NRHM
Nicotinamide Riboside Hydrogen Malate
Key Specifications
| CAS Number | 2415659-01-5 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₅H₂₁N₂O₁₀⁻ |
| Molecular Weight | 393.33 g/mol |
| Appearance | White to off-white powder |
| Solubility | Soluble in water |
| Storage | 2–8°C, protect from light and moisture |
| Shelf Life | 24 months |
CAS 2415659-01-5
What Is NRHM?
Nicotinamide Riboside Hydrogen Malate (NRHM, CAS 2415659-01-5) is a crystalline salt of nicotinamide riboside (NR), a pyridine nucleoside form of vitamin B3 that occurs naturally in trace amounts in milk and other foods. In NRHM, the NR cation (molecular formula C15H21N2O10-, MW 393.33 g/mol) is paired with a hydrogen malate counter-ion derived from L-malic acid rather than the chloride used in earlier NR salts. Commercial bulk NRHM is manufactured through a biosynthetic/enzymatic platform: nicotinamide and a ribose-derived glycosyl donor are enzymatically coupled to build the NR nucleoside, which is purified and then converted, via a controlled electrodialysis-based ion-exchange (desalination) process, into the low-moisture-uptake malate salt, followed by crystallization and drying to give a white to off-white powder of ≥98.0% purity.
Other Names
Key Features
Verified High Purity
Each batch is confirmed at ≥98.0% purity by HPLC against a validated reference standard, with a full certificate of analysis provided for every shipment.
Controlled Biosynthetic Production
Produced via an enzymatic coupling step and a patented electrodialysis desalination process, giving tight control over raw-material quality and final salt purity, batch after batch.
Low-Hygroscopicity Powder Form
Supplied as a free-flowing white to off-white powder with markedly lower hygroscopicity than chloride-form NR, simplifying storage, handling, and tableting.
Full Contaminant Screening
Every lot is screened for heavy metals (Pb, Hg, Cd, As) and microbial limits (total plate count, yeast & mold, E. coli, Salmonella) to meet food- and supplement-grade requirements.
Flexible Bulk & OEM Supply
Available in bulk quantities with customizable packaging, moisture-barrier aluminum bags, and OEM/private-label support for tablet, capsule, and powder-blend applications.
| Molecular Formula | C₁₅H₂₁N₂O₁₀⁻ |
| Molecular Weight | 393.33 g/mol |
| Appearance | White to off-white powder |
| Solubility | Soluble in water |
| Storage Condition | 2–8°C, protect from light and moisture |
| Shelf Life | 24 months |
| Grade 1 | Food/Supplement Grade · ≥98.0% · COA |
End-Product Applications
Typical Dosage
300–500 mg/serving
Compatible Formulations
compressed tablet, hard capsule, moisture-barrier sachet. Key advantage: ideal for products without nitrogen-flush packaging or tropical market distribution
Packaging Options
1 kg 5 kg 25 kg
Lead Time
5–7 business days
Minimum Order
1 kg
Custom Packaging
Custom packaging (foil bags, HDPE drums), GMP labeling, and export documentation are available. Contact us for specifics.Certifications
ISO
ISO
ISO9001
ISO 9001
Manufacturing Process
Biosynthetic Precursor Preparation
Ribose-derived glycosyl donor and nicotinamide precursor are prepared, with ribose typically sourced from microbial fermentation or enzymatic glucose conversion.
Enzymatic Glycosylation
A biocatalyst (a nucleoside phosphorylase/ribosyltransferase-type enzyme) couples nicotinamide with the activated ribose donor to construct the nicotinamide riboside (NR) nucleoside, initially isolated as an NR salt intermediate.
Reaction Workup and Primary Purification
The crude reaction mixture is clarified, decolorized with activated carbon, and concentrated to isolate the NR intermediate before salt conversion.
Electrodialysis Ion-Exchange (Desalination)
A patented membrane-based electrodialysis process removes the original counter-ion and exchanges it for hydrogen malate derived from L-malic acid, converting the intermediate into NRHM in solution.
