ERGO
CAS 497-30-3
Purity≥99.5%
Sulfur-containing antioxidant research material for nutrition and personal care
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore healthy-aging ingredients.
Confirm L-isomer identity and assay basis.
Key Specifications
| Product Positioning | Sulfur-containing antioxidant research material for nutrition and personal care |
| Application Scenarios | nutrition beverage screening · antioxidant formulation research · personal-care prototypes |
| CAS Number | 497-30-3 |
| Purity | ≥99.5% |
| Molecular Formula | C₉H₁₅N₃O₂S |
| Molecular Weight | 229.30 g/mol |
| Appearance | White crystalline powder |
| Solubility | Soluble in water |
| Storage | Store tightly closed in a dry place at room temperature, protected from light |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Ergothioneine (EGT, CAS 497-30-3) is a naturally occurring sulfur-containing amino acid derivative of histidine (C9H15N3O2S, MW 229.30 g/mol), structurally classified as a 2-thioimidazole betaine. It was first identified in the ergot fungus Claviceps purpurea and occurs naturally in select fungi (including many culinary mushrooms such as oyster, shiitake, and king oyster mushroom) and in Actinobacteria (e.g., Mycobacterium species); plants and animals cannot synthesize it themselves and instead accumulate it from dietary sources via a dedicated transporter. Commercial bulk ergothioneine is increasingly produced by microbial fermentation using engineered production strains (such as engineered bacteria, Corynebacterium glutamicum, or yeast) carrying the ergothioneine biosynthetic gene cluster, followed by cell lysis, purification, and crystallization to high purity, offering a more scalable and consistent alternative to mushroom extraction or multi-step chemical synthesis.
Ultra-High Purity (≥99.5%)
The release specification is ≥99.5% purity. The official COA for batch PGEGT-260602 recorded 99.9% purity and 100.5% assay on a dry basis; confirm the COA for the supplied batch before release.
Fermentation-Based Production Control
Produced via engineered microbial fermentation under tightly controlled bioprocess parameters (strain, media, temperature, pH), giving more consistent batch-to-batch quality than mushroom extraction or classical multi-step chemical synthesis.
Controlled Crystalline Appearance
The COA specification is white to off-white crystalline powder. Batch PGEGT-260602 was recorded as white crystalline powder, with a clear, colorless solution result under the stated test condition.
Comprehensive Release Controls
The official COA includes total impurities, loss on drying, ethanol residue, Pb/Hg/Cd/As and microbiological limits. Product suitability and regulatory compliance must still be assessed for each finished formulation and market.
Flexible Bulk & OEM Supply
Available in bulk quantities with flexible packaging and OEM/private-label support, including customized specifications, documentation (COA, MSDS), and packaging formats to match customer formulation and branding needs.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGEGT-260602
Test date
2026-06-03
Specification
In-house
Pack size
25 kg/carton
Storage
Store tightly closed in a dry place at room temperature, protected from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white crystalline powder | White crystal powder |
| Identification | IR spectrum concordant with reference | Complies |
| Solution clarity and color | Clear and colorless | Complies |
| Purity | ≥99.5% | 99.9% |
| Assay (dry basis) | 99.0%–101% | 100.5% |
| Total impurities | <0.8% | Complies |
| Loss on drying | ≤0.5% | 0.03% |
| Ethanol residue | ≤1000 ppm | N.D |
| Lead (Pb) | ≤3.0 ppm | Complies |
| Mercury (Hg) | ≤0.1 ppm | Complies |
| Cadmium (Cd) | ≤1.0 ppm | Complies |
| Arsenic (As) | ≤0.3 ppm | Complies |
| Total plate count | ≤1000 CFU/g | Complies |
| Yeast and mold | ≤100 CFU/g | Complies |
| Coliforms | Not detected | Complies |
| Staphylococcus aureus | Not detected | Complies |
| Salmonella | Not detected | Complies |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
Serum
Cream
Sheet masks
Ergothioneine is selectively transported by OCTN1 and studied in cellular antioxidant protection, while glutathione is a major intracellular redox system. The pair can be evaluated for oxidative-stress and cytoprotection formulations.
Evidence: This is primarily a mechanistic and review-based formulation direction; direct clinical evidence of synergy in finished products is not established. Redox compatibility, pH and storage stability should be tested.Source
Both ingredients can be considered in aqueous antioxidant systems for beverages, oral liquids and water-phase skin-care formulations. pH, metal ions and light exposure are key development variables.
