UA
Urolithin A
Key Specifications
| CAS Number | 1143-70-0 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₃H₈O₄ |
| Molecular Weight | 228.20 g/mol |
| Appearance | Light yellow to yellow powder |
| Solubility | Slightly soluble in water; soluble in DMSO |
| Storage | Room temperature, protect from light |
| Shelf Life | 24 months |
CAS 1143-70-0
What Is UA?
Urolithin A (UA, CAS 1143-70-0) is a benzo-coumarin (dibenzo-alpha-pyranone) with molecular formula C13H8O4 and molecular weight 228.20 g/mol. In nature it arises as a gut-microbiota metabolite formed from ellagitannins and ellagic acid found in pomegranates, walnuts, and various berries, but only a subset of individuals (so-called "urolithin metabotype A") convert these precursors efficiently, and natural yields are low and highly inconsistent. Because of this variability, commercial bulk material is not extracted from plants or produced by in-body fermentation; it is instead manufactured through controlled organic synthesis — typically a copper-catalyzed coupling of simple hydroxylated aromatic building blocks followed by cyclization, acidification, and recrystallization — yielding a consistent, high-purity powder suitable for research and nutraceutical formulation.
Other Names
Key Features
High, Consistent Purity
Each batch is manufactured to ≥98.0% purity by HPLC, with certificate-of-analysis traceability so buyers can confirm identity and assay before every shipment.
Controlled Synthetic Production
Produced via a defined multi-step organic synthesis route rather than variable microbial bioconversion, giving predictable impurity profiles and reliable batch-to-batch reproducibility.
Stable Powder Form
Supplied as a light yellow to yellow, free-flowing powder that is easy to weigh, blend, and process in downstream formulation lines.
Full Contaminant & Microbial Testing
Every batch is screened for heavy metals (Pb, Hg, Cd, As), residual solvents, and microbial limits (total plate count, yeast/mold, E. coli, Salmonella) to support food, supplement, and research-grade use.
Flexible Bulk & OEM Supply
Available from gram-scale research quantities to multi-kilogram bulk orders, with OEM/private-label packaging and formulation support from an ISO9001-certified manufacturer.
| Molecular Formula | C₁₃H₈O₄ |
| Molecular Weight | 228.20 g/mol |
| Appearance | Light yellow to yellow powder |
| Solubility | Slightly soluble in water; soluble in DMSO |
| Storage Condition | Room temperature, protect from light |
| Shelf Life | 24 months |
| Grade 1 | Supplement Grade · ≥98.0% · COA |
End-Product Applications
Mechanism & Benefits
Activates cellular autophagy and mitophagy. Protects mitochondrial function, delays muscle aging and improves exercise endurance.
Packaging Options
100 g 500 g 1 kg
Lead Time
7–10 business days
Minimum Order
100 g
Custom Packaging
Custom packaging (foil bags, HDPE drums), GMP labeling, and export documentation are available. Contact us for specifics.Certifications
ISO
ISO
ISO9001
ISO 9001
Manufacturing Process
Precursor Sourcing & Incoming QC
Hydroxylated aromatic starting materials (a bromo-hydroxybenzoic acid derivative and resorcinol) are sourced and verified by identity and purity testing before release to production.
Copper-Catalyzed Aryl Coupling
The aromatic building blocks undergo a copper-catalyzed coupling reaction under basic (aqueous sodium hydroxide) conditions to form the biaryl intermediate.
Base-Mediated Cyclization / Lactonization
The biaryl intermediate is cyclized under controlled temperature and pH to close the lactone ring and build the characteristic dibenzo-alpha-pyranone (benzo-coumarin) core of urolithin A.
Acidification & Crude Isolation
The resulting sodium salt is protonated by controlled acidification, precipitating crude urolithin A, which is filtered and washed to remove residual inorganic salts.
Purification by Recrystallization
Crude material is purified by recrystallization/trituration (e.g., in an acetic acid-based solvent system) to remove regioisomeric byproducts and trace catalyst residues.
Drying, Milling & Particle Size Control
The purified solid is dried under vacuum, then milled and sieved to achieve a uniform, free-flowing powder within target particle-size specifications.
Final Release Testing & Packaging
Each batch undergoes HPLC assay, identification, heavy metal, and microbial testing before being packaged under moisture-protected, light-controlled conditions for shipment.
Quality Specifications
| Test Item | Specification | Result |
|---|---|---|
| Appearance | Light yellow to yellow powder | Conforms, light yellow powder |
| Odor | Odorless or characteristic | Odorless |
| Identification (HPLC retention time / UV spectrum) | Consistent with reference standard | Conforms |
| Assay (HPLC) | ≥98.0% | 98.6% |
| Melting point | 235-238°C | 236.5°C |
| Loss on drying | ≤0.5% | 0.3% |
| Particle size (through mesh) | ≥95% through 80 mesh | 98% through 80 mesh |
| Lead (Pb) | ≤2 mg/kg | <1 mg/kg |
| Arsenic (As) | ≤2 mg/kg | <1 mg/kg |
| Mercury (Hg) | ≤1 mg/kg | <0.1 mg/kg |
| Cadmium (Cd) | ≤1 mg/kg | <0.1 mg/kg |
| Total plate count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & mold | ≤100 CFU/g | <10 CFU/g |
| Pathogens (E. coli / Salmonella) | Negative/25 g | Negative |
Purity & Assay Method
Purity is determined by reversed-phase HPLC with UV detection, comparing the sample against a certified urolithin A reference standard under a validated method (typical detection around 254-360 nm). Because urolithin A has structurally similar regioisomers and synthesis-related byproducts, buyers should request the batch-specific HPLC chromatogram, the reference standard used, and the full certificate of analysis, and are encouraged to confirm results with independent third-party testing before large-scale procurement.
