NRC
CAS 23111-00-4
Purity≥98.0%
Nicotinamide riboside chloride for NAD+ precursor formulations
Nicotinamide Riboside Chloride Powder (CAS 23111-00-4), specification ≥98.0%. The chloride salt of nicotinamide riboside; hydrogen malate and tartrate are listed as separate products. Batch COA and evaluation samples are available. MOQ: 1 kg. NAD+ ingredients
Quote / sample & delivery
Key Specifications
| Product Positioning | Nicotinamide riboside chloride for NAD+ precursor formulations |
| Application Scenarios | NAD+ precursor formulation · nucleotide metabolism research · solid-dose screening |
| CAS Number | 23111-00-4 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₁H₁₅ClN₂O₅ |
| Molecular Weight | 290.70 g/mol |
| Appearance | White crystalline powder |
| Solubility | Freely soluble in water |
| Storage | 2–8°C, protect from light |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Nicotinamide Riboside Chloride powder (NRC, NR Chloride, CAS 23111-00-4) is the crystalline chloride salt of nicotinamide riboside, a pyridine-nucleoside precursor in the vitamin B3 family. Its molecular formula is C11H15ClN2O5, with a molecular weight of 290.70 g/mol. NR occurs naturally only in trace amounts, such as in milk, and natural extraction cannot supply the quantities needed for supplement-grade ingredients, so commercial bulk material is manufactured synthetically. Industrial production typically starts from D-ribose, which is protected and stereoselectively coupled with a nicotinamide/nicotinate donor under Vorbruggen-type glycosylation conditions to form the beta-configured nucleoside. This intermediate is then deprotected, converted to the chloride salt with hydrochloric acid, and recrystallized to yield a stable, high-purity white crystalline powder suitable for supplement and formulation use.
≥98.0% Purity Specification
The product specification is ≥98.0% purity. Review the offered lot's COA for its measured purity, assay and test methods; purity and assay are reported separately.
Controlled Chemical Synthesis
Produced via a multi-step chemical synthesis and recrystallization process with tightly monitored temperature, pH, and reaction time to minimize by-products and ensure batch-to-batch stability.
Stable White Crystalline Form
Supplied as a free-flowing white crystalline powder that is freely water-soluble, easy to handle, and stable under recommended storage conditions.
Rigorous Contaminant Testing
Heavy metals (Pb, Hg, Cd, As) are controlled to ≤1 ppm, with routine microbial testing to help ensure the material meets supplement-grade safety expectations.
Flexible Bulk & OEM Supply
Available in bulk quantities suitable for capsules, tablets, effervescent tablets, and powder blends, with OEM/private-label and custom packaging options for brand partners.
Test items, specifications and results for the listed batch are shown here. View or request a COA in the quality documents section.
Batch No.
PGNRC-260621
Test date
2026-06-22
Specification
In-house
Pack size
25 kg/carton
Storage
2–8°C, protect from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white powder | Off-White Powder |
| Identification | HPLC main peak retention time consistent with reference | Complies |
| Purity | ≥98.0% | 99.70% |
| Assay | ≥98.0% | 99.3% |
| Water | ≤2% | 0.4% |
| Organic solvents | ≤0.1% | 0.05% |
| Lead (Pb) | ≤0.1 ppm | Complies |
| Mercury (Hg) | ≤0.1 ppm | Complies |
| Cadmium (Cd) | ≤0.2 ppm | Complies |
| Arsenic (As) | ≤0.1 ppm | Complies |
| Total microbial count | ≤500 CFU/g | Complies |
| Coliform | ≤0.92 MPN/g | Complies |
| Mold and yeast | ≤50 CFU/g | Complies |
| Staphylococcus aureus | 0/25 g | Complies |
| Salmonella | 0/25 g | Complies |
View an available COA in the quality documents section. Check the document for its product form and batch; request a signed COA for your purchasing or shipment batch separately.
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
Chemically synthesized nicotinamide riboside chloride powder · CAS 23111-00-4. Crystalline chloride salt, specification ≥98.0%; start development with dry capsules, tablets or sachets.
