GSH
CAS 70-18-8
Purity≥98.0%
Reduced glutathione for antioxidant and personal-care formulations
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore nutrition & functional ingredients.
Confirm reduced/oxidized ratio and stability in solution.
Key Specifications
| Product Positioning | Reduced glutathione for antioxidant and personal-care formulations |
| Application Scenarios | antioxidant beverage formulas · topical serum prototypes · redox-biology research |
| CAS Number | 70-18-8 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₀H₁₇N₃O₆S |
| Molecular Weight | 307.32 g/mol |
| Appearance | White crystalline powder |
| Solubility | Freely soluble in water |
| Storage | 2–8°C, inert atmosphere |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Glutathione (reduced), abbreviated GSH, is a low-molecular-weight tripeptide composed of L-glutamic acid, L-cysteine, and glycine, linked through an unusual γ-carboxyl amide bond (CAS 70-18-8; molecular formula C10H17N3O6S; MW 307.32 g/mol). It occurs naturally in virtually all living cells, including plants, animals, fungi, and many bacteria, where it is synthesized intracellularly in two ATP-dependent enzymatic steps and functions as the principal intracellular thiol-based antioxidant and detoxification cofactor. Commercially, bulk GSH is produced almost exclusively by microbial fermentation, typically using high-yield, non-GMO Saccharomyces cerevisiae strains grown on sugar/molasses-based media, followed by cell disruption, extraction, chromatographic purification, and crystallization to obtain the white crystalline powder supplied to the pharmaceutical, dietary supplement, and cosmetic industries.
High-Purity, Pharma-Grade Assay
Each batch is assayed by HPLC to confirm ≥98.0% purity, consistent with USP monograph requirements for reduced glutathione.
Controlled Fermentation & Traceable Raw Materials
Produced via monitored yeast fermentation with documented strain, media, and process parameters, enabling raw-material traceability from seed culture to finished powder.
Consistent White Crystalline Powder
Uniform white to off-white crystalline powder with consistent particle size and no visible impurities, ensuring stable dissolution and handling across batches.
Comprehensive Contaminant & Microbial Testing
Every lot is screened for heavy metals (Pb, Hg, Cd, As) and microbial limits, with a Certificate of Analysis available on request.
Flexible Bulk & OEM Supply
Available in bulk quantities with customizable packaging, particle size, and documentation to support dietary supplement, cosmetic, and pharmaceutical OEM/ODM programs.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGGSH-260420
Test date
2026-04-21
Specification
USP43
Pack size
25kg/carton
Storage
2–8°C, inert atmosphere
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white crystalline powder | Conforms, white crystalline powder |
| Odor | Odorless | Odorless |
| Assay (HPLC) | ≥98.0% | 99.1% |
| pH (1% aqueous solution) | 2.5–3.5 | 3.1 |
| Specific Optical Rotation | -15.5° to -17.5° (c=2, water) | -16.7° |
| Loss on Drying | ≤1.0% | 0.35% |
| Residue on Ignition | ≤0.2% | 0.06% |
| Lead (Pb) | ≤2 mg/kg | <1 mg/kg |
| Heavy Metals (as Pb, incl. Hg/Cd/As) | ≤10 mg/kg | <5 mg/kg |
| Arsenic (As) | ≤2 mg/kg | <1 mg/kg |
| Particle Size | 100% through 80 mesh | Conforms |
| Total Plate Count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mold | ≤100 CFU/g | <10 CFU/g |
| E. coli / Salmonella | Negative/25 g | Negative |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Dietary supplements
Cosmetics
Pharmaceutical and API development
Screen around glutathione redox cycling and the vitamin-C antioxidant system, with emphasis on solubility, stability and storage conditions.
Evidence: Nutritional and biochemical rationale; not proof of combination clinical efficacy.Source
Literature-Supported Research Directions
Glutathione is a major intracellular reductive thiol involved in reactive-oxygen-species control, redox cycling and cellular stress responses. Research directions include antioxidant, inflammatory-signaling and cytoprotection studies, while oral outcomes depend on dosage form, dose and bioavailability.
Citation: Richie et al., European Journal of Nutrition (2015), six-month randomized trial of oral glutathione and body stores.View source
Glutathione can support research into oxidative-stress biomarkers, skin redox balance and pigment-related pathways. Findings are not uniform across studies and do not replace clinical validation of a finished product.
