SAG
CAS 3054-47-5
Purity≥98.0%
S-acetyl glutathione for glutathione-derivative formulation research
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore nutrition & functional ingredients.
Confirm S-acetyl identity and conversion/assay method.
Key Specifications
| Product Positioning | S-acetyl glutathione for glutathione-derivative formulation research |
| Application Scenarios | glutathione-derivative research · oral solid-dose screening · redox formulation work |
| CAS Number | 3054-47-5 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₂H₁₉N₃O₇S |
| Molecular Weight | 349.36 g/mol |
| Appearance | White to off-white powder |
| Solubility | Soluble in water |
| Storage | 2–8°C, protect from light |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
S-Acetyl-L-Glutathione (SAG, CAS 3054-47-5) is a chemically modified derivative of the tripeptide glutathione (γ-L-glutamyl-L-cysteinyl-glycine), in which an acetyl group is attached to the sulfur atom of the cysteine thiol. Molecular formula C12H19N3O7S, MW 349.36 g/mol. Free glutathione is ubiquitous in living cells as the principal intracellular antioxidant, but its reactive thiol is unstable and poorly absorbed orally; S-acetylation caps this thiol, giving a product not itself abundant in nature but designed for improved chemical stability and cellular uptake. Commercial bulk material is produced semi-synthetically: glutathione feedstock is first generated by microbial fermentation (e.g., Saccharomyces cerevisiae), extracted and purified, then selectively S-acetylated under controlled conditions, followed by crystallization and drying to a high-purity powder.
High-Purity Assurance (≥98.0% HPLC)
Every batch of PathGene S-Acetyl-L-Glutathione is manufactured to a minimum assay of ≥98.0% by HPLC, with tight control over residual free glutathione and oxidized glutathione (GSSG) to ensure consistent potency batch to batch.
Controlled Fermentation-to-Acetylation Route
Glutathione feedstock is produced via a validated microbial fermentation platform and converted to SAG through a tightly monitored chemoselective S-acetylation process, giving full traceability from raw material to finished ingredient.
Consistent White to Off-White Powder
SAG is supplied as a free-flowing white to off-white crystalline powder with controlled particle size and low residual moisture, supporting reliable weighing, blending, and downstream formulation.
Full Contaminant & Microbial Screening
Each lot is screened for heavy metals (Pb, Hg, Cd, As), microbial limits (total plate count, yeast/mold, E. coli, Salmonella), and residual solvents, with certificates of analysis available for every shipment.
Flexible Bulk & OEM Supply
Available in bulk drum/bag packaging or custom OEM/private-label formats, with flexible order quantities from sample size to multi-ton, supported by strict internal quality control.
| Molecular Formula | C₁₂H₁₉N₃O₇S |
| Molecular Weight | 349.36 g/mol |
| Appearance | White to off-white powder |
| Solubility | Soluble in water |
| Storage Condition | 2–8°C, protect from light |
| Shelf Life | 24 months |
| Grade 1 | Supplement Grade · ≥98.0% · COA |
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Assay (HPLC) | ≥98.0% |
| Free Glutathione (related substance) | ≤1.0% |
| Loss on Drying | ≤0.5% |
| pH (1% aqueous solution) | 3.0–5.0 |
| Specific Rotation | -30° to -34° (c=1, H2O) |
| Heavy Metals (Pb) | ≤10 ppm |
| Mercury (Hg) | ≤1 ppm |
| Cadmium (Cd) | ≤1 ppm |
| Arsenic (As) | ≤2 ppm |
| Total Plate Count | ≤1000 CFU/g |
| Yeast & Mold | ≤100 CFU/g |
| E. coli | Negative/25 g |
| Salmonella | Negative/25 g |
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
Vitamin C is commonly used alongside glutathione ingredients in antioxidant formulas. For S-acetyl-L-glutathione, evaluate compatibility, oxidation control and dosage; direct clinical evidence for this exact combination remains unconfirmed.
Evidence: Formulation/indirect evidence only: human research supports oral S-acetyl-glutathione exposure, but a direct S-acetyl-glutathione + vitamin C efficacy trial was not confirmed.Source
Literature-Supported Research Directions
S-acetyl-L-glutathione is a glutathione-related derivative suited to studies of cellular reducing capacity, oxidative stress and delivery stability. Evidence for oral glutathione cannot be directly generalized to S-acetyl products; stability, conversion and bioavailability require product-specific validation.
