NRC
CAS 23111-00-4
Purity≥98.0%
Nicotinamide riboside chloride for NAD+ precursor formulations
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore NAD+ ingredients.
Confirm chloride salt form and assay calculation basis (as-is or dry/salt basis).
Key Specifications
| Product Positioning | Nicotinamide riboside chloride for NAD+ precursor formulations |
| Application Scenarios | NAD+ precursor formulation · nucleotide metabolism research · solid-dose screening |
| CAS Number | 23111-00-4 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₁H₁₅ClN₂O₅ |
| Molecular Weight | 290.70 g/mol |
| Appearance | White crystalline powder |
| Solubility | Freely soluble in water |
| Storage | 2–8°C, protect from light |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Nicotinamide Riboside Chloride powder (NRC, NR Chloride, CAS 23111-00-4) is the crystalline chloride salt of nicotinamide riboside, a pyridine-nucleoside precursor in the vitamin B3 family. Its molecular formula is C11H15ClN2O5, with a molecular weight of 290.70 g/mol. NR occurs naturally only in trace amounts, such as in milk, and natural extraction cannot supply the quantities needed for supplement-grade ingredients, so commercial bulk material is manufactured synthetically. Industrial production typically starts from D-ribose, which is protected and stereoselectively coupled with a nicotinamide/nicotinate donor under Vorbruggen-type glycosylation conditions to form the beta-configured nucleoside. This intermediate is then deprotected, converted to the chloride salt with hydrochloric acid, and recrystallized to yield a stable, high-purity white crystalline powder suitable for supplement and formulation use. For private label and OEM projects, contact PathGene about capsule or tablet development and packaging. Finished-product minimum orders and schedules are quoted separately from bulk raw material orders.
≥99% Assayed Purity
Each batch is assayed at ≥99% purity by HPLC, with certificates of analysis available on request to confirm consistency before you commit to volume.
Controlled Chemical Synthesis
Produced via a multi-step chemical synthesis and recrystallization process with tightly monitored temperature, pH, and reaction time to minimize by-products and ensure batch-to-batch stability.
Stable White Crystalline Form
Supplied as a free-flowing white crystalline powder that is freely water-soluble, easy to handle, and stable under recommended storage conditions.
Rigorous Contaminant Testing
Heavy metals (Pb, Hg, Cd, As) are controlled to ≤1 ppm, with routine microbial testing to help ensure the material meets supplement-grade safety expectations.
Flexible Bulk & OEM Supply
Available in bulk quantities suitable for capsules, tablets, effervescent tablets, and powder blends, with OEM/private-label and custom packaging options for brand partners.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGNRC-260621
Test date
2026-06-22
Specification
In-house
Pack size
25 kg/carton
Storage
2–8°C, protect from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white powder | Off-White Powder |
| Identification | HPLC main peak retention time consistent with reference | Complies |
| Purity | ≥98.0% | 99.70% |
| Assay | ≥98.0% | 99.3% |
| Water | ≤2% | 0.4% |
| Organic solvents | ≤0.1% | 0.05% |
| Lead (Pb) | ≤0.1 ppm | Complies |
| Mercury (Hg) | ≤0.1 ppm | Complies |
| Cadmium (Cd) | ≤0.2 ppm | Complies |
| Arsenic (As) | ≤0.1 ppm | Complies |
| Total microbial count | ≤500 CFU/g | Complies |
| Coliform | ≤0.92 MPN/g | Complies |
| Mold and yeast | ≤50 CFU/g | Complies |
| Staphylococcus aureus | 0/25 g | Complies |
| Salmonella | 0/25 g | Complies |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
After NR enters the NAD⁺ salvage network, nicotinamide metabolism becomes relevant; TMG can participate in homocysteine remethylation through BHMT, supporting a one-carbon-balance formulation research direction.
Evidence: This is a mechanistic formulation hypothesis; no direct clinical trial establishing finished-product synergy for NR+TMG was identified. Dose, stability and regulatory suitability require validation.Source
NR focuses on NAD⁺ precursor supply, while PQQ is studied in redox signaling and mitochondrial biogenesis. The pair can be screened as an energy-metabolism and oxidative-stress formulation concept.
Evidence: Evidence is mainly mechanistic and preclinical, not proof of human synergy. Compatibility, photostability and finished-dosage-form testing are required.Source
Literature-Supported Research Directions
A randomized controlled trial found that nicotinamide riboside chloride increased whole-blood NAD⁺ and related metabolites in healthy overweight adults and was generally well tolerated within the studied dose range.
Citation: Conze et al., Scientific Reports (2019): safety and metabolism of long-term nicotinamide riboside supplementation.View source
In a randomized crossover study in older men, NR increased the skeletal-muscle NAD⁺ metabolome and altered selected transcriptomic and inflammatory signatures; mitochondrial functional outcomes require further study.
