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SAG

CAS 3054-47-5

S-Acetyl-L-Glutathione Powder

Name: S-Acetyl-L-Glutathione Powder
Brand: PathGene

Purity≥98.0%

S-acetyl glutathione for glutathione-derivative formulation research

S-Acetyl-L-Glutathione Powder (CAS 3054-47-5), specification ≥98.0%. S-Acetyl-L-glutathione, abbreviated SAG, with its own ingredient identity and specifications, separate from ordinary GSH. Batch COA and evaluation samples are available. MOQ: 100 g. nutrition & functional ingredients

Quote / sample & delivery

MW349.36 g/mol

S-Acetyl-L-Glutathione Powder (CAS 3054-47-5) bulk active ingredient

Key Specifications

Product Positioning	S-acetyl glutathione for glutathione-derivative formulation research
Application Scenarios	glutathione-derivative research · oral solid-dose screening · redox formulation work
CAS Number	3054-47-5
Purity	≥98.0%
Molecular Formula	C₁₂H₁₉N₃O₇S
Molecular Weight	349.36 g/mol
Appearance	White to off-white powder
Solubility	Soluble in water
Storage	2–8°C, protect from light
Shelf Life	24 months

Procurement & delivery

Supply details confirmed by intended use, volume and target market

Purity ≥98.0%CAS 3054-47-5

MOQ100 g

Lead Time3–5 business days

Packaging100 g / 500 g / 1 kg

Free sample available

View quality documents ↓

What Is SAG?

S-Acetyl-L-Glutathione (SAG, CAS 3054-47-5) is a chemically modified derivative of the tripeptide glutathione (γ-L-glutamyl-L-cysteinyl-glycine), in which an acetyl group is attached to the sulfur atom of the cysteine thiol. Molecular formula C12H19N3O7S, MW 349.36 g/mol. Free glutathione is ubiquitous in living cells as the principal intracellular antioxidant, but its reactive thiol is unstable and poorly absorbed orally; S-acetylation caps this thiol, giving a product not itself abundant in nature but designed for improved chemical stability and cellular uptake. Commercial bulk material is produced semi-synthetically: glutathione feedstock is first generated by microbial fermentation (e.g., Saccharomyces cerevisiae), extracted and purified, then selectively S-acetylated under controlled conditions, followed by crystallization and drying to a high-purity powder.

Other Names

S-AcetylglutathioneAcetylglutathioneSAGS-Acetyl-GSHγ-Glutamyl-S-acetylcysteinylglycineN-(N-γ-L-Glutamyl-S-acetyl-L-cysteinyl)glycineS-Acetyl-L-glutathioneCAS 3054-47-5

Key Features

🎯

High-Purity Assurance (≥98.0% HPLC)

Every batch of PathGene S-Acetyl-L-Glutathione is manufactured to a minimum assay of ≥98.0% by HPLC, with tight control over residual free glutathione and oxidized glutathione (GSSG) to ensure consistent potency batch to batch.

🧬

Controlled Fermentation-to-Acetylation Route

Glutathione feedstock is produced via a validated microbial fermentation platform and converted to SAG through a tightly monitored chemoselective S-acetylation process, giving full traceability from raw material to finished ingredient.

⚪

Consistent White to Off-White Powder

SAG is supplied as a free-flowing white to off-white crystalline powder with controlled particle size and low residual moisture, supporting reliable weighing, blending, and downstream formulation.

🧪

Full Contaminant & Microbial Screening

Each lot is screened for heavy metals (Pb, Hg, Cd, As), microbial limits (total plate count, yeast/mold, E. coli, Salmonella), and residual solvents, with certificates of analysis available for every shipment.

📦

Flexible Bulk & OEM Supply

Available in bulk drum/bag packaging or custom OEM/private-label formats, with flexible order quantities from sample size to multi-ton, supported by ISO-certified manufacturing.

Molecular Formula	C₁₂H₁₉N₃O₇S
Molecular Weight	349.36 g/mol
Appearance	White to off-white powder
Solubility	Soluble in water
Storage Condition	2–8°C, protect from light
Shelf Life	24 months
Grade 1	Supplement Grade · ≥98.0% · COA

Specification limits (not batch test results)
Test Item	Specification
Appearance	White to off-white crystalline powder
Assay (HPLC)	≥98.0%
Free Glutathione (related substance)	≤1.0%
Loss on Drying	≤0.5%
pH (1% aqueous solution)	3.0–5.0
Specific Rotation	-30° to -34° (c=1, H2O)
Heavy Metals (Pb)	≤10 ppm
Mercury (Hg)	≤1 ppm
Cadmium (Cd)	≤1 ppm
Arsenic (As)	≤2 ppm
Total Plate Count	≤1000 CFU/g
Yeast & Mold	≤100 CFU/g
E. coli	Negative/25 g
Salmonella	Negative/25 g

Applicable Dosage Forms

Hard capsules

Powder and functional beverage formulation

Powders

Softgels

Tablets

Sublingual tablets

Oral dissolving films

S-acetyl glutathione development essentials

The acetylated structure differs from GSH; do not directly transplant GSH assays or human findings.

