UA
CAS 1143-70-0
Purity≥99.0%
Urolithin A material for mitochondrial and healthy-aging research
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore healthy-aging ingredients.
Confirm chemical form, particle handling and current-lot COA.
Key Specifications
| Product Positioning | Urolithin A material for mitochondrial and healthy-aging research |
| Application Scenarios | mitochondrial research · healthy-aging nutrition formulas · solid-dose screening |
| CAS Number | 1143-70-0 |
| Purity | ≥99.0% |
| Molecular Formula | C₁₃H₈O₄ |
| Molecular Weight | 228.20 g/mol |
| Appearance | Light yellow to yellow powder |
| Solubility | Slightly soluble in water; soluble in DMSO |
| Storage | Room temperature, protect from light |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Urolithin A (UA, CAS 1143-70-0) is a benzo-coumarin (dibenzo-alpha-pyranone) with molecular formula C13H8O4 and molecular weight 228.20 g/mol. In nature it arises as a gut-microbiota metabolite formed from ellagitannins and ellagic acid found in pomegranates, walnuts, and various berries, but only a subset of individuals (so-called "urolithin metabotype A") convert these precursors efficiently, and natural yields are low and highly inconsistent. Because of this variability, commercial bulk material is not extracted from plants or produced by in-body fermentation; it is instead manufactured through controlled organic synthesis — typically a copper-catalyzed coupling of simple hydroxylated aromatic building blocks followed by cyclization, acidification, and recrystallization — yielding a consistent, high-purity powder suitable for research and nutraceutical formulation.
≥99% Assayed Purity
Each batch is manufactured to ≥99% purity by HPLC, with certificate-of-analysis traceability so buyers can confirm identity and assay before every shipment.
Controlled Synthetic Production
Produced via a defined multi-step organic synthesis route rather than variable microbial bioconversion, giving predictable impurity profiles and reliable batch-to-batch reproducibility.
Stable Powder Form
Supplied as a light yellow to yellow, free-flowing powder that is easy to weigh, blend, and process in downstream formulation lines.
Full Contaminant & Microbial Testing
Every batch is screened for heavy metals (Pb, Hg, Cd, As), residual solvents, and microbial limits (total plate count, yeast/mold, E. coli, Salmonella) to support food, supplement, and research-grade use.
Flexible Bulk & OEM Supply
Available from gram-scale research quantities to multi-kilogram bulk orders, with OEM/private-label packaging and formulation support, plus full batch documentation.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGUA-260112
Test date
2026-01-13
Specification
In-house
Pack size
25 kg/carton
Storage
Room temperature, protect from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to yellow powder | Yellow powder |
| Identification | IR spectrum and HPLC retention time conform to reference | Complies |
| Purity | ≥98% | 99.7% |
| Assay (dry basis) | 98.0%–102% | 99.6% |
| Water | ≤3.0% | 0.3% |
| Residue on ignition | ≤0.5% | 0.25% |
| Lead (Pb) | ≤0.5 ppm | Complies |
| Mercury (Hg) | ≤0.5 ppm | Complies |
| Cadmium (Cd) | ≤0.5 ppm | Complies |
| Arsenic (As) | ≤0.5 ppm | Complies |
| Total plate count | ≤1000 CFU/g | Complies |
| Yeast and mold | ≤100 CFU/g | Complies |
| Coliforms | Not detected | Complies |
| Staphylococcus aureus | Not detected | Complies |
| Salmonella | Not detected | Complies |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Softgels
Gummies
Stick-pack powders
Protein powders
Skincare creams
Facial serums
This format combines a mitochondrial-health ingredient with a familiar sports-nutrition matrix and is already represented by commercial Urolithin A protein-powder products.
Evidence: Commercial-format support only. The cited randomized trial evaluated Urolithin A itself and does not establish additional efficacy from protein co-formulation.Source
Literature-Supported Research Directions
Urolithin A is a gut-microbiota-derived postbiotic studied as a mitophagy activator. In a first-in-human study, repeated intake modulated plasma acylcarnitines and skeletal-muscle mitochondrial gene expression in older adults.
Citation: Andreux et al., Nature Metabolism (2019): first-in-human urolithin A trial.View source
Randomized trials in middle-aged and older adults reported changes in muscle endurance and mitochondrial-related biomarkers, while some primary endpoints such as maximal ATP production were not significantly different. These findings support formulation and exercise-nutrition research.