Solubility & Formulation
Urolithin A is slightly soluble in water but readily dissolves in DMSO and other polar organic solvents such as ethanol or methanol, which is convenient for in vitro research use but limits direct aqueous formulation. For supplement and functional-food applications, common approaches to improve dispersibility and bioavailability include particle-size reduction (micronization), complexation with cyclodextrins, solid dispersion technologies, and lipid-based or self-emulsifying delivery systems. DMSO stock solutions are appropriate for cell-based assays but are not suitable for oral products; formulators should select solvents and excipients compatible with their intended delivery format and regulatory requirements.
Available Product Forms
Bulk UA Powder
High-purity raw powder for supplement factories, research organizations, ingredient distributors, and contract manufacturers.
UA Capsules
Custom capsule strength, shell material, bottle count, excipients, and label design for private-label brands.
UA Tablets
Tablet formulation, granulation, compression, coating, bottle packaging, and custom labeling support.
UA Powder Blends
UA can be blended with complementary actives (antioxidants, other longevity ingredients, vitamins, minerals) per customer formula.
How can we verify the purity and specifications of a specific batch before ordering?+
Every batch ships with a certificate of analysis covering HPLC assay, identification, heavy metals, and microbial testing. We can provide the batch-specific CoA and chromatogram on request prior to order confirmation.
Is your Urolithin A extracted from pomegranate or produced by fermentation?+
No. Because natural conversion of ellagitannins to urolithin A by gut bacteria varies greatly between individuals and yields are low, our material is produced through a controlled multi-step organic synthesis, which gives consistent identity, purity, and supply reliability suitable for commercial use.
What is the solubility of Urolithin A and how should it be handled in formulation?+
It is slightly soluble in water and soluble in DMSO. For water-based or oral formulations, techniques such as micronization, cyclodextrin complexation, or lipid-based delivery systems are commonly used to improve dispersibility; DMSO is best reserved for research/cell-based work.
Can we request a sample before placing a bulk order?+
Yes, small research or evaluation samples are available on request so you can independently verify appearance, solubility, and purity before committing to a bulk order.
Do you support independent third-party testing of your material?+
Yes. In addition to our internal CoA, we welcome buyers to send samples to an independent laboratory of their choice for third-party verification of purity, heavy metals, and microbial limits.
Do you offer OEM or private-label services?+
Yes, we support OEM/private-label packaging, custom specifications, and formulation guidance for customers developing supplement or functional-food finished products.
What packaging options and minimum order quantities are available?+
Standard packaging includes foil bags and fiber/plastic drums in various sizes (e.g., 25g/100g for research, 1kg/5kg/25kg for bulk). MOQ and lead times are flexible and depend on required purity grade and packaging format — contact us for a formal quotation.
Why Choose PathGene
- Direct China manufacturer supply — factory pricing, no middleman
- Batch-specific COA & full traceability on every shipment
- In-house R&D + synthetic biology / enzymatic production platform
- Free sample for qualified B2B buyers before commercial order
- Flexible MOQ — from lab-scale trial to ton-scale commercial supply
- One-stop OEM/private-label support for finished dosage forms
- Worldwide shipping by courier, air freight, and sea freight
OEM & Private-Label Services
- ·Custom capsule manufacturing
- ·Custom tablet manufacturing
- ·Powder blending & custom formulation
- ·Private-label bottles, pouches & labels
- ·Small trial orders
- ·Bulk commercial production
- ·Export documentation
- ·Third-party laboratory testing
Documents Available
- ·Certificate of Analysis (COA)
- ·Product specification sheet
- ·Material Safety Data Sheet (MSDS)
- ·Manufacturing flow chart
- ·HPLC test report
- ·Heavy-metal test report
- ·Microbiological test report
- ·Non-GMO / allergen statement
- ·Country-of-origin documentation
- ·Packing list & commercial invoice
Certificate availability should be confirmed with our sales team before ordering.
Sample Certificate of Analysis
PathGene Biotech Co., Ltd.
南京派琪生物科技有限公司
CERTIFICATE OF ANALYSIS
Layout example — not an issued batch record
Product Name
UA
CAS No.
1143-70-0
Batch No.
PG-SAMPLE-000000
Packaging
Issued upon order confirmation
| Test Item | Specification | Result |
|---|---|---|
| Appearance | Light yellow to yellow powder | Conforms, light yellow powder |
| Odor | Odorless or characteristic | Odorless |
| Identification (HPLC retention time / UV spectrum) | Consistent with reference standard | Conforms |
| Assay (HPLC) | ≥98.0% | 98.6% |
| Melting point | 235-238°C | 236.5°C |
| Loss on drying | ≤0.5% | 0.3% |
| Particle size (through mesh) | ≥95% through 80 mesh | 98% through 80 mesh |
| Lead (Pb) | ≤2 mg/kg | <1 mg/kg |
| Arsenic (As) | ≤2 mg/kg | <1 mg/kg |
| Mercury (Hg) | ≤1 mg/kg | <0.1 mg/kg |
| Cadmium (Cd) | ≤1 mg/kg | <0.1 mg/kg |
| Total plate count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & mold | ≤100 CFU/g | <10 CFU/g |
| Pathogens (E. coli / Salmonella) | Negative/25 g | Negative |
Conclusion: Conforms to internal quality specifications
The COA issued with your order will carry the actual batch number, manufacture/test dates, and QC signature.
Related Products
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Pyrroloquinoline Quinone Disodium Salt
Interested in UA?
Our R&D team will respond to your inquiry or sample request within 24 hours.