Composition candidates:: Screen fillers and vitamin-C preblends for solids; assay the acetylated compound, GSH and impurities separately.
Processing priorities:: Compare moisture, acidity, heat exposure and packaging, tracking acetyl-related changes and dissolution.
Testing priorities:: S-acetyl glutathione assay, free GSH, related substances and content uniformity.

Review lot COA ↗Explore formulation and combination research ↓

S-acetyl glutathione formulation development: composition, processing and validation

Composition candidates, processing sequences and tests support pilot design. Confirm candidate excipients and processes using this material in the actual finished formulation.

Solid formats: carriers, loading and mixing

Define loading by ingredient mass, salt mass or active moiety. Use m = target mass / assay as supplied only when both share the same basis; convert dried-basis assays using water where appropriate, and do not substitute HPLC area purity for mass assay. Set excipient amounts from fill mass, bulk density and uniformity trials.
Screen fillers and vitamin-C preblends for solids; assay the acetylated compound, GSH and impurities separately.
Record ingredient lots, actual component masses, loading bases and addition sequence, retaining blanks and single-ingredient controls for traceable changes.

Processing and formats: pilot batches through filling

Compare moisture, acidity, heat exposure and packaging, tracking acetyl-related changes and dissolution.
Select blending/filling equipment for the actual format, recording size, bulk density, mixing time and fill mass; liquid or softgel routes need separate carrier, sedimentation and container/shell compatibility testing.

Validation and scale-up: tests, retained samples and packaging

S-acetyl glutathione assay, free GSH, related substances and content uniformity.
Sample upper/middle/lower positions and start/middle/end filling; compare with ingredients, process blanks and single-ingredient results, documenting deviations and corrections.
Include actual packaging, transport and intended storage in retained-sample plans; ingredient COAs and storage conditions do not establish a new finished-product shelf life.

Literature-informed combinations and development insights

Application examples follow the materials, formats and findings actually studied. Combination studies, single-ingredient studies, commercial precedents and development candidates are distinguished.

Single-ingredient and standardized-material applications

Randomized controlled human study

Oral crystalline S-acetyl glutathione: a 2026 controlled study

SAG and reduced GSH are distinct materials; oral beauty development should compare material, loading and measured endpoints.

Show research and formulation insights +

Combination / selection rationale: SAG and reduced GSH are distinct materials; oral beauty development should compare material, loading and measured endpoints.

Published evidence / source details: An October 2026 trial assigned 90 women to SAG 200 mg/day, GSH 500 mg/day or placebo for 12 weeks. Melanin-index changes differed despite baseline imbalance; pigmentation ratings and GSH levels did not differ significantly between groups.

Development insights: Specify acetyl identity, physical form and assay, then test uniformity, disintegration/dissolution and packaged stability. Prespecify instrument, subjective and GSH endpoints separately instead of generalizing one change to overall superiority.

Evidence scope: A specific commercial crystalline material, not validation of this lot; unequal doses do not establish comparative absorption.

2026 · SAG versus GSH placebo-controlled study · DOI 10.1111/jocd.71223 ↗

Reaction systems and analytical applications

Original matrix-conversion study

SAG/GSH conversion: analytical separation and sample handling

Acetyl-related conversion affects interpretation, requiring separate SAG, GSH and impurity measurements.

Show research and formulation insights +

Combination / selection rationale: Acetyl-related conversion affects interpretation, requiring separate SAG, GSH and impurity measurements.

Published evidence / source details: A 1994–1995 study in rat plasma, erythrocytes and tissue preparations found matrix-dependent SAG hydrolysis and changes in intracellular GSH.

Development insights: Validate SAG/GSH separation and recovery; biological samples need time-to-extraction, temperature and matrix blanks. Track SAG retention alongside GSH formation to distinguish formulation conversion from sample-preparation artifacts.

Evidence scope: Ex vivo animal-matrix evidence, not a human oral-bioavailability multiplier or shelf-life specification.