Citation: Liu et al., JAMA Network Open (2022): randomized clinical trial in older adults.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
100 g
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Precursor Sourcing & Incoming QC
Hydroxylated aromatic starting materials (a bromo-hydroxybenzoic acid derivative and resorcinol) are sourced and verified by identity and purity testing before release to production.
Copper-Catalyzed Aryl Coupling
The aromatic building blocks undergo a copper-catalyzed coupling reaction under basic (aqueous sodium hydroxide) conditions to form the biaryl intermediate.
Base-Mediated Cyclization / Lactonization
The biaryl intermediate is cyclized under controlled temperature and pH to close the lactone ring and build the characteristic dibenzo-alpha-pyranone (benzo-coumarin) core of urolithin A.
Acidification & Crude Isolation
The resulting sodium salt is protonated by controlled acidification, precipitating crude urolithin A, which is filtered and washed to remove residual inorganic salts.
Purification by Recrystallization
Crude material is purified by recrystallization/trituration (e.g., in an acetic acid-based solvent system) to remove regioisomeric byproducts and trace catalyst residues.
Drying, Milling & Particle Size Control
The purified solid is dried under vacuum, then milled and sieved to achieve a uniform, free-flowing powder within target particle-size specifications.
Final Release Testing & Packaging
Each batch undergoes HPLC assay, identification, heavy metal, and microbial testing before being packaged under moisture-protected, light-controlled conditions for shipment.
Purity is determined by reversed-phase HPLC with UV detection, comparing the sample against a certified urolithin A reference standard under a validated method (typical detection around 254-360 nm). Because urolithin A has structurally similar regioisomers and synthesis-related byproducts, buyers should request the batch-specific HPLC chromatogram, the reference standard used, and the full certificate of analysis, and are encouraged to confirm results with independent third-party testing before large-scale procurement.
Urolithin A is slightly soluble in water but readily dissolves in DMSO and other polar organic solvents such as ethanol or methanol, which is convenient for in vitro research use but limits direct aqueous formulation. For supplement and functional-food applications, common approaches to improve dispersibility and bioavailability include particle-size reduction (micronization), complexation with cyclodextrins, solid dispersion technologies, and lipid-based or self-emulsifying delivery systems. DMSO stock solutions are appropriate for cell-based assays but are not suitable for oral products; formulators should select solvents and excipients compatible with their intended delivery format and regulatory requirements.
Every batch ships with a certificate of analysis covering HPLC assay, identification, heavy metals, and microbial testing. We can provide the batch-specific CoA and chromatogram on request prior to order confirmation.
No. Because natural conversion of ellagitannins to urolithin A by gut bacteria varies greatly between individuals and yields are low, our material is produced through a controlled multi-step organic synthesis, which gives consistent identity, purity, and supply reliability suitable for commercial use.
It is slightly soluble in water and soluble in DMSO. For water-based or oral formulations, techniques such as micronization, cyclodextrin complexation, or lipid-based delivery systems are commonly used to improve dispersibility; DMSO is best reserved for research/cell-based work.
Yes, small research or evaluation samples are available on request so you can independently verify appearance, solubility, and purity before committing to a bulk order.
Yes. In addition to our internal CoA, we welcome buyers to send samples to an independent laboratory of their choice for third-party verification of purity, heavy metals, and microbial limits.
Yes, we support OEM/private-label packaging, custom specifications, and formulation guidance for customers developing supplement or functional-food finished products.
Standard packaging includes foil bags and fiber/plastic drums in various sizes (e.g., 25g/100g for research, 1kg/5kg/25kg for bulk). MOQ and lead times are flexible and depend on required purity grade and packaging format — contact us for a formal quotation.
Identity is confirmed by comparing HPLC retention time and UV spectral profile against a reference standard; buyers requiring additional confirmation (e.g., IR or mass spectrometry) can request this be arranged for a specific batch.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
Related Products
Spermidine Trihydrochloride Powder
Interested in UA?
Our R&D team will respond to your inquiry or sample request within 24 hours.
Scan to add WeChat
Alex Huang · Mon–Fri 9am–6pm CST
