NMN
Bulk NMN powder for NAD+ precursor and healthy-aging formulation development
PathGene supplies bulk NMN powder (CAS 1094-61-7) with a specified purity of ≥99.5% for capsule, tablet and powder-blend development. Request a batch COA, sample, packaging details and lead time. NAD+ ingredients
Confirm beta-form identity, assay basis and moisture controls.
Key Specifications
| Product Positioning | Bulk NMN powder for NAD+ precursor and healthy-aging formulation development |
| Application Scenarios | capsule and tablet formulation · NAD+ pathway research · water-soluble powder development |
| CAS Number | 1094-61-7 |
| Purity | ≥99.5% |
| Molecular Formula | C₁₁H₁₅N₂O₈P |
| Molecular Weight | 334.22 g/mol |
| Appearance | White to off-white crystalline powder |
| Solubility | Freely soluble in water |
| Storage | Sealed packaging, stored at cool, dry and away from light |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
PathGene is an NMN manufacturer and bulk ingredient supplier in China, offering beta-NMN raw material (CAS 1094-61-7) for wholesale sourcing and formulation development. Free samples, batch COAs and third-party test reports are available for buyer evaluation. β-Nicotinamide mononucleotide (NMN, CAS 1094-61-7, C11H15N2O8P, MW 334.22 g/mol) is a naturally occurring nucleotide formed from nicotinamide, ribose, and a phosphate group. It occurs in trace amounts in foods such as broccoli, edamame, cabbage, and cucumber, and serves as a direct biosynthetic precursor of NAD+ (nicotinamide adenine dinucleotide), a coenzyme central to cellular energy metabolism and redox signaling. Because natural abundance is far too low for commercial extraction, bulk NMN used in supplements, cosmetic actives, and pharmaceutical-grade materials is manufactured through enzymatic/biocatalytic conversion: engineered microbial enzymes (e.g., nicotinamide riboside kinase or nicotinamide phosphoribosyltransferase), paired with an ATP-regeneration system, convert precursor substrates into NMN, which is then purified and crystallized to achieve high-purity powder form. For private label and OEM projects, contact PathGene about capsule or tablet development and packaging. Finished-product minimum orders and schedules are quoted separately from bulk raw material orders.
Purity Tested up to 99.9%
NMN purity reaches 99.9% in batch testing and third-party testing. Request the corresponding batch COA and independent report to review the result and test method.
Immobilized Enzyme Production, No Chloride Contamination
Produced via a controlled immobilized-enzyme biocatalytic process rather than chlorinated chemical routes, minimizing chloride ion residues and other process-related impurities.
Consistent Crystalline Powder
Uniform white to off-white crystalline powder with controlled particle size, freely soluble in water for easy handling in downstream formulation.
Full Contaminant & Microbial Screening
Every batch is screened for heavy metals (Pb, Hg, Cd, As), residual solvents, and microbial limits (total plate count, yeast/mold, E. coli, Salmonella) before release.
Flexible Bulk & OEM Supply
Available in flexible bulk quantities with OEM/private-label support, plus formulation guidance for capsules, sublingual tablets, sachets, and topical serums.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGNMN-260522
Test date
2026-05-23
Specification
Q/PGNMN-2025
Pack size
25 kg/drum
Storage
Sealed packaging, stored at cool, dry and away from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white powder | White powder |
| Identification | HPLC main peak retention time consistent with reference product | Complies |
| Purity | ≥99.0% | 99.9% |
| Assay (calculated on dry basis) | ≥99.0% | 100.0% |
| Loss on Drying | ≤2.0% | 0.19% |
| pH | 3.0–4.0 | 3.67 |
| Ethanol Residue | ≤500 ppm | Complies |
| Lead (Pb) | ≤0.1 ppm | Complies |
| Mercury (Hg) | ≤0.1 ppm | Complies |
| Cadmium (Cd) | ≤0.2 ppm | Complies |
| Arsenic (As) | ≤0.1 ppm | Complies |
| Total Microbial Count | ≤500 CFU/g | <10 CFU/g |
| Coliforms | ≤0.92 MPN/g | <0.3 MPN/g |
| Mold and Yeast | ≤50 CFU/g | <10 CFU/g |
| Staphylococcus aureus | 0/25 g | Not detected |
| Salmonella | 0/25 g | Not detected |
| Bulk Density | — | 0.60 g/mL |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
NAD⁺ turnover generates nicotinamide, and NNMT-dependent methylation of nicotinamide uses the SAM methyl-donor system. TMG can support homocysteine remethylation through the BHMT pathway, making it a scientifically plausible methylation-support direction rather than a proven requirement for NMN users.
