NRHM
CAS 2415659-01-5
Purity≥98.0%
Bulk NRHM powder for capsule, tablet and powder-blend development
PathGene supplies bulk NRHM powder (CAS 2415659-01-5) with a specified purity of ≥98.0% for capsule, tablet and powder-blend development. Request a batch COA, sample, packaging details and lead time. NAD+ ingredients
Confirm hydrogen-malate salt form, water content and solid-state stability.
Key Specifications
| Product Positioning | Bulk NRHM powder for capsule, tablet and powder-blend development |
| Application Scenarios | hydrogen-malate salt research · solid-form screening · low-hygroscopicity dosage-form work |
| CAS Number | 2415659-01-5 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₅H₂₀N₂O₁₀ |
| Molecular Weight | 388.33 g/mol |
| Appearance | White to off-white powder |
| Solubility | Soluble in water |
| Storage | 2–8°C, protect from light and moisture |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Nicotinamide Riboside Hydrogen Malate powder (NRHM, CAS 2415659-01-5) is a crystalline salt of nicotinamide riboside (NR), a vitamin B3-related pyridine nucleoside. The NRHM salt has molecular formula C15H20N2O10 and molecular weight 388.33 g/mol, pairing NR with hydrogen L-malate rather than chloride. Commercial bulk NRHM powder is produced through a controlled biosynthetic/enzymatic route, followed by salt formation, crystallization and drying to yield a white to off-white powder specified at ≥98.0% purity.
≥98% Verified Purity
Each batch is confirmed at ≥98.0% purity by HPLC against a validated reference standard, with a full certificate of analysis provided for every shipment.
Controlled Biosynthetic Production
Produced via an enzymatic coupling step and a patented electrodialysis desalination process, giving tight control over raw-material quality and final salt purity, batch after batch.
Low-Hygroscopicity Powder Form
Supplied as a free-flowing white to off-white powder with markedly lower hygroscopicity than chloride-form NR, simplifying storage, handling, and tableting.
Full Contaminant Screening
Every lot is screened for heavy metals (Pb, Hg, Cd, As) and microbial limits (total plate count, yeast & mold, E. coli, Salmonella) to meet food- and supplement-grade requirements.
Flexible Bulk & OEM Supply
Available in bulk quantities with customizable packaging, moisture-barrier aluminum bags, and OEM/private-label support for tablet, capsule, and powder-blend applications.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGNRM-260412
Test date
2026-04-15
Specification
Q/PGNRM-2025
Pack size
25 kg/carton
Storage
2–8°C, protect from light and moisture
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white crystalline powder | Off-White crystalline Powder |
| Identification | HPLC main peak retention time consistent with reference | Complies |
| Purity | ≥98.0% | 99.9% |
| Assay (dry basis) | ≥98.0% | 99.5% |
| Water | ≤2% | 1.02% |
| Organic solvents | ≤0.1% | Complies |
| Lead (Pb) | ≤1.0 ppm | Complies |
| Mercury (Hg) | ≤1.0 ppm | Complies |
| Cadmium (Cd) | ≤1.0 ppm | Complies |
| Arsenic (As) | ≤1.0 ppm | Complies |
| Total microbial count | ≤500 CFU/g | <10 |
| Coliform | ≤0.92 MPN/g | Complies |
| Mold and yeast | ≤50 CFU/g | Complies |
| Staphylococcus aureus | 0/25 g | Complies |
| Salmonella | 0/25 g | Complies |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
NRHM provides the NR moiety, while TMG can participate in homocysteine remethylation through the BHMT pathway. The pair can be evaluated as an NAD⁺-precursor and methyl-donor balance research direction.
Evidence: Mechanistic rationale; no direct clinical trial establishing finished-product synergy for NRHM+TMG was identified. Dose, stability and regulatory suitability require validation.Source
NRHM focuses on NAD⁺ precursor supply, while PQQ is studied in redox signaling and mitochondrial biology. The pair can be screened as an energy-metabolism formulation concept.
Evidence: Evidence is mainly mechanistic and preclinical, not a guarantee of clinical synergy. Compatibility, photostability and finished-dosage-form testing are required.Source
Literature-Supported Research Directions
Literature has described the preparation, crystal-form development and scale-up of nicotinamide riboside hydrogen malate, indicating that the counter-ion and crystal form can affect solid-state properties and handling. This supports salt-form and process research, not a batch-specific stability or human-efficacy claim.
Citation: Schabert et al., Molecules (2021): crystalline NR hydrogen-malate salts and manufacturing research.View source
The NR moiety in NRHM has been studied in humans through changes in whole-blood and skeletal-muscle NAD⁺ metabolites. Bioavailability, dose response and finished-product outcomes for NRHM versus chloride-form NR require salt- and formulation-specific validation.
Citation: Conze et al. (2019) and Elhassan et al. (2017): human NR safety and skeletal-muscle NAD⁺ metabolome studies.View source
NRHM can be evaluated in moisture-sensitive tablets, hard capsules and powder blends. Its formulation value is related primarily to salt-form and solid-state handling; compression, excipient compatibility, long-term stability and moisture-barrier performance require product-specific testing.
