Fisetin
Fisetin
Key Specifications
| CAS Number | 528-48-3 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₅H₁₀O₆ |
| Molecular Weight | 286.24 g/mol |
| Appearance | Yellow to orange powder |
| Solubility | Slightly soluble in water; soluble in ethanol |
| Storage | Room temperature, protect from light |
| Shelf Life | 24 months |
CAS 528-48-3
What Is Fisetin?
Fisetin is a naturally occurring plant flavonol in the flavonoid family, chemically known as 3,3',4',7-tetrahydroxyflavone (CAS 528-48-3, C15H10O6, MW 286.24 g/mol). It occurs in small amounts in strawberries, apples, persimmons, grapes, onions, and cucumbers, but commercial bulk material is produced from fisetin-rich botanical sources through extraction, concentration, and recrystallization to reach 98% purity. PathGene manufactures fisetin from Cotinus coggygria (smoke tree / smoke bush) bark and branches — the botanical source most commonly used by Chinese fisetin manufacturers. Some retail listings (particularly on Amazon and other consumer platforms) reference the same compound as "Rhus succedanea extract" or "wax tree extract." For B2B purchasing, buyers should confirm the Latin botanical name, plant part, extraction process, assay method, and batch traceability rather than comparing suppliers by source name alone.
Other Names
Key Features
High-Purity Flavonol
Standardized to ≥98% by the normalization (HPLC area) method, with a batch-specific Certificate of Analysis issued for every shipment.
Controlled Botanical Raw Material
Cotinus coggygria bark and branches are inspected for identity, appearance, and moisture before processing, with full batch traceability.
Fine Yellow Powder
Supplied as a characteristic yellow to orange powder with at least 95% passing an 80-mesh sieve; different particle sizes can be discussed for blending needs.
Full Contaminant Testing
Every batch is tested for lead, arsenic, cadmium, mercury, total plate count, yeast/mold, E. coli, and Salmonella.
Flexible Bulk & OEM Supply
Raw powder for ingredient distributors and supplement factories, plus OEM capsules, tablets, and powder blends for private-label brands.
| Molecular Formula | C₁₅H₁₀O₆ |
| Molecular Weight | 286.24 g/mol |
| Appearance | Yellow to orange powder |
| Solubility | Slightly soluble in water; soluble in ethanol |
| Storage Condition | Room temperature, protect from light |
| Shelf Life | 24 months |
| Grade 1 | Supplement Grade · ≥98.0% · COA |
End-Product Applications
Mechanism & Benefits
Natural antioxidant, scavenges free radicals, activates sirtuins. Senolytic activity, neuroprotection and anti-aging.
Packaging Options
100 g 500 g 1 kg
Lead Time
7–10 business days
Minimum Order
100 g
Custom Packaging
Custom packaging (foil bags, HDPE drums), GMP labeling, and export documentation are available. Contact us for specifics.Certifications
ISO
ISO
Manufacturing Process
1. Raw Material Selection
Qualified Cotinus coggygria bark and branches are inspected for identity, cleanliness, and moisture before processing.
2. Crushing
Dried plant material is crushed to a controlled particle size to increase surface area for extraction.
3. Soaking & Filtration
Crushed material is soaked under controlled conditions, then filtered to remove insoluble plant fibers.
4. Ethanol Extraction
Food-grade ethanol extracts the target flavonol fraction under controlled temperature, solvent ratio, and time.
5. Concentration
The filtered ethanol extract is concentrated under reduced pressure to remove solvent while limiting thermal exposure.
6. Recrystallization
The concentrated extract is purified via recrystallization — the critical step separating fisetin from pigments and plant residues.
7. Centrifugation & Drying
Purified crystals are separated by centrifugation, then dried and milled into a uniform yellow powder.
8. Quality Testing & Packaging
Each batch is tested for purity, appearance, particle size, heavy metals, and microbiological limits, then packed in sealed food-grade inner bags and protective drums.
Quality Specifications
| Test Item | Specification | Result |
|---|---|---|
| Appearance | Yellow to orange powder | Conforms |
| Odor | Characteristic | Conforms |
| Fisetin Purity | ≥98.0% (normalization method) | 98.2% |
| Particle Size | 95% passes 80 mesh | Conforms |
| Sulphated Ash | ≤1.0% | 0.6% |
| Loss on Drying | ≤2.0% | 1.1% |
| Lead (Pb) | ≤3 ppm | Conforms |
| Mercury (Hg) | ≤0.5 ppm | Conforms |
| Cadmium (Cd) | ≤1 ppm | Conforms |
| Arsenic (As) | ≤3 ppm | Conforms |
| Total Plate Count | ≤1,000 CFU/g | Conforms |
| Yeast and Mold | ≤100 CFU/g | Conforms |
| E. Coli | Negative | Negative |
| Salmonella | Negative | Negative |
Purity & Assay Method
Assay methods can produce different numerical results — an external reference-standard method typically reads lower than an area-normalization (HPLC) method. Our commercial specification is defined as ≥98% by the normalization method; a representative batch achieved 98.2% under this method. Buyers comparing quotations or COAs across suppliers should always confirm which analytical method was used. A batch-specific COA is issued with every shipment, and third-party HPLC testing can be arranged on request.