Evidence: Biochemical rationale; no direct human NMN+TMG efficacy trial identified.Source
NMN supports NAD⁺ availability, while PQQ has been studied for redox signaling and SIRT1/PGC-1α-linked mitochondrial biogenesis. This supports a mitochondrial-energy and redox-resilience formulation concept, subject to dose and compatibility testing.
Evidence: Mechanism-level and cell-study rationale; direct NMN+PQQ human evidence remains limited.Source
NMN provides a precursor for NAD⁺ metabolism, while resveratrol is used in AMPK/SIRT1 and redox-signaling research. In a mouse distribution study, the combination increased NAD⁺ levels in heart and skeletal muscle versus NMN alone, supporting further formulation research.
Evidence: Mouse study; not a clinical proof of synergy or a finished-product efficacy claim.Source
Literature-Supported Research Directions
NMN is a direct nicotinamide nucleotide intermediate in NAD⁺ biosynthesis. In preclinical models, oral NMN can be utilized for NAD⁺ synthesis in peripheral tissues, supporting research into NAD⁺-dependent enzymes, DNA-repair signaling and mitochondrial homeostasis.
Citation: Mills et al., Cell Metabolism (2016), NMN as a key NAD⁺ intermediate in diet- and age-induced diabetes models.View source
In a 10-week randomized, placebo-controlled trial in postmenopausal women with prediabetes who were overweight or obese, NMN supplementation increased skeletal-muscle insulin sensitivity and insulin signaling. This supports further research into NAD⁺ turnover, muscle remodeling and metabolic formulation strategies.
Citation: Yoshino et al., Science 372 (2021), 1224–1229.View source
In aged-mouse studies, NMN supplementation was associated with improved age-related endothelial dysfunction and reduced measures of large-artery stiffness. These findings support continued investigation of NAD⁺-SIRT1 signaling and vascular-aging models.
Citation: Das et al., npj Aging and Mechanisms of Disease (2018), vascular dysfunction and oxidative stress in aged mice.View source
NMN has been studied in amyloid-related neuronal injury and Alzheimer’s disease models, where researchers observed changes in NAD⁺/ATP, oxidative stress and cognitive-test outcomes. The evidence remains preclinical and is best presented as a neurobiology research direction.
Citation: Wang et al., Brain Research (2016), NMN in amyloid-β oligomer-induced neuronal injury and cognitive-impairment models.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
1 kg
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Associated Patents
ZL 2022 1 0234567.X
Granted Chinese Invention Patent — core synthesis process protected by IP, ensuring supply stability and proprietary process exclusivity.
+ PathGene holds 12 core invention patents in total
Biocatalyst Fermentation
An engineered microbial strain expressing the target enzyme (e.g., nicotinamide riboside kinase or nicotinamide phosphoribosyltransferase) is cultivated by fermentation to produce the biocatalyst in a controlled bioreactor.
Enzyme Extraction & Immobilization
The enzyme is extracted, purified, and immobilized onto a solid carrier, enabling reuse across reaction cycles and reducing ionic and chemical residues compared with solution-phase chemical synthesis.
Substrate & Cofactor Preparation
Precursor substrate (nicotinamide riboside, or nicotinamide with 5-phosphoribosyl-1-pyrophosphate) is prepared alongside an ATP-regeneration system to sustain the phosphorylation/condensation reaction at scale.
Enzymatic Bioconversion
Under controlled temperature and pH, the immobilized enzyme catalyzes conversion of the substrate into NMN within a stirred-tank or packed-bed bioreactor, monitored for conversion yield in real time.
Biomass & Enzyme Carrier Removal
Reaction broth is clarified by filtration/centrifugation to separate the immobilized enzyme carrier and residual biomass from the product stream.
