NMN
β-Nicotinamide Mononucleotide
Key Specifications
| CAS Number | 1094-61-7 |
| Purity | ≥99.5% |
| Molecular Formula | C₁₁H₁₅N₂O₈P |
| Molecular Weight | 334.22 g/mol |
| Appearance | White to off-white crystalline powder |
| Solubility | Freely soluble in water |
| Storage | ≤-20°C, protect from light and moisture |
| Shelf Life | 24 months |
CAS 1094-61-7
What Is NMN?
β-Nicotinamide mononucleotide (NMN, CAS 1094-61-7, C11H15N2O8P, MW 334.22 g/mol) is a naturally occurring nucleotide formed from nicotinamide, ribose, and a phosphate group. It occurs in trace amounts in foods such as broccoli, edamame, cabbage, and cucumber, and serves as a direct biosynthetic precursor of NAD+ (nicotinamide adenine dinucleotide), a coenzyme central to cellular energy metabolism and redox signaling. Because natural abundance is far too low for commercial extraction, bulk NMN used in supplements, cosmetic actives, and pharmaceutical-grade materials is manufactured through enzymatic/biocatalytic conversion: engineered microbial enzymes (e.g., nicotinamide riboside kinase or nicotinamide phosphoribosyltransferase), paired with an ATP-regeneration system, convert precursor substrates into NMN, which is then purified and crystallized to achieve high-purity powder form.
Other Names
Key Features
≥99.5% Verified Purity
HPLC-verified purity at or above 99.5%, meeting USP/EP monograph-level expectations with batch-to-batch consistency confirmed by COA.
Immobilized Enzyme Production, No Chloride Contamination
Produced via a controlled immobilized-enzyme biocatalytic process rather than chlorinated chemical routes, minimizing chloride ion residues and other process-related impurities.
Consistent Crystalline Powder
Uniform white to off-white crystalline powder with controlled particle size, freely soluble in water for easy handling in downstream formulation.
Full Contaminant & Microbial Screening
Every batch is screened for heavy metals (Pb, Hg, Cd, As), residual solvents, and microbial limits (total plate count, yeast/mold, E. coli, Salmonella) before release.
Flexible Bulk & OEM Supply
Available in flexible bulk quantities with OEM/private-label support, plus formulation guidance for capsules, sublingual tablets, sachets, and topical serums.
| Molecular Formula | C₁₁H₁₅N₂O₈P |
| Molecular Weight | 334.22 g/mol |
| Appearance | White to off-white crystalline powder |
| Solubility | Freely soluble in water |
| Storage Condition | ≤-20°C, protect from light and moisture |
| Shelf Life | 24 months |
| Grade 1 | Pharmaceutical Grade · ≥99.5% · USP/EP |
| Grade 2 | Food Grade · ≥98.0% · Food Safety |
End-Product Applications
Overview
NMN is the most direct oral precursor to NAD⁺, rapidly elevating intracellular NAD⁺ within 60 minutes of ingestion. PathGene's fixed-enzyme synthesis delivers zero Cl⁻ contamination and ≥99.5% purity.
Mechanism & Benefits
activates SIRT1/SIRT3 sirtuins → mitochondrial biogenesis, DNA repair, cellular energy metabolism
Typical Dosage
250–500 mg/serving in capsule/softgel
Compatible Formulations
capsule, sublingual tablet, powder sachet, IV solution (pharma grade), topical serum (0.1–0.5%)
Target Market
premium anti-aging supplement brands, longevity clinics, cosmeceutical lines targeting 35+ consumers
Packaging Options
1 kg 5 kg 25 kg
Lead Time
3–5 business days
Minimum Order
1 kg
Custom Packaging
Custom packaging (foil bags, HDPE drums), GMP labeling, and export documentation are available. Contact us for specifics.Certifications
USP
US Pharmacopoeia
EP
European Pharmacopoeia
ISO
ISO
ISO9001
ISO 9001
Associated Patents
ZL 2022 1 0234567.X
Granted Chinese Invention Patent — core synthesis process protected by IP, ensuring supply stability and proprietary process exclusivity.
+ PathGene holds 12 core invention patents in total
Manufacturing Process
Biocatalyst Fermentation
An engineered microbial strain expressing the target enzyme (e.g., nicotinamide riboside kinase or nicotinamide phosphoribosyltransferase) is cultivated by fermentation to produce the biocatalyst in a controlled bioreactor.
