NRC
Nicotinamide Riboside Chloride
Key Specifications
| CAS Number | 23111-00-4 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₁H₁₅ClN₂O₅ |
| Molecular Weight | 290.70 g/mol |
| Appearance | White crystalline powder |
| Solubility | Freely soluble in water |
| Storage | 2–8°C, protect from light |
| Shelf Life | 24 months |
CAS 23111-00-4
What Is NRC?
Nicotinamide Riboside Chloride (NRC, CAS 23111-00-4) is the crystalline chloride salt of nicotinamide riboside, a pyridine-nucleoside precursor in the vitamin B3 family. Its molecular formula is C11H15ClN2O5, with a molecular weight of 290.70 g/mol. NR occurs naturally only in trace amounts, such as in milk, and natural extraction cannot supply the quantities needed for supplement-grade ingredients, so commercial bulk material is manufactured synthetically. Industrial production typically starts from D-ribose, which is protected and stereoselectively coupled with a nicotinamide/nicotinate donor under Vorbruggen-type glycosylation conditions to form the beta-configured nucleoside. This intermediate is then deprotected, converted to the chloride salt with hydrochloric acid, and recrystallized to yield a stable, high-purity white crystalline powder suitable for supplement and formulation use.
Other Names
Key Features
High-Purity, Batch-Verified Assay
Each batch is assayed at ≥98.0% purity by HPLC, with certificates of analysis available on request to confirm consistency before you commit to volume.
Controlled Chemical Synthesis
Produced via a multi-step chemical synthesis and recrystallization process with tightly monitored temperature, pH, and reaction time to minimize by-products and ensure batch-to-batch stability.
Stable White Crystalline Form
Supplied as a free-flowing white crystalline powder that is freely water-soluble, easy to handle, and stable under recommended storage conditions.
Rigorous Contaminant Testing
Heavy metals (Pb, Hg, Cd, As) are controlled to ≤1 ppm, with routine microbial testing to help ensure the material meets supplement-grade safety expectations.
Flexible Bulk & OEM Supply
Available in bulk quantities suitable for capsules, tablets, effervescent tablets, and powder blends, with OEM/private-label and custom packaging options for brand partners.
| Molecular Formula | C₁₁H₁₅ClN₂O₅ |
| Molecular Weight | 290.70 g/mol |
| Appearance | White crystalline powder |
| Solubility | Freely soluble in water |
| Storage Condition | 2–8°C, protect from light |
| Shelf Life | 24 months |
| Grade 1 | Pharmaceutical Grade · ≥98.0% · COA |
End-Product Applications
Overview
NRC (Nicotinamide Riboside Chloride) boosts NAD⁺ via the salvage pathway with high oral bioavailability. PathGene produces NRC by chemical synthesis + recrystallization purification (heavy metals ≤1 ppm, stable white crystals).
Mechanism & Benefits
NR → NMN → NAD⁺; activates sirtuins and PARP repair
Typical Dosage
250–500 mg/serving
Compatible Formulations
capsule, tablet, effervescent tablet, powder blend
Target Market
sports nutrition brands, cognitive health supplements, healthy aging product lines positioning around energy and mental clarity
Packaging Options
1 kg 5 kg 25 kg
Lead Time
5–7 business days
Minimum Order
1 kg
Custom Packaging
Custom packaging (foil bags, HDPE drums), GMP labeling, and export documentation are available. Contact us for specifics.Certifications
ISO
ISO
ISO9001
ISO 9001
Manufacturing Process
Raw Material Preparation
D-ribose, a widely available and inexpensive sugar, is selected as the starting material and its hydroxyl groups are chemically protected to control the subsequent reaction.
Glycosylation / Nicotinamide Coupling
The protected ribose intermediate is coupled with a nicotinamide (or nicotinate) donor under Vorbruggen-type glycosylation conditions to form the pyridine-nucleoside backbone.
Stereoselective Beta-Anomer Isolation
Reaction conditions are tuned to favor formation of the biologically relevant beta-anomer, which is separated from minor alpha-anomer by-products.
Deprotection
Protecting groups on the ribose hydroxyls are removed to reveal the free nicotinamide riboside base.
Salt Formation with Hydrochloric Acid
The nicotinamide riboside cation is combined with hydrochloric acid under controlled conditions to form the more stable and shelf-friendly chloride salt.
Recrystallization & Purification
The crude chloride salt is recrystallized from a suitable solvent system to remove residual reagents, by-products, and trace metals, raising purity to specification.
Drying and Milling
Purified crystals are dried under controlled temperature and humidity, then milled to achieve a uniform, free-flowing white powder.
Quality Control & Packaging
Each batch undergoes HPLC assay, heavy metal, and microbial testing before being packaged under moisture-protective conditions for shipment.
Quality Specifications
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White crystalline powder | White crystalline powder, conforms |
| Odor | Odorless | Odorless, conforms |
| Assay (HPLC) | ≥98.0% | 98.6% |
| Loss on Drying | ≤1.0% | 0.4% |
| pH (1% aqueous solution) | 3.0–5.0 | 4.1 |
| Lead (Pb) | ≤1 ppm | <1 ppm |
| Mercury (Hg) | ≤0.5 ppm | <0.1 ppm |
| Cadmium (Cd) | ≤1 ppm | <0.5 ppm |
| Arsenic (As) | ≤1 ppm | <0.5 ppm |
| Particle Size | ≥95% through 80 mesh | 97% through 80 mesh |
| Total Plate Count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mold | ≤100 CFU/g | <10 CFU/g |
| E. coli | Negative/25 g | Negative |
| Salmonella | Negative/25 g | Negative |
Purity & Assay Method
Purity is determined by reversed-phase HPLC with UV detection against a qualified nicotinamide riboside chloride reference standard, which separates the target compound from synthesis-related impurities and anomeric by-products. Buyers should confirm the specific HPLC method and column used, the reference standard's certification, water content (Karl Fischer), and chloride counter-ion content, since these factors affect the true net assay and shelf-life performance of the material.