Evidence: This is a formulation-development hypothesis, not proof of synergy. Vitamin C can change pH and the redox environment, so compatibility and stability data are required.Source
Ergothioneine is studied for skin oxidative and photo-stress responses, while ceramides are used in skin-barrier systems. The pair can be explored in serums, creams and sheet-mask formats.
Evidence: Evidence supports the individual research directions, not a guaranteed combination effect. Emulsion system, temperature, light and preservation compatibility must be verified.Source
Literature-Supported Research Directions
Pure ergothioneine is actively absorbed and retained in human blood. A controlled human study observed trends in oxidative-damage and inflammation biomarkers, although most changes were not statistically significant.
Citation: Cheah et al., Antioxidants & Redox Signaling (2017): uptake, metabolism and biomarkers after pure ergothioneine administration.View source
A randomized, placebo-controlled study of an ergothioneine-rich mushroom preparation reported improvements in selected skin-moisture, transepidermal-water-loss and wrinkle/texture measures. The study used a food preparation, so pure-ingredient and topical-formulation effects require separate validation.
Citation: Hanayama et al., Nutrients (2024): ergothioneine-rich Pleurotus preparation and skin functions.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
100 g
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Production Strain Preparation
An engineered microbial strain (e.g., engineered bacteria, Corynebacterium glutamicum, or yeast) carrying the ergothioneine biosynthetic gene cluster is recovered from seed stock and expanded through seed culture stages under aseptic conditions.
Fermentation
The seed culture is transferred into production bioreactors with optimized carbon, nitrogen, and sulfur sources; temperature, pH, dissolved oxygen, and feeding are controlled to drive intracellular biosynthesis and accumulation of ergothioneine.
Cell Harvest and Lysis
Fermentation broth is harvested and biomass is separated by centrifugation or filtration; cells are then disrupted (e.g., by high-pressure homogenization) to release intracellular ergothioneine into solution.
Clarification and Extraction
Cell debris and insoluble matter are removed by further centrifugation and/or membrane filtration, yielding a clarified extract enriched in ergothioneine.
Purification (Chromatography/Ion Exchange)
The clarified extract is purified using ion-exchange resins and/or chromatographic separation to remove residual proteins, salts, pigments, and process-related impurities.
Crystallization and Isolation
The purified solution is concentrated and crystallized under controlled conditions to yield ergothioneine crystals, which are then separated by centrifugation or filtration.
Drying, Milling and Quality Control
Crystals are dried, milled to the target particle size, and screened, with each batch tested against release specifications (purity, appearance, heavy metals, microbial limits) before packaging.
The official in-house COA records purity and dry-basis assay separately. Batch PGEGT-260602 recorded 99.9% purity and 100.5% assay on a dry basis. These are batch results, not a substitute for the COA of the material supplied to you.
Ergothioneine is freely soluble in water, making it well suited for aqueous-based formulations such as beverages, oral liquids, effervescent powders, and water-phase cosmetic emulsions and serums. Because it carries no strong odor or color, it can typically be incorporated without masking agents, though final products should be evaluated for compatibility with other actives, pH range, and heat exposure during processing to preserve stability and potency.
Our Ergothioneine (CAS 497-30-3) is supplied to a ≥99.5% purity release specification. The official COA for batch PGEGT-260602 recorded 99.9% purity; a batch-specific COA covering assay, appearance, impurities, heavy metals and microbiological limits is available for the material supplied.
Our Ergothioneine is manufactured using a microbial fermentation and enzymatic production platform, in which an engineered production strain synthesizes ergothioneine, which is then extracted, purified, and crystallized. This bio-based route offers more consistent, scalable, and traceable production compared with mushroom extraction or classical chemical synthesis.
Yes, Ergothioneine is freely soluble in water and works well in aqueous formulations such as beverages, oral liquids, and water-phase cosmetic products. We recommend confirming compatibility with your specific formulation pH and other actives during your own stability testing.
Yes, small samples are available on request so you can independently verify purity, appearance, and solubility before committing to a bulk purchase. Please contact our sales team with your intended application to arrange a sample.
Yes, we welcome customers to send samples or retained batch samples to their own qualified third-party laboratories for independent verification of purity, heavy metals, and microbial limits alongside our internal COA.
Yes, we support OEM and private-label programs, including customized packaging, labeling, and documentation, and can work with your team on specification requirements for finished dietary supplement or cosmetic products.
Standard packaging is typically 1 kg or 5 kg per aluminum foil bag or drum with double-layer protection against moisture and light; other packaging sizes and formats can be arranged to match your logistics and storage needs.
MOQ varies depending on packaging format and intended use; please contact our sales team with your target quantity and application to receive a formal quotation and lead-time estimate.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
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Alex Huang · Mon–Fri 9am–6pm CST