Citation: Schabert et al., Molecules (2021); formulation performance requires batch-specific testing.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
1 kg
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Insulated Box + Carton
For products requiring temperature-controlled transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Biosynthetic Precursor Preparation
Ribose-derived glycosyl donor and nicotinamide precursor are prepared, with ribose typically sourced from microbial fermentation or enzymatic glucose conversion.
Enzymatic Glycosylation
A biocatalyst (a nucleoside phosphorylase/ribosyltransferase-type enzyme) couples nicotinamide with the activated ribose donor to construct the nicotinamide riboside (NR) nucleoside, initially isolated as an NR salt intermediate.
Reaction Workup and Primary Purification
The crude reaction mixture is clarified, decolorized with activated carbon, and concentrated to isolate the NR intermediate before salt conversion.
Electrodialysis Ion-Exchange (Desalination)
A patented membrane-based electrodialysis process removes the original counter-ion and exchanges it for hydrogen malate derived from L-malic acid, converting the intermediate into NRHM in solution.
Controlled Crystallization
Cooling or anti-solvent crystallization is used to precipitate NRHM in a defined crystal form associated with reduced moisture uptake.
Isolation and Drying
Crystals are separated by filtration or centrifugation and dried under controlled temperature and humidity to protect the moisture-sensitive product.
Milling and Particle Size Control
The dried material is milled and sieved to achieve a uniform particle size suited to direct compression, capsule filling, and powder blending.
Quality Control and Packaging
Each batch undergoes HPLC purity, heavy metal, and microbial testing under an ISO9001 quality system before being packed in moisture-barrier aluminum bags.
Purity is determined by reverse-phase HPLC with UV detection, quantifying the nicotinamide riboside cation content against a certified reference standard on a dry-weight basis. Buyers should confirm the specific column, mobile phase, and detection wavelength used, request a batch-specific certificate of analysis, and, where regulatory submission is involved, verify method validation data and reference standard traceability with PathGene before finalizing formulation specifications.
NRHM is soluble in water, making it suitable for both solid-dose and liquid/effervescent delivery formats. Its principal formulation advantage, however, is the markedly lower hygroscopicity of the malate salt versus chloride-form NR, which reduces caking and potency loss during tablet compression, hard-capsule filling, and powder blending, particularly in humid or tropical distribution environments. Typical inclusion levels of 300-500 mg per unit dose are compatible with common tableting and encapsulation excipients; wet or dry granulation, direct compression, and moisture-barrier aluminum packaging (with or without nitrogen flushing) are all viable processing routes, and compatibility testing with the specific excipient system is recommended before scale-up.
PathGene supplies NRHM at ≥98.0% purity, confirmed by HPLC against a certified reference standard. A batch-specific certificate of analysis (COA) covering assay, moisture, heavy metals, and microbial testing is provided with every shipment.
NRHM is produced via a biosynthetic/enzymatic platform in which nicotinamide and a ribose-derived glycosyl donor are enzymatically coupled to form nicotinamide riboside, which is then converted to the malate salt through PathGene's patented electrodialysis desalination process. While nicotinamide riboside itself occurs naturally in trace amounts in foods such as milk, the commercial NRHM salt is manufactured, not extracted from a natural source.
Yes, NRHM is soluble in water and can be used in tablets, hard capsules, powder blends, and liquid or effervescent formats. Its low hygroscopicity compared to chloride-form NR is especially advantageous for compressed tablets and capsules stored without nitrogen flushing.
Yes, small samples are available on request for evaluation and formulation trials. Please contact our sales team with your intended application and required quantity.
Yes, in addition to our in-house COA, buyers are welcome to submit samples to an independent third-party laboratory for verification of purity, heavy metals, and microbial limits before committing to a bulk purchase.
Yes, PathGene supports OEM and private-label formulation services, including custom blends, dosage strengths, and finished tablet or capsule development built around NRHM as the NAD+ precursor ingredient.
NRHM is typically packed in moisture-barrier aluminum foil bags to protect the low-hygroscopicity powder during storage and shipping; custom packaging sizes and nitrogen-flushed options can be arranged on request.
MOQ varies by packaging format and intended application; please contact our sales team with your target volume, purity requirement, and destination market to receive a tailored quotation and lead-time estimate.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
A practical NR gummy decision guide: compare NRC and NRHM by raw-material taste, NR-equivalent dose, humidity control, packaging, and stability testing.
Selling NMN, NR or NAD+ in Australia? Compare TGA listing conditions, NRC food-use permissions and the questions to resolve before sourcing ingredients.
A practical comparison of NR Chloride and NR Hydrogen Malate for capsules and tablets, covering salt form, NR-equivalent dosing, moisture, flow, compression, and stability.
Related Products
NMN Powder (β-Nicotinamide Mononucleotide)
NAD+ Powder (β-Nicotinamide Adenine Dinucleotide)
Nicotinamide Riboside Chloride Powder (NR/NRC)
NMNH Powder (Reduced Nicotinamide Mononucleotide)
Interested in NRHM?
Our R&D team will respond to your inquiry or sample request within 24 hours.
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Alex Huang · Mon–Fri 9am–6pm CST