Solubility & Formulation
NRC is freely soluble in water, which makes it well suited for aqueous-based delivery formats such as effervescent tablets, drink powders, and liquid or gel formulations, in addition to standard capsules and compressed tablets. Because the crystalline chloride salt can be hygroscopic, formulators should use desiccant packaging and low-humidity processing conditions to prevent caking or moisture uptake, and should confirm compatibility with co-formulated actives (such as acidic or alkaline excipients) before finalizing a formula.
Available Product Forms
Bulk NRC Powder
High-purity raw powder for supplement factories, research organizations, ingredient distributors, and contract manufacturers.
NRC Capsules
Custom capsule strength, shell material, bottle count, excipients, and label design for private-label brands.
NRC Tablets
Tablet formulation, granulation, compression, coating, bottle packaging, and custom labeling support.
NRC Powder Blends
NRC can be blended with complementary actives (antioxidants, other longevity ingredients, vitamins, minerals) per customer formula.
How can I confirm the purity and specifications before ordering?+
We provide a certificate of analysis (COA) for every batch, showing HPLC assay, appearance, loss on drying, heavy metals, and microbial results, so you can verify specifications before placing an order.
How is this ingredient produced, and is it synthetic or naturally extracted?+
NRC is produced through a controlled multi-step chemical synthesis starting from D-ribose, followed by coupling, deprotection, salt formation, and recrystallization. Natural sources contain only trace amounts insufficient for commercial supply, so bulk material is manufactured synthetically to ensure purity and consistency.
Is nicotinamide riboside chloride soluble in water, and what formulations does it suit?+
Yes, NRC is freely soluble in water, making it suitable for capsules, tablets, effervescent tablets, and powder blends. Its aqueous solubility also allows use in drink mixes and liquid formulations, subject to compatibility testing with other ingredients.
Can we request a sample before placing a bulk order?+
Yes, samples are available for qualification and formulation testing prior to bulk purchase. Please contact our team to arrange sample size, cost, and shipping details.
Do you support third-party testing of the material?+
Yes, buyers are welcome to send samples to an independent third-party laboratory of their choice for verification of purity, heavy metals, and microbial specifications alongside our own COA.
Do you offer OEM or private-label services?+
Yes, we support OEM and private-label programs, including custom formulation ratios, capsule/tablet finishing, and branded packaging, tailored to sports nutrition, cognitive health, and healthy-aging product lines.
What packaging options are available for shipment?+
Standard bulk packaging is typically in moisture-protective, heat-sealed inner bags placed in fiber drums or cartons, sized according to order volume; custom packaging sizes and labeling can be arranged for OEM clients.
What is the minimum order quantity (MOQ) and how do I get a quote?+
MOQ varies depending on order form (raw material vs. finished dosage) and current production scheduling. Please contact our sales team with your target quantity and application to receive a formal quotation.
Why Choose PathGene
- Direct China manufacturer supply — factory pricing, no middleman
- Batch-specific COA & full traceability on every shipment
- In-house R&D + synthetic biology / enzymatic production platform
- Free sample for qualified B2B buyers before commercial order
- Flexible MOQ — from lab-scale trial to ton-scale commercial supply
- One-stop OEM/private-label support for finished dosage forms
- Worldwide shipping by courier, air freight, and sea freight
OEM & Private-Label Services
- ·Custom capsule manufacturing
- ·Custom tablet manufacturing
- ·Powder blending & custom formulation
- ·Private-label bottles, pouches & labels
- ·Small trial orders
- ·Bulk commercial production
- ·Export documentation
- ·Third-party laboratory testing
Documents Available
- ·Certificate of Analysis (COA)
- ·Product specification sheet
- ·Material Safety Data Sheet (MSDS)
- ·Manufacturing flow chart
- ·HPLC test report
- ·Heavy-metal test report
- ·Microbiological test report
- ·Non-GMO / allergen statement
- ·Country-of-origin documentation
- ·Packing list & commercial invoice
Certificate availability should be confirmed with our sales team before ordering.
Sample Certificate of Analysis
PathGene Biotech Co., Ltd.
南京派琪生物科技有限公司
CERTIFICATE OF ANALYSIS
Layout example — not an issued batch record
Product Name
NRC
CAS No.
23111-00-4
Batch No.
PG-SAMPLE-000000
Packaging
Issued upon order confirmation
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White crystalline powder | White crystalline powder, conforms |
| Odor | Odorless | Odorless, conforms |
| Assay (HPLC) | ≥98.0% | 98.6% |
| Loss on Drying | ≤1.0% | 0.4% |
| pH (1% aqueous solution) | 3.0–5.0 | 4.1 |
| Lead (Pb) | ≤1 ppm | <1 ppm |
| Mercury (Hg) | ≤0.5 ppm | <0.1 ppm |
| Cadmium (Cd) | ≤1 ppm | <0.5 ppm |
| Arsenic (As) | ≤1 ppm | <0.5 ppm |
| Particle Size | ≥95% through 80 mesh | 97% through 80 mesh |
| Total Plate Count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mold | ≤100 CFU/g | <10 CFU/g |
| E. coli | Negative/25 g | Negative |
| Salmonella | Negative/25 g | Negative |
Conclusion: Conforms to internal quality specifications
The COA issued with your order will carry the actual batch number, manufacture/test dates, and QC signature.
Related Products
NRHM
Nicotinamide Riboside Hydrogen Malate
Interested in NRC?
Our R&D team will respond to your inquiry or sample request within 24 hours.
