PSB
CAS 537-42-8
Purity≥98.0%
Stilbene polyphenol for healthy-aging formulation screening
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore nutrition & functional ingredients.
Confirm trans-isomer identity and light/oxidation controls.
Key Specifications
| Product Positioning | Stilbene polyphenol for healthy-aging formulation screening |
| Application Scenarios | stilbene polyphenol research · healthy-aging formula screening · low-dose capsule prototypes |
| CAS Number | 537-42-8 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₆H₁₆O₃ |
| Molecular Weight | 256.30 g/mol |
| Appearance | White to off-white powder |
| Solubility | Slightly soluble in water; soluble in ethanol |
| Storage | Room temperature, protect from light |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Pterostilbene is a naturally occurring dimethylated stilbenoid and a structural analog of resveratrol, identified by CAS No. 537-42-8, molecular formula C16H16O3, and molecular weight 256.30 g/mol. Chemically it is trans-3,5-dimethoxy-4'-hydroxystilbene, in which two of resveratrol's phenolic hydroxyl groups are replaced by methoxy groups, improving lipophilicity and metabolic stability relative to resveratrol. It occurs naturally in trace amounts in blueberries and other Vaccinium berries, grape leaves, and Pterocarpus marsupium heartwood. Because natural extraction yields are too low for commercial supply, bulk-scale material is typically produced industrially via a biosynthetic/enzymatic route: engineered microbial fermentation generates a resveratrol precursor, which is then enzymatically O-methylated to pterostilbene, followed by extraction, crystallization, and purification.
High-Purity Assurance
Each batch is manufactured to ≥98.0% purity and verified by HPLC before release, giving formulators a consistent, dependable active for finished-product dosing.
Controlled Bio-Enzymatic Production
Produced on PathGene's synthetic-biology platform via fermentation-derived precursor and enzymatic O-methylation, with in-process controls at every stage to ensure batch-to-batch consistency.
Fine White Powder Form
Supplied as a white to off-white powder with uniform particle size, offering good flow and blend uniformity for tableting, capsule filling, and premix applications.
Full Contaminant Screening
Every lot is screened for heavy metals (Pb, As, Hg, Cd) and microbial limits, with a COA and supporting test reports available on request.
Flexible Bulk & OEM Supply
Available in flexible order quantities from sample to bulk kilogram/ton scale, with OEM/private-label formatting, custom packaging, and documentation support.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGPT-260405
Test date
2026-04-06
Specification
Q/PGPT-2025
Pack size
25kg/
Storage
Room temperature, protect from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white crystalline powder | White to off-white powder, conforms |
| Odor | Characteristic, odorless to faint | Odorless, conforms |
| Identification (HPLC retention time) | Matches reference standard | Conforms |
| Assay (HPLC) | ≥98.0% | 98.5% |
| Melting point | 96.0-99.0 °C | 97.2 °C |
| Loss on drying | ≤0.5% | 0.2% |
| Particle size (80 mesh pass rate) | ≥95% | 98% |
| Lead (Pb) | ≤2 mg/kg | <1 mg/kg |
| Arsenic (As) | ≤1 mg/kg | <0.5 mg/kg |
| Mercury (Hg) | ≤0.1 mg/kg | <0.05 mg/kg |
| Cadmium (Cd) | ≤1 mg/kg | <0.5 mg/kg |
| Total plate count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & mold | ≤100 CFU/g | <10 CFU/g |
| Pathogens (E. coli / Salmonella) | Negative/25g | Negative |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
This pairing already exists in commercial healthy-aging supplements and has been evaluated in a randomized human trial. It can support a polyphenol-plus-NAD-precursor positioning.
Evidence: The trial evaluated the combination rather than pterostilbene alone and was company funded; do not claim proven synergy or disease prevention.Source
This combination was included as a separate arm in the human metabolic-parameter trial and can be considered for a broader polyphenol formula after compatibility and dose review.
Evidence: The study was not designed to prove formulation synergy, and pterostilbene monotherapy increased LDL; lipid-related positioning requires caution.Source
Literature-Supported Research Directions
In a randomized double-blind placebo-controlled trial of 80 adults with hypercholesterolemia, high-dose pterostilbene lowered systolic and diastolic blood pressure, while pterostilbene monotherapy increased LDL cholesterol. The mixed findings make lipid monitoring and restrained claims essential.