Controlled Crystallization
Cooling or anti-solvent crystallization is used to precipitate NRHM in a defined crystal form associated with reduced moisture uptake.
Isolation and Drying
Crystals are separated by filtration or centrifugation and dried under controlled temperature and humidity to protect the moisture-sensitive product.
Milling and Particle Size Control
The dried material is milled and sieved to achieve a uniform particle size suited to direct compression, capsule filling, and powder blending.
Quality Control and Packaging
Each batch undergoes HPLC purity, heavy metal, and microbial testing under an ISO9001 quality system before being packed in moisture-barrier aluminum bags.
Quality Specifications
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white powder | White to off-white powder |
| Particle size (through 80 mesh) | ≥95% | 98% |
| Assay (HPLC, dry basis) | ≥98.0% | 98.6% |
| Single maximum related substance | ≤0.5% | 0.2% |
| Loss on drying | ≤1.0% | 0.4% |
| Residue on ignition | ≤0.5% | 0.15% |
| Lead (Pb) | ≤2 mg/kg | <1 mg/kg |
| Mercury (Hg) | ≤0.1 mg/kg | <0.05 mg/kg |
| Cadmium (Cd) | ≤1 mg/kg | <0.5 mg/kg |
| Arsenic (As) | ≤1 mg/kg | <0.5 mg/kg |
| Total plate count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & mold | ≤100 CFU/g | <10 CFU/g |
| E. coli | Negative/25g | Negative |
| Salmonella | Negative/25g | Negative |
Purity & Assay Method
Purity is determined by reverse-phase HPLC with UV detection, quantifying the nicotinamide riboside cation content against a certified reference standard on a dry-weight basis. Buyers should confirm the specific column, mobile phase, and detection wavelength used, request a batch-specific certificate of analysis, and, where regulatory submission is involved, verify method validation data and reference standard traceability with PathGene before finalizing formulation specifications.
Solubility & Formulation
NRHM is soluble in water, making it suitable for both solid-dose and liquid/effervescent delivery formats. Its principal formulation advantage, however, is the markedly lower hygroscopicity of the malate salt versus chloride-form NR, which reduces caking and potency loss during tablet compression, hard-capsule filling, and powder blending, particularly in humid or tropical distribution environments. Typical inclusion levels of 300-500 mg per unit dose are compatible with common tableting and encapsulation excipients; wet or dry granulation, direct compression, and moisture-barrier aluminum packaging (with or without nitrogen flushing) are all viable processing routes, and compatibility testing with the specific excipient system is recommended before scale-up.
Available Product Forms
Bulk NRHM Powder
High-purity raw powder for supplement factories, research organizations, ingredient distributors, and contract manufacturers.
NRHM Capsules
Custom capsule strength, shell material, bottle count, excipients, and label design for private-label brands.
NRHM Tablets
Tablet formulation, granulation, compression, coating, bottle packaging, and custom labeling support.
NRHM Powder Blends
NRHM can be blended with complementary actives (antioxidants, other longevity ingredients, vitamins, minerals) per customer formula.
What purity level does NRHM come in, and can I get a certificate of analysis?+
PathGene supplies NRHM at ≥98.0% purity, confirmed by HPLC against a certified reference standard. A batch-specific certificate of analysis (COA) covering assay, moisture, heavy metals, and microbial testing is provided with every shipment.
How is NRHM manufactured, and is it a synthetic or natural-derived ingredient?+
NRHM is produced via a biosynthetic/enzymatic platform in which nicotinamide and a ribose-derived glycosyl donor are enzymatically coupled to form nicotinamide riboside, which is then converted to the malate salt through PathGene's patented electrodialysis desalination process. While nicotinamide riboside itself occurs naturally in trace amounts in foods such as milk, the commercial NRHM salt is manufactured, not extracted from a natural source.