1994–1995 · S-acetyl- and S-phenylacetyl-glutathione as glutathione precursors in rat plasma and tissue preparations. · DOI 10.1159/000474975 ↗

Formulation development candidates

Animal multicomponent study / candidate

SAG + vitamin C: separate ingredient controls in a candidate blend

Vitamin C and SAG form a redox-development candidate requiring separate assays for acetylated material, free GSH and ascorbic acid.

Show research and formulation insights +

Combination / selection rationale: Vitamin C and SAG form a redox-development candidate requiring separate assays for acetylated material, free GSH and ascorbic acid.

Published evidence / source details: A 2023 randomized blinded dog pilot tested a multicomponent SAG/antioxidant supplement for 35 days and reported higher GPx, without isolating SAG/vitamin-C contributions.

Development insights: Premix separately and compare singles, blend and carrier blanks. Track each active and degradants under target moisture, acidity and packaging; aqueous work also records pH, colour and hold time beyond total antioxidant assays.

Evidence scope: Animal multicomponent evidence supports exploration, not exact-blend human synergy.

2023 · SAG-containing antioxidant supplement in healthy dogs · DOI 10.1080/1828051X.2023.2221073 ↗

Manufacturing Process

Fermentation of Glutathione Feedstock

A high-yield strain of Saccharomyces cerevisiae (or comparable production microorganism) is cultivated in a fed-batch fermenter using glucose/molasses-based media, biosynthesizing reduced glutathione (GSH) intracellularly.

Cell Harvest & Disruption

Fermentation broth is separated to recover the yeast biomass, which is then disrupted (autolysis or mechanical homogenization) to release intracellular glutathione into solution.

Extraction & Primary Purification of GSH

The crude lysate is clarified, concentrated, and purified (e.g., by ion-exchange and crystallization) to obtain high-purity reduced glutathione as the acetylation feedstock.

Chemoselective S-Acetylation

Purified glutathione is reacted with an acetylating agent (typically acetic anhydride) under controlled pH, temperature, and mild acid catalysis, selectively acylating the cysteine thiol (-SH) while leaving the free amino and carboxyl groups unreacted.

Reaction Quench & Byproduct Removal

The reaction is quenched, excess acetic anhydride and the acetic acid byproduct are removed, and the crude S-acetylglutathione solution is neutralized.

Crystallization

The crude product is crystallized from the neutralized solution under controlled cooling, and the resulting crystals are separated by filtration.

Recrystallization & Polishing

The crude crystals undergo one or more recrystallization/polishing steps to remove residual free glutathione, oxidized glutathione (GSSG), and process-related impurities, raising purity to ≥98.0%.

Drying, Milling, QC & Packaging

Purified crystals are vacuum-dried, milled to the target particle size, tested against full quality specifications (assay, heavy metals, microbial limits), and packaged under moisture-protected conditions.

Purity & Assay Method

Purity is determined by reverse-phase HPLC with UV detection against a certified S-Acetyl-L-Glutathione reference standard, with related substances (free glutathione, GSSG, and other process impurities) quantified in the same run. Buyers should confirm the reference standard source, column/method parameters, and acceptance criteria for free glutathione and residual solvents (e.g., acetic acid) when reviewing the Certificate of Analysis, and may request an independent HPLC or LC-MS verification for critical applications.

Solubility & Formulation

S-Acetyl-L-Glutathione is soluble in water, allowing it to be formulated as clear aqueous solutions, effervescent/dissolvable powders, sachets, or encapsulated in hard-shell capsules and tablets. Because the S-acetyl (thioester) bond can be hydrolyzed under strongly alkaline or oxidizing conditions, formulators are advised to keep aqueous preparations near neutral to mildly acidic pH, avoid prolonged heat exposure, and store finished products in light-protected, moisture-controlled packaging to preserve potency through shelf life.

What is the specification for S-Acetyl-L-Glutathione powder?+

S-Acetyl-L-Glutathione powder has an HPLC assay specification of ≥98.0%. The specification defines agreed tests and limits, while the offered lot COA documents actual results. HPLC chromatograms and additional testing information are arranged according to the documentation requested.

How is this ingredient manufactured — is it fermentation-based or fully synthetic?+

The glutathione feedstock is produced by microbial fermentation, then converted to S-Acetyl-L-Glutathione through a controlled chemical S-acetylation step that selectively caps the reactive thiol group. This combined bio-fermentation-plus-acetylation route is the standard commercial process for this ingredient.