Citation: Elhassan et al., npj Aging and Mechanisms of Disease (2017): NR and the aged human skeletal-muscle NAD⁺ metabolome.View source
Human studies of NR on insulin sensitivity, lipid metabolism and mitochondrial function are not fully consistent, so this area is best presented as an NAD⁺ metabolism and formulation research direction rather than a definitive efficacy claim.
Citation: Dollerup et al. (2018) and Remie et al. (2020): human metabolic studies of NR.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
1 kg
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Insulated Box + Carton
For products requiring temperature-controlled transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Raw Material Preparation
D-ribose, a widely available and inexpensive sugar, is selected as the starting material and its hydroxyl groups are chemically protected to control the subsequent reaction.
Glycosylation / Nicotinamide Coupling
The protected ribose intermediate is coupled with a nicotinamide (or nicotinate) donor under Vorbruggen-type glycosylation conditions to form the pyridine-nucleoside backbone.
Stereoselective Beta-Anomer Isolation
Reaction conditions are tuned to favor formation of the biologically relevant beta-anomer, which is separated from minor alpha-anomer by-products.
Deprotection
Protecting groups on the ribose hydroxyls are removed to reveal the free nicotinamide riboside base.
Salt Formation with Hydrochloric Acid
The nicotinamide riboside cation is combined with hydrochloric acid under controlled conditions to form the more stable and shelf-friendly chloride salt.
Recrystallization & Purification
The crude chloride salt is recrystallized from a suitable solvent system to remove residual reagents, by-products, and trace metals, raising purity to specification.
Drying and Milling
Purified crystals are dried under controlled temperature and humidity, then milled to achieve a uniform, free-flowing white powder.
Quality Control & Packaging
Each batch undergoes HPLC assay, heavy metal, and microbial testing before being packaged under moisture-protective conditions for shipment.
Purity is determined by reversed-phase HPLC with UV detection against a qualified nicotinamide riboside chloride reference standard, which separates the target compound from synthesis-related impurities and anomeric by-products. Buyers should confirm the specific HPLC method and column used, the reference standard's certification, water content (Karl Fischer), and chloride counter-ion content, since these factors affect the true net assay and shelf-life performance of the material.
NRC is freely soluble in water, which makes it well suited for aqueous-based delivery formats such as effervescent tablets, drink powders, and liquid or gel formulations, in addition to standard capsules and compressed tablets. Because the crystalline chloride salt can be hygroscopic, formulators should use desiccant packaging and low-humidity processing conditions to prevent caking or moisture uptake, and should confirm compatibility with co-formulated actives (such as acidic or alkaline excipients) before finalizing a formula.
We provide a certificate of analysis (COA) for every batch, showing HPLC assay, appearance, loss on drying, heavy metals, and microbial results, so you can verify specifications before placing an order.
NRC is produced through a controlled multi-step chemical synthesis starting from D-ribose, followed by coupling, deprotection, salt formation, and recrystallization. Natural sources contain only trace amounts insufficient for commercial supply, so bulk material is manufactured synthetically to ensure purity and consistency.
Yes, NRC is freely soluble in water, making it suitable for capsules, tablets, effervescent tablets, and powder blends. Its aqueous solubility also allows use in drink mixes and liquid formulations, subject to compatibility testing with other ingredients.
Yes, samples are available for qualification and formulation testing prior to bulk purchase. Please contact our team to arrange sample size, cost, and shipping details.
Yes, buyers are welcome to send samples to an independent third-party laboratory of their choice for verification of purity, heavy metals, and microbial specifications alongside our own COA.
Yes, we support OEM and private-label programs, including custom formulation ratios, capsule/tablet finishing, and branded packaging, tailored to sports nutrition, cognitive health, and healthy-aging product lines.
Standard bulk packaging is typically in moisture-protective, heat-sealed inner bags placed in fiber drums or cartons, sized according to order volume; custom packaging sizes and labeling can be arranged for OEM clients.
MOQ varies depending on order form (raw material vs. finished dosage) and current production scheduling. Please contact our sales team with your target quantity and application to receive a formal quotation.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
A practical NR gummy decision guide: compare NRC and NRHM by raw-material taste, NR-equivalent dose, humidity control, packaging, and stability testing.
Selling NMN, NR or NAD+ in Australia? Compare TGA listing conditions, NRC food-use permissions and the questions to resolve before sourcing ingredients.
A practical comparison of NR Chloride and NR Hydrogen Malate for capsules and tablets, covering salt form, NR-equivalent dosing, moisture, flow, compression, and stability.
Related Products
NMN Powder (β-Nicotinamide Mononucleotide)
NAD+ Powder (β-Nicotinamide Adenine Dinucleotide)
NRHM Powder (Nicotinamide Riboside Hydrogen Malate)
NMNH Powder (Reduced Nicotinamide Mononucleotide)
Interested in NRC?
Our R&D team will respond to your inquiry or sample request within 24 hours.
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Alex Huang · Mon–Fri 9am–6pm CST