99.70%
Lot purity
99.3%
Lot assay
0.4%
Water
PGNRC-260621 · Reported lot results; confirm assay basis against the test method
Pilot compositions, loading examples and checks follow. Evaluate dry processing separately from aqueous reconstitution; solubility alone cannot validate every dosage form.
Anhydrous NRC has a molar mass of 290.70 g/mol; the NR cation is about 255.25 g/mol. The NR moiety represents about 87.81% of ideal pure salt mass.
100 mg NR⁺ × 290.70 / 255.25 ≈ 113.89 mg NRC
Stoichiometric example only, before lot-assay correction; not an intake recommendation. Confirm whether a study reports salt mass or moiety mass before converting; do not correct for chloride twice.
Campbell et al. (2019) characterized NRCl and its degradation, reporting aqueous hydrolysis to nicotinamide and sugar. Formulation screening should track assay and degradants alongside clarity.
The published experiments are not shelf-life studies of PathGene material; test the actual pH, concentration, temperature and packaging.
Campbell et al., 2019 · DOI 10.29219/fnr.v63.3419 ↗Explore NR chloride combinations through TMG/PQQ mechanisms and published NR/pterostilbene and multi-component human studies. Each card separates component roles, study findings and formulation work, without attributing blend results to NR alone.
NRC supplies the NR moiety; TMG is a methyl donor involved in homocysteine remethylation to methionine through BHMT. This concept brings NAD⁺ precursor supply and one-carbon metabolism into the same formulation framework.
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Combination rationale: NRC supplies the NR moiety; TMG is a methyl donor involved in homocysteine remethylation to methionine through BHMT. This concept brings NAD⁺ precursor supply and one-carbon metabolism into the same formulation framework.
Published evidence: Ueland et al. (2005) reviewed betaine's methyl-donor role and relationships with homocysteine and folate status. This informs TMG selection as a combination candidate; the paper addresses betaine metabolism, not an NRC + TMG intervention.
Development insights: A development concept for capsules, tablets or sachets. Set NRC and TMG targets separately, screen carriers against particle size and bulk density, and mix progressively. Track both assays, moisture, caking and uniformity; a human-study design may include one-carbon metabolism markers such as homocysteine.
Evidence scope: A mechanistic combination concept; TMG is not established as mandatory for all NR users, and this review does not establish a blend ratio.
Ueland et al., 2005 · PMID 16197300 ↗NRC focuses on NAD⁺ precursor supply, while PQQ research includes redox signalling and mitochondrial biogenesis. The pair offers different mechanistic targets for cellular-energy formulation research.
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Combination rationale: NRC focuses on NAD⁺ precursor supply, while PQQ research includes redox signalling and mitochondrial biogenesis. The pair offers different mechanistic targets for cellular-energy formulation research.
Published evidence: Saihara et al. (2017) investigated PQQ-driven mitochondrial biogenesis through SIRT1/PGC-1α signalling. This supplies a cellular rationale on the PQQ side for developing an NRC/PQQ hypothesis and selecting evaluation endpoints.
Development insights: Start with capsule, tablet or powder-blend development. At low PQQ loading, preblend with part of the carrier before adding to the NRC bulk blend and assay each component. For reconstitution, assess pH, colour, clarity and assay after holding. Research endpoints can include NAD⁺, mitochondrial and redox markers.
Evidence scope: This source studies PQQ mechanisms; it does not directly establish human synergy for NRC + PQQ.
Saihara et al., 2017 · PMID 29185343 ↗PQQ disodium ingredient and COA →Combining NR with the polyphenol pterostilbene is an NR formulation route already studied in humans, providing a concrete literature example for NAD⁺-focused development.
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Combination rationale: Combining NR with the polyphenol pterostilbene is an NR formulation route already studied in humans, providing a concrete literature example for NAD⁺-focused development.
Published evidence: Dellinger et al. (2017) conducted an eight-week randomized, double-blind, placebo-controlled trial in 120 healthy adults aged 60–80. Study capsules contained 125 mg NR and 25 mg pterostilbene; whole-blood NAD⁺ increased about 40% and 90% from baseline at week four in the two dose groups. These are the published formulation and observations.