Purification & Ion Removal
The crude NMN solution undergoes chromatographic and/or ion-exchange purification to remove salts, chloride ions, and byproducts, concentrating the target compound.
Crystallization, Drying & Milling
Controlled crystallization yields high-purity NMN crystals, which are then vacuum-dried and milled to a consistent particle size for the finished powder.
Quality Control & Packaging
Finished batches are tested for assay (HPLC), heavy metals, and microbial limits, then packed under nitrogen-flushed, moisture-protected conditions with a batch COA.
NMN purity is tested by HPLC. Batch testing and third-party testing can reach 99.9%; consult the corresponding report for the lot and method. Product acceptance specifications and measured batch results are shown separately.
NMN is freely soluble in water, which supports its use across a range of delivery formats including oral capsules and tablets, sublingual formats for faster mucosal absorption, effervescent or powder sachets, and, for pharmaceutical-grade material, sterile injectable solutions. For topical/cosmetic applications, NMN is typically incorporated at 0.1-0.5% in aqueous-phase serums or emulsions; formulators should evaluate pH stability and packaging light/oxygen protection, as NMN solutions may be sensitive to prolonged heat and light exposure.
Each batch is tested by HPLC against a reference standard, with a Certificate of Analysis (COA) issued per batch. Buyers are welcome to request the COA for the specific lot before purchase, and third-party verification is supported.
Our NMN is produced via an immobilized-enzyme biocatalytic process, avoiding chlorinated chemical routes and their associated chloride ion residues. This enzymatic approach supports high purity and consistent batch-to-batch quality.
Yes, NMN is freely soluble in water, making it suitable for capsules, sublingual tablets, powder sachets, and, at pharmaceutical grade, injectable solutions. It can also be incorporated into aqueous-phase cosmetic serums at 0.1-0.5%.
Yes, samples are available for qualified B2B buyers to evaluate purity, appearance, and solubility ahead of a bulk order. Please contact our sales team to arrange sample shipment and documentation.
Yes, buyers are free to submit samples to third-party laboratories of their choice for independent verification of purity, heavy metals, and microbial limits. We are happy to cooperate with recognized testing bodies.
Yes, we support OEM/private-label collaboration, including formulation guidance for capsules, sublingual tablets, sachets, and topical serums, in addition to supplying bulk raw material.
NMN is typically packed in moisture-protected, nitrogen-flushed containers (e.g., 1 kg, 5 kg, or 25 kg drums), with custom packaging available on request. MOQ and pricing depend on quantity and grade (food/cosmetic vs. pharmaceutical); please contact us directly for a formal quotation.
Yes. NMN purity can reach 99.9% in third-party testing. Request the corresponding report and batch COA when qualifying the ingredient; the results relate to the tested material.
Send your required quantity, destination and intended application. The minimum order is 1 kg, with 1 kg, 5 kg and 25 kg packaging options. Standard lead time is 3–5 business days, subject to order confirmation. Free samples are available for qualified B2B buyers.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Independent test record · Available by product/batch
Technical Resources
Selling NMN, NR or NAD+ in Australia? Compare TGA listing conditions, NRC food-use permissions and the questions to resolve before sourcing ingredients.
A practical guide to evaluating ≥99.5% NMN, batch-specific COAs, analytical methods, and supplier documentation before bulk purchase.
NMN and NR haven't cleared China's domestic food or pharmaceutical approval process, so they're classified and supplied as industrial/chemical raw materials for research, export, and other non-food, non-pharma uses. Here's what that status actually means for a buyer, and why a supplier stating it plainly is a good sign, not a red flag.
Related Products
NAD+ Powder (β-Nicotinamide Adenine Dinucleotide)
Nicotinamide Riboside Chloride Powder (NR/NRC)
NRHM Powder (Nicotinamide Riboside Hydrogen Malate)
NMNH Powder (Reduced Nicotinamide Mononucleotide)
Interested in NMN?
Our R&D team will respond to your inquiry or sample request within 24 hours.
Scan to add WeChat
Alex Huang · Mon–Fri 9am–6pm CST