Solubility & Formulation
Fisetin has poor water solubility, which can limit dispersibility and oral bioavailability in conventional formulations; it is more compatible with organic solvents and lipid-based delivery systems. For supplement development, formulators commonly consider liposomal delivery systems, phospholipid complexes, micronized powder, oil-based softgel formulations, cyclodextrin inclusion complexes, nanoemulsions, or combination formulas with suitable carriers. PathGene can support raw-material selection and formulation guidance based on the intended dosage form.
Available Product Forms
Bulk Fisetin Powder
High-purity raw powder for supplement factories, research organizations, ingredient distributors, and contract manufacturers.
Fisetin Capsules
Custom capsule strength, shell material, bottle count, excipients, and label design for private-label brands.
Fisetin Tablets
Tablet formulation, granulation, compression, coating, bottle packaging, and custom labeling support.
Fisetin Powder Blends
Fisetin can be blended with complementary actives (antioxidants, other longevity ingredients, vitamins, minerals) per customer formula.
What is the standard purity of your fisetin powder?+
Our standard commercial grade is ≥98% by the normalization (HPLC) method. The exact result and analytical method are listed on the batch-specific COA.
What botanical source do you use?+
We manufacture fisetin from Cotinus coggygria (smoke tree/smoke bush) bark and branches, the source most commonly used by Chinese fisetin manufacturers.
Is Rhus succedanea extract the same as Cotinus coggygria extract?+
Both terms can appear in the commercial fisetin market and refer to fisetin-bearing plant sources, but buyers should confirm the exact botanical identity, plant part, and extraction process rather than relying on the source name alone.
Why do some retail listings mention Rhus succedanea extract?+
Rhus succedanea extract (also called wax tree or Japanese wax tree extract) is a name frequently used in consumer supplement listings, particularly on Amazon and other retail platforms, for the same compound class.
Is fisetin soluble in water?+
Fisetin has poor water solubility but is more soluble in ethanol and other organic solvents. See our Solubility & Formulation notes for delivery-system options.
Can I request a free sample?+
Qualified B2B buyers can request a free sample for formulation testing, identification, or quality evaluation before placing a commercial order.
Can you arrange third-party testing?+
Yes, third-party laboratory testing (including additional HPLC chromatograms) can be arranged according to customer requirements.
Do you offer OEM fisetin capsules, tablets, or liposomal formulations?+
Yes — we support custom capsule and tablet manufacturing, powder blending, and liposomal formulation development for private-label supplement brands.
Why Choose PathGene
- Direct China manufacturer supply — factory pricing, no middleman
- Batch-specific COA & full traceability on every shipment
- In-house R&D + synthetic biology / enzymatic production platform
- Free sample for qualified B2B buyers before commercial order
- Flexible MOQ — from lab-scale trial to ton-scale commercial supply
- One-stop OEM/private-label support for finished dosage forms
- Worldwide shipping by courier, air freight, and sea freight
OEM & Private-Label Services
- ·Custom capsule manufacturing
- ·Custom tablet manufacturing
- ·Powder blending & custom formulation
- ·Private-label bottles, pouches & labels
- ·Small trial orders
- ·Bulk commercial production
- ·Export documentation
- ·Third-party laboratory testing
Documents Available
- ·Certificate of Analysis (COA)
- ·Product specification sheet
- ·Material Safety Data Sheet (MSDS)
- ·Manufacturing flow chart
- ·HPLC test report
- ·Heavy-metal test report
- ·Microbiological test report
- ·Non-GMO / allergen statement
- ·Country-of-origin documentation
- ·Packing list & commercial invoice
Certificate availability should be confirmed with our sales team before ordering.
Sample Certificate of Analysis
PathGene Biotech Co., Ltd.
南京派琪生物科技有限公司
CERTIFICATE OF ANALYSIS
Layout example — not an issued batch record
Product Name
Fisetin
CAS No.
528-48-3
Batch No.
PG-SAMPLE-000000
Packaging
Issued upon order confirmation
| Test Item | Specification | Result |
|---|---|---|
| Appearance | Yellow to orange powder | Conforms |
| Odor | Characteristic | Conforms |
| Fisetin Purity | ≥98.0% (normalization method) | 98.2% |
| Particle Size | 95% passes 80 mesh | Conforms |
| Sulphated Ash | ≤1.0% | 0.6% |
| Loss on Drying | ≤2.0% | 1.1% |
| Lead (Pb) | ≤3 ppm | Conforms |
| Mercury (Hg) | ≤0.5 ppm | Conforms |
| Cadmium (Cd) | ≤1 ppm | Conforms |
| Arsenic (As) | ≤3 ppm | Conforms |
| Total Plate Count | ≤1,000 CFU/g | Conforms |
| Yeast and Mold | ≤100 CFU/g | Conforms |
| E. Coli | Negative | Negative |
| Salmonella | Negative | Negative |
Conclusion: Conforms to internal quality specifications
The COA issued with your order will carry the actual batch number, manufacture/test dates, and QC signature.
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Interested in Fisetin?
Our R&D team will respond to your inquiry or sample request within 24 hours.