Development insights: The capsule format and excipient system—microcrystalline cellulose, silicon dioxide, magnesium stearate and gelatin shell—provide practical references. For NRC selection, confirm the study dose basis and calculate loading against the lot assay, then examine both active assays, blend uniformity and packaged stability. A human-study design should include NAD⁺ and lipid markers.
Evidence scope: The trial tested a specific NR product blend, not a finished product using PathGene NRC. It lacked an NR-only arm to isolate synergy. Review lipid findings alongside NAD⁺ changes; study doses are not intake recommendations for this ingredient.
Dellinger et al., 2017 · DOI 10.1038/s41514-017-0016-9 ↗Pterostilbene powder ingredient →Published Combined Metabolic Activators (CMA) formulations combine NR as an NAD⁺ precursor, NAC and serine as glutathione-precursor-related components, and L-carnitine tartrate for multi-pathway fatty-acid metabolism and redox research.
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Combination rationale: Published Combined Metabolic Activators (CMA) formulations combine NR as an NAD⁺ precursor, NAC and serine as glutathione-precursor-related components, and L-carnitine tartrate for multi-pathway fatty-acid metabolism and redox research.
Published evidence: A phase-II controlled study published in 2021 randomized 31 participants with NAFLD; 30 completed 70 days. Each original serving contained 1 g NR, 2.55 g NAC, 12.35 g L-serine and 3.73 g L-carnitine tartrate. Liver fat, clinical markers and metabolomic changes were assessed. The published composition illustrates formulation volume and evaluation design.
Development insights: The original gram-scale mixture has a fill burden well beyond a typical single capsule, making powder/sachet capacity a useful development topic. Selecting NRC requires checking the reporting basis of the study dose and assessment of taste, reconstitution, sachet uniformity, and dry-blend and aqueous stability.
Evidence scope: A research blend studied in a specific patient population, not a general-consumer recipe or NRC treatment claim. Four-component findings cannot be attributed to NR alone.
Combined metabolic activators study, 2021 · PMCID PMC8724764 ↗The NR series uses chemical synthesis. Check CAS, counter-ion, assay basis and stability data separately for chloride, hydrogen malate and tartrate.
Literature-Supported Research Directions
A randomized controlled trial found that nicotinamide riboside chloride increased whole-blood NAD⁺ and related metabolites in healthy overweight adults and was generally well tolerated within the studied dose range.
Citation: Conze et al., Scientific Reports (2019): safety and metabolism of long-term nicotinamide riboside supplementation.View source
In a randomized crossover study in older men, NR increased the skeletal-muscle NAD⁺ metabolome and altered selected transcriptomic and inflammatory signatures; mitochondrial functional outcomes require further study.
Citation: Elhassan et al. Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures. Cell reports (2019). PMID: 31412242.View source
Human studies of NR on insulin sensitivity, lipid metabolism and mitochondrial function are not fully consistent, so this area is best presented as an NAD⁺ metabolism and formulation research direction rather than a definitive efficacy claim.
Citation: Dollerup et al. (2018) and Remie et al. (2020): human metabolic studies of NR.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
1 kg
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Insulated Box + Carton
For products requiring temperature-controlled transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Raw Material Preparation
D-ribose, a widely available and inexpensive sugar, is selected as the starting material and its hydroxyl groups are chemically protected to control the subsequent reaction.
Glycosylation / Nicotinamide Coupling
The protected ribose intermediate is coupled with a nicotinamide (or nicotinate) donor under Vorbruggen-type glycosylation conditions to form the pyridine-nucleoside backbone.
Stereoselective Beta-Anomer Isolation
Reaction conditions are tuned to favor formation of the biologically relevant beta-anomer, which is separated from minor alpha-anomer by-products.
Deprotection
Protecting groups on the ribose hydroxyls are removed to reveal the free nicotinamide riboside base.
Salt Formation with Hydrochloric Acid
The nicotinamide riboside cation is combined with hydrochloric acid under controlled conditions to form the more stable and shelf-friendly chloride salt.