Is S-Acetyl-L-Glutathione water soluble, and how should it be formulated?+

Yes, it is soluble in water. It is commonly formulated into capsules, tablets, sachets, or ready-to-mix powders; we recommend keeping aqueous formulations near neutral pH and avoiding prolonged heat or strongly alkaline processing to protect the acetyl-thioester bond.

Can we request a free sample before placing a bulk order?+

Yes, small evaluation samples are available on request so your team can run in-house identity, purity, and formulation compatibility testing before committing to a bulk purchase.

Can S-Acetyl-L-Glutathione be independently tested?+

Customer-designated laboratories can independently test S-Acetyl-L-Glutathione samples. Agree sampling, the HPLC assay basis and any required heavy-metal or microbiological tests, then compare results with the offered lot specification and COA.

Do you offer OEM or private-label services?+

Yes, we support OEM/private-label supply, including custom packaging, labeling, and formulation-ready blends (e.g., pre-mixed powders or capsule fills) tailored to your brand and market requirements.

Which pack sizes are available for S-Acetyl-L-Glutathione powder?+

S-Acetyl-L-Glutathione powder pack options are 100 g, 500 g, 1 kg. Special inner-packaging, labeling and transport requirements are agreed separately for the order.

What are the MOQ and pack options for S-Acetyl-L-Glutathione powder?+

The raw-material MOQ for S-Acetyl-L-Glutathione powder is 100 g, with pack options of 100 g, 500 g, 1 kg. Typical lead time is 3–5 business days, with dispatch confirmed for the order.

Can reduced-glutathione findings be used for S-acetyl glutathione?+

They are distinct materials. Match acetyl identity, physical form, assay and the formulation actually studied. A 2026 trial compared specific oral SAG and GSH products at different doses with endpoint-dependent findings; it does not establish a universal absorption multiplier or validate every SAG powder. Assay SAG, free GSH and related substances separately.

Why Choose PathGene

Direct China manufacturer supply — factory pricing, no middleman
Product specification sheet available; confirm recent-batch COA with sales
In-house R&D + synthetic biology / enzymatic production platform
Free sample for qualified B2B buyers before commercial order
Flexible MOQ — from lab-scale trial to ton-scale commercial supply
One-stop OEM/private-label support for finished dosage forms
Worldwide shipping by courier, air freight, and sea freight

OEM & Private-Label Services

·Custom capsule manufacturing
·Custom tablet manufacturing
·Powder blending & custom formulation
·Private-label bottles, pouches & labels
·Small trial orders
·Bulk commercial production
·Export documentation
·Third-party testing support available on request

Documents Available

·Product specification sheet — request from sales
·Recent-batch COA — confirm with sales by product and batch
·Other quality documents — confirm by product and batch

Documents are subject to product and batch availability; third-party reports are provided only when applicable.

Quality documents

Review specifications first, then batch data at shipment

The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.

Product specification

Stable acceptance criteria · Available on request

Technical Resources

SAG Technical Articles

View all articles →

Reduced Glutathione Stability: Oxidation, pH and Batch Assay

Review reduced glutathione oxidation, liquid-formulation conditions and separate purity, assay and GSSG results before bulk purchasing.

S-Acetyl-Glutathione Exists to Solve a Problem With Plain Glutathione — Here's What That Problem Actually Is

If you've read our post on why reduced glutathione oxidizes so readily, S-Acetyl-L-Glutathione is the direct answer to that problem — a deliberately engineered modification, not a naturally abundant compound. Here's how it actually works.

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Interested in SAG?

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What Is SAG?

Key Features

🎯

High-Purity Assurance (≥98.0% HPLC)

🧬

Controlled Fermentation-to-Acetylation Route

⚪

Consistent White to Off-White Powder

SAG is supplied as a free-flowing white to off-white crystalline powder with controlled particle size and low residual moisture, supporting reliable weighing, blending, and downstream formulation.

🧪

Full Contaminant & Microbial Screening

📦

Flexible Bulk & OEM Supply

Available in bulk drum/bag packaging or custom OEM/private-label formats, with flexible order quantities from sample size to multi-ton, supported by ISO-certified manufacturing.

Why Choose PathGene

Direct China manufacturer supply — factory pricing, no middleman

Product specification sheet available; confirm recent-batch COA with sales

In-house R&D + synthetic biology / enzymatic production platform

Free sample for qualified B2B buyers before commercial order

Flexible MOQ — from lab-scale trial to ton-scale commercial supply

One-stop OEM/private-label support for finished dosage forms

Worldwide shipping by courier, air freight, and sea freight

S-Acetyl-L-Glutathione Powder

What Is SAG?

Other Names