Enzyme Extraction & Immobilization
The enzyme is extracted, purified, and immobilized onto a solid carrier, enabling reuse across reaction cycles and reducing ionic and chemical residues compared with solution-phase chemical synthesis.
Substrate & Cofactor Preparation
Precursor substrate (nicotinamide riboside, or nicotinamide with 5-phosphoribosyl-1-pyrophosphate) is prepared alongside an ATP-regeneration system to sustain the phosphorylation/condensation reaction at scale.
Enzymatic Bioconversion
Under controlled temperature and pH, the immobilized enzyme catalyzes conversion of the substrate into NMN within a stirred-tank or packed-bed bioreactor, monitored for conversion yield in real time.
Biomass & Enzyme Carrier Removal
Reaction broth is clarified by filtration/centrifugation to separate the immobilized enzyme carrier and residual biomass from the product stream.
Purification & Ion Removal
The crude NMN solution undergoes chromatographic and/or ion-exchange purification to remove salts, chloride ions, and byproducts, concentrating the target compound.
Crystallization, Drying & Milling
Controlled crystallization yields high-purity NMN crystals, which are then vacuum-dried and milled to a consistent particle size for the finished powder.
Quality Control & Packaging
Finished batches are tested for assay (HPLC), heavy metals, and microbial limits, then packed under nitrogen-flushed, moisture-protected conditions with a batch COA.
Quality Specifications
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white crystalline powder | Conforms, white to off-white powder |
| Odor | Odorless or faint characteristic odor | Conforms |
| Assay (HPLC) | ≥99.5% | 99.6% |
| Identification (MS/NMR, formula confirmation) | Conforms to C11H15N2O8P | Conforms |
| Loss on Drying | ≤1.0% | 0.4% |
| pH (1% aqueous solution) | 6.0-7.5 | 6.8 |
| Residue on Ignition / Sulfated Ash | ≤0.5% | 0.2% |
| Heavy Metals - Lead (Pb) | ≤2 ppm | <1 ppm |
| Heavy Metals - Mercury (Hg) | ≤0.1 ppm | <0.05 ppm |
| Heavy Metals - Cadmium (Cd) | ≤1 ppm | <0.5 ppm |
| Heavy Metals - Arsenic (As) | ≤1 ppm | <0.5 ppm |
| Total Plate Count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mold | ≤100 CFU/g | <10 CFU/g |
| E. coli / Salmonella | Negative/25g | Negative |
Purity & Assay Method
Purity is determined by reverse-phase HPLC against a reference standard, with identity typically cross-confirmed by mass spectrometry or NMR. Buyers should request the current Certificate of Analysis for the specific batch and confirm the assay method, reference standard traceability, and any regional pharmacopeia alignment (USP/EP) relevant to their intended use, especially for pharmaceutical-grade applications.
Solubility & Formulation
NMN is freely soluble in water, which supports its use across a range of delivery formats including oral capsules and tablets, sublingual formats for faster mucosal absorption, effervescent or powder sachets, and, for pharmaceutical-grade material, sterile injectable solutions. For topical/cosmetic applications, NMN is typically incorporated at 0.1-0.5% in aqueous-phase serums or emulsions; formulators should evaluate pH stability and packaging light/oxygen protection, as NMN solutions may be sensitive to prolonged heat and light exposure.
Available Product Forms
Bulk NMN Powder
High-purity raw powder for supplement factories, research organizations, ingredient distributors, and contract manufacturers.
NMN Capsules
Custom capsule strength, shell material, bottle count, excipients, and label design for private-label brands.
NMN Tablets
Tablet formulation, granulation, compression, coating, bottle packaging, and custom labeling support.
NMN Powder Blends
NMN can be blended with complementary actives (antioxidants, other longevity ingredients, vitamins, minerals) per customer formula.
How is the ≥99.5% purity of your NMN verified?+
Each batch is tested by HPLC against a reference standard, with a Certificate of Analysis (COA) issued per batch. Buyers are welcome to request the COA for the specific lot before purchase, and third-party verification is supported.
How is your NMN produced — is it synthetic, fermented, or enzymatically made?+
Our NMN is produced via an immobilized-enzyme biocatalytic process, avoiding chlorinated chemical routes and their associated chloride ion residues. This enzymatic approach supports high purity and consistent batch-to-batch quality.