Citation: Allen et al., Journal of Alternative and Complementary Medicine (2011), four-week oral study in healthy adults with no significant oxidative-stress biomarker change.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
1 kg
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Insulated Box + Carton
For products requiring temperature-controlled transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
USP
US Pharmacopoeia
Strain Preparation & Seed Culture
A high-GSH-yielding, non-GMO Saccharomyces cerevisiae strain is activated and expanded through seed culture stages to generate a robust inoculum for the main fermenter.
Aerobic Fed-Batch Fermentation
The seed culture is transferred to stainless-steel bioreactors containing a glucose/molasses and corn-steep-liquor-based medium, with controlled aeration, pH, temperature, and sugar/ethanol feeding to maximize intracellular GSH accumulation.
Biomass Harvesting
At the end of fermentation, yeast cells are separated from the fermentation broth by centrifugation or membrane filtration to obtain concentrated wet biomass.
Cell Disruption & GSH Release
Harvested cells are lysed through mechanical disruption, autolysis, or enzymatic cell-wall breakdown to release intracellular glutathione into solution.
Clarification & Impurity Removal
Cell debris, proteins, and nucleic acids are removed by centrifugation, ultrafiltration, and/or activated-carbon treatment to yield a clarified GSH-rich extract.
Chromatographic Purification
The clarified extract is purified using ion-exchange resin chromatography to selectively bind and elute glutathione while removing residual amino acids, peptides, and salts.
Concentration & Crystallization
The purified eluate is concentrated under vacuum and cooled to induce crystallization, yielding high-purity glutathione crystals.
Drying, Milling & Packaging
Crystals are separated, vacuum- or fluid-bed dried, milled to the target particle size, and packaged under controlled conditions to protect against oxidation and moisture uptake.
Purity is determined by high-performance liquid chromatography (HPLC) with UV detection, referencing USP/EP-type reduced-glutathione monograph methods and a validated reference standard to compare peak area against the labeled assay. Buyers should request the current Certificate of Analysis (COA) for the specific batch, confirm the HPLC method and reference standard used, and verify results independently through a qualified third-party laboratory before large-scale procurement or regulatory filing.
Reduced glutathione is freely soluble in water, forming clear, colorless-to-faint solutions, but its free thiol group is prone to oxidation to the disulfide form (GSSG) upon prolonged exposure to air, light, heat, or trace metal ions. For liquid formulations (oral solutions, injectables, or cosmetic serums), buyers are advised to process under inert atmosphere or low-oxygen conditions, use appropriate chelating agents and antioxidant stabilizers, maintain a mildly acidic pH, and store finished products refrigerated and protected from light to preserve the reduced (active) form throughout shelf life.
Purity is verified by HPLC assay against a certified reference standard, and each shipment is accompanied by a Certificate of Analysis (COA) showing the specific batch's assay result along with related-substance and heavy-metal data.
Our glutathione is produced by controlled microbial fermentation using a high-yield yeast strain, followed by extraction, chromatographic purification, and crystallization — the standard industrial route for pharmaceutical- and food-grade GSH.
Yes, it is freely soluble in water. Because the reduced thiol form can oxidize on exposure to air, heat, or light, we recommend low-oxygen processing, suitable stabilizers, and cool, dark storage for finished formulations.
Yes, small samples are available for evaluation and quality verification prior to bulk purchase; please contact our sales team with your intended application and required quantity.
Yes, we support and encourage third-party testing; buyers are welcome to submit samples to an independent laboratory of their choice, and we can coordinate additional testing on request.
Yes, we offer OEM/ODM support including customized packaging, labeling, particle size, and formulation-ready blends for dietary supplement, cosmetic, and pharmaceutical customers.
Standard packaging includes 1 kg, 5 kg, and 25 kg fiber drums or bags with double-layer food/pharma-grade liners; MOQ and pricing depend on order volume and specification, so please contact us for a formal quotation.
This product is manufactured to meet USP monograph requirements under our internal quality management system, with batch-specific documentation available to support regulatory submissions.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
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Alex Huang · Mon–Fri 9am–6pm CST