Recrystallization & Purification
The crude chloride salt is recrystallized from a suitable solvent system to remove residual reagents, by-products, and trace metals, raising purity to specification.
Drying and Milling
Purified crystals are dried under controlled temperature and humidity, then milled to achieve a uniform, free-flowing white powder.
Quality Control & Packaging
Each batch undergoes HPLC assay, heavy metal, and microbial testing before being packaged under moisture-protective conditions for shipment.
Purity is determined by reversed-phase HPLC with UV detection against a qualified nicotinamide riboside chloride reference standard, which separates the target compound from synthesis-related impurities and anomeric by-products. Buyers should confirm the specific HPLC method and column used, the reference standard's certification, water content (Karl Fischer), and chloride counter-ion content, since these factors affect the true net assay and shelf-life performance of the material.
NRC is freely soluble in water, which makes it well suited for aqueous-based delivery formats such as effervescent tablets, drink powders, and liquid or gel formulations, in addition to standard capsules and compressed tablets. Because the crystalline chloride salt can be hygroscopic, formulators should use desiccant packaging and low-humidity processing conditions to prevent caking or moisture uptake, and should confirm compatibility with co-formulated actives (such as acidic or alkaline excipients) before finalizing a formula.
We provide a certificate of analysis (COA) for every batch, showing HPLC assay, appearance, loss on drying, heavy metals, and microbial results, so you can verify specifications before placing an order.
NRC is produced through a controlled multi-step chemical synthesis starting from D-ribose, followed by coupling, deprotection, salt formation, and recrystallization. Natural sources contain only trace amounts insufficient for commercial supply, so bulk material is manufactured synthetically to ensure purity and consistency.
Yes, NRC is freely soluble in water, making it suitable for capsules, tablets, effervescent tablets, and powder blends. Its aqueous solubility also allows use in drink mixes and liquid formulations, subject to compatibility testing with other ingredients.
Yes, samples are available for qualification and formulation testing prior to bulk purchase. Please contact our team to arrange sample size, cost, and shipping details.
Yes, buyers are welcome to send samples to an independent third-party laboratory of their choice for verification of purity, heavy metals, and microbial specifications alongside our own COA.
Yes, we support OEM and private-label programs, including custom formulation ratios, capsule/tablet finishing, and branded packaging, tailored to sports nutrition, cognitive health, and healthy-aging product lines.
NR chloride powder pack options are 1 kg, 5 kg, 25 kg. Special inner-packaging, labeling and transport requirements are agreed separately for the order.
The raw-material MOQ for NR chloride powder is 1 kg, with pack options of 1 kg, 5 kg, 25 kg. Finished-product OEM minimums are assessed as a separate project.
NRC is nicotinamide riboside chloride, CAS 23111-00-4: the chloride salt form of NR. Specify the salt and assay basis when ordering. NR chloride, hydrogen malate and tartrate each require their own specification and batch COA.
No. Confirm the required salt, composition and assay basis. Match stability and market documents to the exact offered material before substitution.
Water solubility and liquid stability are separate. Measure NR and nicotinamide at the intended pH, temperature, processing time and storage conditions. Dry-capsule stability or an ingredient COA does not establish shelf life after reconstitution.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Check the COA for the applicable batch
Technical Resources
Compare the three NR salt powders by exact identity, CAS, assay basis and batch evidence, with direct links to PathGene chloride, hydrogen malate and tartrate specifications.
A practical comparison of NR Chloride and NR Hydrogen Malate for capsules and tablets, covering salt form, NR-equivalent dosing, moisture, flow, compression, and stability.
A head-to-head technical comparison of NMN and NR for nutraceutical and pharmaceutical formulators — covering bioavailability, stability, purity targets, and regulatory status.
Related Products
NMN Powder (β-Nicotinamide Mononucleotide)
β-Nicotinamide Adenine Dinucleotide (NAD+) Powder
Nicotinamide Riboside Hydrogen Malate Powder
Reduced Nicotinamide Mononucleotide (NMNH) Powder
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