Is NRHM water-soluble, and what formulation formats does it support?+
Yes, NRHM is soluble in water and can be used in tablets, hard capsules, powder blends, and liquid or effervescent formats. Its low hygroscopicity compared to chloride-form NR is especially advantageous for compressed tablets and capsules stored without nitrogen flushing.
Can I request a sample before placing a bulk order?+
Yes, small samples are available on request for evaluation and formulation trials. Please contact our sales team with your intended application and required quantity.
Do you support third-party testing or independent verification of specs?+
Yes, in addition to our in-house COA, buyers are welcome to submit samples to an independent third-party laboratory for verification of purity, heavy metals, and microbial limits before committing to a bulk purchase.
Do you offer OEM or private-label services for NRHM-based products?+
Yes, PathGene supports OEM and private-label formulation services, including custom blends, dosage strengths, and finished tablet or capsule development built around NRHM as the NAD+ precursor ingredient.
What packaging options are available for bulk NRHM?+
NRHM is typically packed in moisture-barrier aluminum foil bags to protect the low-hygroscopicity powder during storage and shipping; custom packaging sizes and nitrogen-flushed options can be arranged on request.
What is the minimum order quantity (MOQ), and how do I get a quotation?+
MOQ varies by packaging format and intended application; please contact our sales team with your target volume, purity requirement, and destination market to receive a tailored quotation and lead-time estimate.
Why Choose PathGene
- Direct China manufacturer supply — factory pricing, no middleman
- Batch-specific COA & full traceability on every shipment
- In-house R&D + synthetic biology / enzymatic production platform
- Free sample for qualified B2B buyers before commercial order
- Flexible MOQ — from lab-scale trial to ton-scale commercial supply
- One-stop OEM/private-label support for finished dosage forms
- Worldwide shipping by courier, air freight, and sea freight
OEM & Private-Label Services
- ·Custom capsule manufacturing
- ·Custom tablet manufacturing
- ·Powder blending & custom formulation
- ·Private-label bottles, pouches & labels
- ·Small trial orders
- ·Bulk commercial production
- ·Export documentation
- ·Third-party laboratory testing
Documents Available
- ·Certificate of Analysis (COA)
- ·Product specification sheet
- ·Material Safety Data Sheet (MSDS)
- ·Manufacturing flow chart
- ·HPLC test report
- ·Heavy-metal test report
- ·Microbiological test report
- ·Non-GMO / allergen statement
- ·Country-of-origin documentation
- ·Packing list & commercial invoice
Certificate availability should be confirmed with our sales team before ordering.
Sample Certificate of Analysis
PathGene Biotech Co., Ltd.
南京派琪生物科技有限公司
CERTIFICATE OF ANALYSIS
Layout example — not an issued batch record
Product Name
NRHM
CAS No.
2415659-01-5
Batch No.
PG-SAMPLE-000000
Packaging
Issued upon order confirmation
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white powder | White to off-white powder |
| Particle size (through 80 mesh) | ≥95% | 98% |
| Assay (HPLC, dry basis) | ≥98.0% | 98.6% |
| Single maximum related substance | ≤0.5% | 0.2% |
| Loss on drying | ≤1.0% | 0.4% |
| Residue on ignition | ≤0.5% | 0.15% |
| Lead (Pb) | ≤2 mg/kg | <1 mg/kg |
| Mercury (Hg) | ≤0.1 mg/kg | <0.05 mg/kg |
| Cadmium (Cd) | ≤1 mg/kg | <0.5 mg/kg |
| Arsenic (As) | ≤1 mg/kg | <0.5 mg/kg |
| Total plate count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & mold | ≤100 CFU/g | <10 CFU/g |
| E. coli | Negative/25g | Negative |
| Salmonella | Negative/25g | Negative |
Conclusion: Conforms to internal quality specifications
The COA issued with your order will carry the actual batch number, manufacture/test dates, and QC signature.
Related Products
Interested in NRHM?
Our R&D team will respond to your inquiry or sample request within 24 hours.