Citation: Riche et al., Evidence-Based Complementary and Alternative Medicine (2014), Article 459165. PMID: 25057276.View source
A two-month randomized placebo-controlled study in 60 healthy adults evaluated a Pterocarpus marsupium extract standardized to 90% pterostilbene at 200 mg/day and found no clinically relevant changes in laboratory tests, vital signs or ECG. This study used an extract, not purified pterostilbene, and does not establish long-term safety.
Citation: Bharani et al., randomized safety study (2023). PMID: 37671486.View source
A company-funded eight-week trial in 120 adults aged 60–80 tested a nicotinamide-riboside/pterostilbene combination and reported dose-dependent increases in whole-blood NAD+. Because both ingredients were administered together, the independent contribution of pterostilbene and broader clinical benefit cannot be determined.
Citation: Dellinger et al., npj Aging and Mechanisms of Disease 3 (2017), 17. PMID: 29184669.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
100 g
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Strain & Enzyme System Development
An engineered microbial host strain is constructed carrying the biosynthetic gene cassette (tyrosine ammonia-lyase, coumarate-CoA ligase, stilbene synthase) together with a resveratrol O-methyltransferase (ROMT), enabling downstream conversion to pterostilbene.
Fermentation to Resveratrol Precursor
The engineered strain is fermented under controlled conditions, converting a tyrosine/p-coumaric acid feedstock through the stilbene synthase pathway to accumulate resveratrol as the key intermediate.
Enzymatic Bio-Methylation
The resveratrol intermediate undergoes SAM-dependent, two-step enzymatic O-methylation catalyzed by ROMT, selectively installing methoxy groups at the 3,5-positions to yield pterostilbene while preserving the 4'-hydroxyl.
Cell Harvest & Extraction
Fermentation broth is harvested and the biomass is disrupted; pterostilbene is extracted from the cell mass and clarified broth using solvent extraction.
Purification & Decolorization
Crude extract is purified through chromatographic/adsorption separation and activated-carbon decolorization to remove residual pigments, proteins, and process-related impurities.
Crystallization
The purified concentrate is crystallized under controlled cooling to obtain pterostilbene crystals of defined polymorphic form and particle characteristics.
Drying & Micronization
Crystals are vacuum-dried to the target moisture specification and milled/sieved to achieve a uniform, free-flowing fine powder.
QC Testing & Packaging
Finished powder is tested against full release specifications (assay, heavy metals, microbial limits) before being packed under moisture-protective conditions for shipment.
Purity is determined by reversed-phase HPLC against a certified pterostilbene reference standard, typically with UV detection around 306 nm, and reported on an as-is (non-volatile) basis. Buyers should request the full Certificate of Analysis for each lot, confirm the exact HPLC method (column, mobile phase, wavelength) used, and specify any additional identity confirmation (e.g., IR or mass spectrometry) required for their internal qualification.
Current commercial pterostilbene supplements are represented primarily by hard capsules. Because pterostilbene is poorly water-soluble, development should verify dissolution, carrier and excipient compatibility, content uniformity and target-market dose and claim limits.
Each batch is tested by HPLC against a certified reference standard and reported on the Certificate of Analysis (COA) issued with every shipment; buyers are welcome to request the COA and supporting chromatogram before or after purchase.
It is produced on PathGene's synthetic-biology and enzymatic production platform: engineered microbial fermentation generates a resveratrol precursor, which is then converted to pterostilbene via enzymatic O-methylation, followed by extraction, purification, and crystallization.
Pterostilbene is only slightly soluble in water but soluble in ethanol; for aqueous applications we recommend co-solvents, emulsification, or cyclodextrin complexation, while solid-dose formats can typically use the powder directly. See our solubility/formulation guidance for more detail.
Yes, small evaluation samples are available on request for qualified B2B buyers to verify appearance, solubility, and analytical results before committing to a bulk purchase.
Yes, buyers may send retained samples to an independent third-party laboratory of their choice for verification of purity, heavy metals, or microbial limits, and we can provide historical COAs to support the process.
Yes, PathGene supports OEM/private-label formatting, including custom blends, encapsulation/tableting coordination with partner facilities, and customer-branded packaging and documentation.
Standard packaging is in moisture-proof, light-protected bags/drums (e.g., 1 kg, 5 kg, 25 kg), with custom packaging available for larger or OEM orders. MOQ and pricing depend on order volume and specification requirements — please contact us for a formal quotation.
Assay is run by reversed-phase HPLC with UV detection around 306 nm against a certified pterostilbene reference standard; buyers who need the exact column/mobile-phase parameters can request the full analytical method summary alongside the COA.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
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