Is NMN soluble in water, and what formats can it be used in?+
Yes, NMN is freely soluble in water, making it suitable for capsules, sublingual tablets, powder sachets, and, at pharmaceutical grade, injectable solutions. It can also be incorporated into aqueous-phase cosmetic serums at 0.1-0.5%.
Can we request a sample before placing a bulk order?+
Yes, samples are available for qualified B2B buyers to evaluate purity, appearance, and solubility ahead of a bulk order. Please contact our sales team to arrange sample shipment and documentation.
Do you support third-party testing or independent lab verification?+
Yes, buyers are free to submit samples to third-party laboratories of their choice for independent verification of purity, heavy metals, and microbial limits. We are happy to cooperate with recognized testing bodies.
Do you offer OEM or private-label services for finished products?+
Yes, we support OEM/private-label collaboration, including formulation guidance for capsules, sublingual tablets, sachets, and topical serums, in addition to supplying bulk raw material.
What packaging options are available, and what is the MOQ for a quotation?+
NMN is typically packed in moisture-protected, nitrogen-flushed containers (e.g., 1 kg, 5 kg, or 25 kg drums), with custom packaging available on request. MOQ and pricing depend on quantity and grade (food/cosmetic vs. pharmaceutical); please contact us directly for a formal quotation.
Which certifications does your NMN comply with?+
Our NMN is produced and tested to meet USP and EP monograph expectations, manufactured under an ISO9001-certified quality system, with ISO-aligned process controls. Certification documents are available on request.
Why Choose PathGene
- Direct China manufacturer supply — factory pricing, no middleman
- Batch-specific COA & full traceability on every shipment
- In-house R&D + synthetic biology / enzymatic production platform
- Free sample for qualified B2B buyers before commercial order
- Flexible MOQ — from lab-scale trial to ton-scale commercial supply
- One-stop OEM/private-label support for finished dosage forms
- Worldwide shipping by courier, air freight, and sea freight
OEM & Private-Label Services
- ·Custom capsule manufacturing
- ·Custom tablet manufacturing
- ·Powder blending & custom formulation
- ·Private-label bottles, pouches & labels
- ·Small trial orders
- ·Bulk commercial production
- ·Export documentation
- ·Third-party laboratory testing
Documents Available
- ·Certificate of Analysis (COA)
- ·Product specification sheet
- ·Material Safety Data Sheet (MSDS)
- ·Manufacturing flow chart
- ·HPLC test report
- ·Heavy-metal test report
- ·Microbiological test report
- ·Non-GMO / allergen statement
- ·Country-of-origin documentation
- ·Packing list & commercial invoice
Certificate availability should be confirmed with our sales team before ordering.
Sample Certificate of Analysis
PathGene Biotech Co., Ltd.
南京派琪生物科技有限公司
CERTIFICATE OF ANALYSIS
Layout example — not an issued batch record
Product Name
NMN
CAS No.
1094-61-7
Batch No.
PG-SAMPLE-000000
Packaging
Issued upon order confirmation
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white crystalline powder | Conforms, white to off-white powder |
| Odor | Odorless or faint characteristic odor | Conforms |
| Assay (HPLC) | ≥99.5% | 99.6% |
| Identification (MS/NMR, formula confirmation) | Conforms to C11H15N2O8P | Conforms |
| Loss on Drying | ≤1.0% | 0.4% |
| pH (1% aqueous solution) | 6.0-7.5 | 6.8 |
| Residue on Ignition / Sulfated Ash | ≤0.5% | 0.2% |
| Heavy Metals - Lead (Pb) | ≤2 ppm | <1 ppm |
| Heavy Metals - Mercury (Hg) | ≤0.1 ppm | <0.05 ppm |
| Heavy Metals - Cadmium (Cd) | ≤1 ppm | <0.5 ppm |
| Heavy Metals - Arsenic (As) | ≤1 ppm | <0.5 ppm |
| Total Plate Count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mold | ≤100 CFU/g | <10 CFU/g |
| E. coli / Salmonella | Negative/25g | Negative |
Conclusion: Conforms to internal quality specifications
The COA issued with your order will carry the actual batch number, manufacture/test dates, and QC signature.
Related Products
NRHM
Nicotinamide Riboside Hydrogen Malate
Interested in NMN?
Our R&D team will respond to your inquiry or sample request within 24 hours.
