrroloquinoline quinone disodium salt (PQQ disodium, CAS 122628-50-6) is the water-soluble sodium salt of PQQ, an aromatic tricyclic ortho-quinone that functions in nature as a redox cofactor for bacterial dehydrogenases (quinoproteins). With molecular formula C14H4N2O8·2Na and a molecular weight of 374.17 g/mol, it appears as a dark red to dark brown powder. PQQ occurs naturally at trace levels in soil, fermented foods, and some plant tissues, but commercial bulk material is not extracted from these sources; instead it is produced at scale by controlled microbial fermentation using methylotrophic bacteria (such as Hyphomicrobium species) grown on methanol, followed by broth clarification, purification, and conversion of the free acid into the more stable, water-soluble disodium salt form used in finished ingredients.
≥99% Assayed Purity
Every batch is quantified by validated HPLC assay to confirm purity of 98.0% or higher, with a certificate of analysis issued per lot.
Controlled Microbial Fermentation
Produced via monitored fermentation using methylotrophic bacteria (Hyphomicrobium), with strict process controls to ensure consistent yield and quality batch to batch.
Consistent Dark Red-Brown Powder
Supplied as a fine, free-flowing dark red to dark brown powder with uniform particle size, well suited for direct blending or downstream processing.
Heavy Metal & Microbial Screening
Each lot is screened for heavy metals (Pb, As, Hg, Cd) and microbial limits (total plate count, yeast/mold, E. coli, Salmonella) to support food- and supplement-grade use.
Flexible Bulk & OEM Supply
Available in flexible order quantities from sample size to bulk drums, with OEM/private-label formulation, custom particle size, and tailored packaging on request.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGPQQ-260601
Test date
2026-06-22
Specification
In-house
Pack size
25 kg/carton
Storage
Room temperature, protect from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | Orange to reddish brown powder | Reddish brown powder |
| Identification | HPLC main peak retention time consistent with reference | Complies |
| Purity | ≥99.0% | 99.8% |
| Assay (dry basis) | ≥98.0% | 99.4% |
| Water | ≤12% | 9.5% |
| Lead (Pb) | ≤0.1 ppm | Complies |
| Mercury (Hg) | ≤0.1 ppm | Complies |
| Cadmium (Cd) | ≤0.2 ppm | Complies |
| Arsenic (As) | ≤0.1 ppm | Complies |
| Total microbial count | ≤500 CFU/g | <10 |
| Mold and yeast | ≤50 CFU/g | Complies |
| Coliform | Not detected | Complies |
| Staphylococcus aureus | Not detected | N.D |
| Salmonella | Not detected | N.D |
| Pseudomonas aeruginosa | Not detected | N.D |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
PQQ with selenium is an existing hard-capsule commercial format that combines a redox-active quinone with a micronutrient antioxidant-system component.
Evidence: Commercial-format evidence only. The available human PQQ studies do not establish a PQQ–selenium synergistic efficacy claim.Source
Literature-Supported Research Directions
PQQ is studied as a redox-active quinone associated with mitochondrial signaling and biogenesis-related pathways. Small human crossover studies reported changes in selected inflammation and metabolite markers, while standard clinical indices were not consistently changed.
Citation: Stites et al., Journal of Nutritional Biochemistry (2013): dietary PQQ and mitochondrial-related metabolism in humans.View source
PQQ can be used in cellular redox, oxidative-stress and mitochondrial-response models. The available human evidence is limited in size and duration, so finished-product claims should be supported by product-specific data.
Citation: Stites et al., Journal of Nutritional Biochemistry (2013).View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
100 g
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Strain Preparation & Seed Culture
A high-yield methylotrophic bacterial strain (Hyphomicrobium/Methylobacterium type) is revived from the strain bank and expanded through seed culture stages under sterile conditions.
Controlled Fermentation
Seed culture is transferred into production bioreactors with methanol as the primary carbon source; pH, dissolved oxygen, temperature, and feed rate are continuously monitored to maximize PQQ biosynthesis.
Broth Clarification
Bacterial cells and insoluble solids are removed from the fermentation broth by centrifugation and/or membrane filtration, yielding a clarified PQQ-containing liquid.
Adsorption & Extraction
The clarified liquid is passed through macroporous resin columns to selectively capture and concentrate PQQ, which is then eluted from the resin.
Chromatographic Purification
The eluate undergoes further purification (such as ion-exchange chromatography) to remove residual pigments, salts, and fermentation by-products, raising PQQ purity significantly.
Acidification & Crystallization
The purified solution is acidified to precipitate PQQ free acid, which is collected and washed to a high degree of purity.
Neutralization to Disodium Salt
PQQ free acid is neutralized with a sodium base (e.g., sodium hydroxide/sodium bicarbonate) under controlled conditions to form the more soluble and stable disodium salt.
Drying, Milling & Quality Control
The disodium salt is vacuum- or freeze-dried, milled to the target particle size, sieved, and released for packaging only after passing full quality control testing.
Purity is determined by reverse-phase HPLC with UV detection against a qualified PQQ reference standard, which reliably separates PQQ from residual fermentation by-products and degradation impurities. Buyers should request the batch-specific certificate of analysis, confirm the reference standard and detection wavelength used, and, for regulated end-uses, consider independent third-party verification alongside our in-house COA.
PQQ disodium salt is freely soluble in water, readily forming a clear, deep reddish-brown solution suitable for aqueous processing. Solutions are generally most stable near neutral pH; prolonged exposure to strong acids, high heat, intense light, or high concentrations of reducing agents such as ascorbic acid can accelerate degradation of the quinone structure, so co-formulation with such ingredients should be compatibility-tested in advance. It is commonly incorporated into capsules, tablets, powder blends, and beverage or liquid premixes, and can be considered for microencapsulation or protective coating in applications requiring extended shelf life.
Purity is verified by validated HPLC assay for every production batch, and a certificate of analysis (COA) is issued and available on request along with the corresponding batch number.
It is produced by microbial fermentation using methylotrophic bacteria (Hyphomicrobium), not chemical synthesis. The fermentation broth is purified and the resulting PQQ free acid is converted to the disodium salt for improved stability and solubility.
It is freely soluble in water. We recommend formulating near neutral pH, avoiding prolonged exposure to strong acids, high heat, or high levels of reducing agents like ascorbic acid, and pre-testing compatibility with your specific matrix.
Yes, small samples are available for evaluation upon request so you can verify appearance, solubility, and quality before committing to a bulk purchase.
Yes, in addition to our in-house COA, samples can be sent to a third-party laboratory of your choice for independent verification of purity and safety parameters.
Yes, we offer OEM and private-label options, including customized specifications (particle size, purity grade), formulation support, and branded packaging.
Standard packaging includes foil bags and fiber/plastic drums in sizes such as 1 kg, 5 kg, and 25 kg, with moisture-proof, light-protective packaging and custom sizes available on request.
MOQ varies depending on packaging format and customization needs; please contact our sales team with your target quantity and application to receive a formal quotation and lead time.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
A practical buyer guide to PQQ disodium identity, assay basis, lot COA review, light protection, microbial and elemental-impurity checks, and market-specific documentation.
If your marketing team builds finished-product claims around a random blog post that overstates what PQQ does, you inherit that regulatory risk — not the blog. Here's what's actually substantiated about PQQ, sourced honestly, so you can market it defensibly.
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