1-MNA
CAS 1005-24-9
Purity≥98.5% (dried basis)
Nicotinamide metabolite salt for analytical and biochemical research
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore NAD+ ingredients.
Confirm chloride salt and 1-methylnicotinamide assay basis.
Key Specifications
| Product Positioning | Nicotinamide metabolite salt for analytical and biochemical research |
| Application Scenarios | nicotinamide-metabolite assays · vascular-biology research · analytical reference development |
| CAS Number | 1005-24-9 |
| Purity | ≥98.5% (dried basis) |
| Molecular Formula | C7H9N2OCl |
| Molecular Weight | 172.6 g/mol |
| Appearance | White to off-white crystalline solid |
| Solubility | Soluble in water and methanol |
| Storage | Store in a well-closed and dry place at room temperature, away from direct sunlight. |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
1-Methylnicotinamide chloride (1-MNA, CAS 1005-24-9) is a defined nicotinamide derivative supplied as a crystalline chloride salt. The referenced batch is documented by HPLC assay, identity, water, impurities, residual solvent and microbiological testing for formulation and research qualification.
99.5% HPLC Assay in the Referenced Batch
The referenced batch PGMNC-260718 reports 99.5% assay by HPLC on a dried basis against a 98.5%–101.5% specification.
Defined Crystalline Chloride Salt
Supplied as 1-Methylnicotinamide chloride, a defined crystalline salt for formulation and research qualification.
Batch Quality Profile
The referenced COA records identity, water, loss on drying, heavy metals, impurities, residual solvent and microbiological checks.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGMNC-260718
Test date
2026-07-18
Specification
In-house
Pack size
10 kg/bag
Storage
Store in a well-closed and dry place at room temperature, away from direct sunlight.
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white crystalline solid | Conforms |
| Identification | ¹H NMR confirms structure | Conforms |
| Solubility | Soluble in water and methanol | Conforms |
| Assay (HPLC, dry basis) | 98.5%–101.5% | 99.5% |
| Loss on drying | ≤1.0% | 0.16% |
| Water | ≤0.3% | 0.11% |
| Residue on ignition | ≤0.1% | 0.03% |
| Heavy metals | ≤20 ppm | ≤10 ppm |
| Trigonelline | ≤0.05% | Not detected |
| Nicotinic acid | ≤0.10% | Not detected |
| Nicotinamide | ≤0.10% | Not detected |
| Largest unknown impurity | ≤0.05% | 0.01% |
| Total unknown impurities | ≤0.20% | 0.01% |
| Total impurities | ≤0.50% | 0.01% |
| Residual methanol | ≤0.3% | 0.028% |
| Total plate count | ≤100 CFU/g | ≤10 CFU/g |
| Yeasts and moulds | ≤10 CFU/g | ≤10 CFU/g |
| Pathogens | Absence in 1 g | Not detected |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
A single-ingredient hard capsule matches an established commercial format and avoids implying an unverified synergistic pairing.
Evidence: Commercial-format evidence: Endotelio markets a vegan capsule containing 29 mg of 1-MNA. Finished-product dose and eligibility remain market-specific.Source
Literature-Supported Research Directions
N¹-Methylnicotinamide (MNAM) is generated when nicotinamide is methylated by NNMT. It is a downstream metabolite connected to nicotinamide clearance, one-carbon metabolism and NAD⁺ salvage-pathway balance; it should not be described as a direct NAD⁺ precursor.
Citation: Matuszewska et al., NAD⁺ metabolism and its roles in cellular processes during ageing (2021 review).View source
In a human vascular study, oral MNAM increased brachial-artery flow-mediated dilation and enhanced NO release from cultured human endothelial cells. This supports research into endothelial redox balance, eNOS function and vascular responsiveness.
Citation: Surdacki et al., Pharmacological Research (2012), human blood-vessel endothelial function study.View source
Preclinical studies associate MNAM with prostacyclin- and NO-dependent endothelial signaling, lower platelet activation and reduced inflammatory burden in atherosclerosis models. These are model-based research findings, not a clinical antithrombotic indication.
Citation: Kowaluk et al., Antiatherosclerotic Effects of 1-Methylnicotinamide (2016), ApoE/LDLR-deficient mouse model.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
Contact us
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Assay/purity is reported against the referenced batch COA; request the current lot documentation before qualification.
A marketed single-ingredient hard-capsule format is available. Confirm capsule-shell compatibility, moisture control, serving level, target-market authorization and label restrictions before scale-up.
1-Methylnicotinamide Chloride (1-MNA) is a defined nicotinamide derivative supplied as a crystalline chloride salt. Its CAS number is 1005-24-9, formula C7H9N2OCl, and molecular weight 172.6 g/mol. The identity is documented by 1H NMR in the referenced COA.
The referenced batch PGMNC-260718 reports 99.5% assay by HPLC on the dried basis. The specification range is 98.5%–101.5% on the dried basis.
The COA checks trigonelline, nicotinic acid, nicotinamide, unknown impurities, total impurities and residual methanol. The referenced batch reports total impurities of 0.01% and residual methanol of 0.028%.
The referenced COA describes 1-MNA as soluble in water and methanol. Confirm concentration, pH and compatibility in the target formulation before scale-up.
The referenced COA lists 10 kg/bag packaging. Store in a well-closed, dry place at room temperature and protect from direct sunlight. Confirm current pack size and shipping conditions when requesting a quote.
Buyers can request the current batch COA, product specification and SDS/TDS as applicable. The lot-specific COA should be used for final assay, impurity and microbiological review.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Related Products
β-Nicotinamide Mononucleotide
β-Nicotinamide Adenine Dinucleotide
Nicotinamide Riboside Chloride
Nicotinamide Riboside Hydrogen Malate
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