Citation: Morris et al., Nutrients (2019), review of glutathione homeostasis and precursor-nutrient strategies.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
100 g
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Insulated Box + Carton
For products requiring temperature-controlled transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Fermentation of Glutathione Feedstock
A high-yield strain of Saccharomyces cerevisiae (or comparable production microorganism) is cultivated in a fed-batch fermenter using glucose/molasses-based media, biosynthesizing reduced glutathione (GSH) intracellularly.
Cell Harvest & Disruption
Fermentation broth is separated to recover the yeast biomass, which is then disrupted (autolysis or mechanical homogenization) to release intracellular glutathione into solution.
Extraction & Primary Purification of GSH
The crude lysate is clarified, concentrated, and purified (e.g., by ion-exchange and crystallization) to obtain high-purity reduced glutathione as the acetylation feedstock.
Chemoselective S-Acetylation
Purified glutathione is reacted with an acetylating agent (typically acetic anhydride) under controlled pH, temperature, and mild acid catalysis, selectively acylating the cysteine thiol (-SH) while leaving the free amino and carboxyl groups unreacted.
Reaction Quench & Byproduct Removal
The reaction is quenched, excess acetic anhydride and the acetic acid byproduct are removed, and the crude S-acetylglutathione solution is neutralized.
Crystallization
The crude product is crystallized from the neutralized solution under controlled cooling, and the resulting crystals are separated by filtration.
Recrystallization & Polishing
The crude crystals undergo one or more recrystallization/polishing steps to remove residual free glutathione, oxidized glutathione (GSSG), and process-related impurities, raising purity to ≥98.0%.
Drying, Milling, QC & Packaging
Purified crystals are vacuum-dried, milled to the target particle size, tested against full quality specifications (assay, heavy metals, microbial limits), and packaged under moisture-protected conditions.
Purity is determined by reverse-phase HPLC with UV detection against a certified S-Acetyl-L-Glutathione reference standard, with related substances (free glutathione, GSSG, and other process impurities) quantified in the same run. Buyers should confirm the reference standard source, column/method parameters, and acceptance criteria for free glutathione and residual solvents (e.g., acetic acid) when reviewing the Certificate of Analysis, and may request an independent HPLC or LC-MS verification for critical applications.
S-Acetyl-L-Glutathione is soluble in water, allowing it to be formulated as clear aqueous solutions, effervescent/dissolvable powders, sachets, or encapsulated in hard-shell capsules and tablets. Because the S-acetyl (thioester) bond can be hydrolyzed under strongly alkaline or oxidizing conditions, formulators are advised to keep aqueous preparations near neutral to mildly acidic pH, avoid prolonged heat exposure, and store finished products in light-protected, moisture-controlled packaging to preserve potency through shelf life.
PathGene supplies S-Acetyl-L-Glutathione at a minimum assay of 98.0% by HPLC. Each lot ships with a Certificate of Analysis covering assay, related substances, heavy metals, and microbial limits; the underlying HPLC chromatogram or additional testing data can be provided on request.
The glutathione feedstock is produced by microbial fermentation, then converted to S-Acetyl-L-Glutathione through a controlled chemical S-acetylation step that selectively caps the reactive thiol group. This combined bio-fermentation-plus-acetylation route is the standard commercial process for this ingredient.
Yes, it is soluble in water. It is commonly formulated into capsules, tablets, sachets, or ready-to-mix powders; we recommend keeping aqueous formulations near neutral pH and avoiding prolonged heat or strongly alkaline processing to protect the acetyl-thioester bond.
Yes, small evaluation samples are available on request so your team can run in-house identity, purity, and formulation compatibility testing before committing to a bulk purchase.
Yes. In addition to our internal CoA, we accommodate customer-designated third-party laboratory testing on sample or bulk shipments, and can assist with sample submission for independent HPLC, heavy metal, or microbial analysis.
Yes, we support OEM/private-label supply, including custom packaging, labeling, and formulation-ready blends (e.g., pre-mixed powders or capsule fills) tailored to your brand and market requirements.
Standard packaging is in moisture-resistant, light-protected bags or drums (e.g., 1 kg, 5 kg, 25 kg) with an inner food/pharma-grade liner; custom packaging sizes and materials can be arranged for larger contracts.
Minimum order quantities are flexible and depend on packaging format and destination; please share your target quantity, application, and delivery location so our team can prepare a formal quotation and lead time.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Technical Resources
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Interested in SAG?
Our R&D team will respond to your inquiry or sample request within 24 hours.
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Alex Huang · Mon–Fri 9am–6pm CST
