Fisetin
CAS 528-48-3
Purity≥98.0%
Flavonoid material for healthy-aging and formulation screening
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore healthy-aging ingredients.
Confirm assay method, particle form and oxidation protection.
Key Specifications
| Product Positioning | Flavonoid material for healthy-aging and formulation screening |
| Application Scenarios | polyphenol formulation screening · cell-aging research · poor-solubility delivery work |
| CAS Number | 528-48-3 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₅H₁₀O₆ |
| Molecular Weight | 286.24 g/mol |
| Appearance | Yellow to orange powder |
| Solubility | Slightly soluble in water; soluble in ethanol |
| Storage | Room temperature, protect from light |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Fisetin is a naturally occurring plant flavonol in the flavonoid family, chemically known as 3,3',4',7-tetrahydroxyflavone (CAS 528-48-3, C15H10O6, MW 286.24 g/mol). It occurs in small amounts in strawberries, apples, persimmons, grapes, onions, and cucumbers, but commercial bulk material is produced from fisetin-rich botanical sources through extraction, concentration, and recrystallization to reach 98% purity. PathGene manufactures fisetin from Cotinus coggygria (smoke tree / smoke bush) bark and branches — the botanical source most commonly used by Chinese fisetin manufacturers. Some retail listings (particularly on Amazon and other consumer platforms) reference the same compound as "Rhus succedanea extract" or "wax tree extract." For B2B purchasing, buyers should confirm the Latin botanical name, plant part, extraction process, assay method, and batch traceability rather than comparing suppliers by source name alone.
High-Purity Flavonol
Standardized to ≥98% by the normalization (HPLC area) method, with a batch-specific Certificate of Analysis issued for every shipment.
Controlled Botanical Raw Material
Cotinus coggygria bark and branches are inspected for identity, appearance, and moisture before processing, with full batch traceability.
Fine Yellow Powder
Supplied as a characteristic yellow to orange powder with at least 95% passing an 80-mesh sieve; different particle sizes can be discussed for blending needs.
Full Contaminant Testing
Every batch is tested for lead, arsenic, cadmium, mercury, total plate count, yeast/mold, E. coli, and Salmonella.
Flexible Bulk & OEM Supply
Raw powder for ingredient distributors and supplement factories, plus OEM capsules, tablets, and powder blends for private-label brands.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGFST-260514
Test date
2026-05-15
Specification
In-house
Pack size
25 kg/carton
Storage
Room temperature, protect from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | Yellow powder | Yellow powder |
| Identification | HPLC main peak retention time consistent with reference | Complies |
| Assay | ≥98.0% | 98.3% |
| Purity | ≥98.0% | 98.6% |
| Loss on drying | ≤5.0% | 2.8% |
| Ash | ≤5.0% | Complies |
| Lead (Pb) | ≤1.0 ppm | Complies |
| Mercury (Hg) | ≤0.5 ppm | Complies |
| Cadmium (Cd) | ≤1.0 ppm | Complies |
| Arsenic (As) | ≤0.5 ppm | Complies |
| Total microbial count | ≤1000 CFU/g | <10 |
| Coliform | ≤0.92 MPN/g | Complies |
| Mold and yeast | ≤100 CFU/g | Complies |
| Staphylococcus aureus | 0/25 g | Complies |
| Salmonella | 0/25 g | Complies |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
Multi-polyphenol hard-capsule products containing fisetin and quercetin already exist and can provide a practical formulation benchmark.
Evidence: Commercial-format rationale only. Direct human evidence proving fisetin–quercetin synergy was not identified; avoid translating animal or cell findings into a finished-product efficacy claim.Source
Literature-Supported Research Directions
Fisetin is studied as a flavonoid senolytic candidate. Preclinical work indicates intermittent treatment can reduce senescence markers and SASP-related signaling in aged or progeroid models.
Citation: Yousefzadeh et al., EBioMedicine (2018): fisetin as a senotherapeutic that extends health and lifespan in mice.View source
In old-mouse studies, intermittent fisetin supplementation was associated with lower vascular senescence, higher endothelial function and lower arterial stiffness. Translation to humans remains to be established.
Citation: Mahoney et al., Aging Cell (2024): fisetin and arterial function in old mice.View source
Recent animal research examined intermittent fisetin treatment in relation to frailty, grip strength and skeletal-muscle senescence pathways, providing a basis for further senescence-biology research.
Citation: Mahoney et al., Aging Cell (2025): fisetin, physical function and skeletal-muscle senescence in old mice.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
100 g
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
1. Raw Material Selection
Qualified Cotinus coggygria bark and branches are inspected for identity, cleanliness, and moisture before processing.
2. Crushing
Dried plant material is crushed to a controlled particle size to increase surface area for extraction.
3. Soaking & Filtration
Crushed material is soaked under controlled conditions, then filtered to remove insoluble plant fibers.
4. Ethanol Extraction
Food-grade ethanol extracts the target flavonol fraction under controlled temperature, solvent ratio, and time.
5. Concentration
The filtered ethanol extract is concentrated under reduced pressure to remove solvent while limiting thermal exposure.
6. Recrystallization
The concentrated extract is purified via recrystallization — the critical step separating fisetin from pigments and plant residues.
7. Centrifugation & Drying
Purified crystals are separated by centrifugation, then dried and milled into a uniform yellow powder.
8. Quality Testing & Packaging
Each batch is tested for purity, appearance, particle size, heavy metals, and microbiological limits, then packed in sealed food-grade inner bags and protective drums.
Assay methods can produce different numerical results — an external reference-standard method typically reads lower than an area-normalization (HPLC) method. Our commercial specification is defined as ≥98% by the normalization method; a representative batch achieved 98.2% under this method. Buyers comparing quotations or COAs across suppliers should always confirm which analytical method was used. A batch-specific COA is issued with every shipment, and third-party HPLC testing can be arranged on request.
Fisetin has poor water solubility, which can limit dispersibility and oral bioavailability in conventional formulations; it is more compatible with organic solvents and lipid-based delivery systems. For supplement development, formulators commonly consider liposomal delivery systems, phospholipid complexes, micronized powder, oil-based softgel formulations, cyclodextrin inclusion complexes, nanoemulsions, or combination formulas with suitable carriers. PathGene can support raw-material selection and formulation guidance based on the intended dosage form.
Our standard commercial grade is ≥98% by the normalization (HPLC) method. The exact result and analytical method are listed on the batch-specific COA.
We manufacture fisetin from Cotinus coggygria (smoke tree/smoke bush) bark and branches, the source most commonly used by Chinese fisetin manufacturers.
Both terms can appear in the commercial fisetin market and refer to fisetin-bearing plant sources, but buyers should confirm the exact botanical identity, plant part, and extraction process rather than relying on the source name alone.
Rhus succedanea extract (also called wax tree or Japanese wax tree extract) is a name frequently used in consumer supplement listings, particularly on Amazon and other retail platforms, for the same compound class.
Fisetin has poor water solubility but is more soluble in ethanol and other organic solvents. See our Solubility & Formulation notes for delivery-system options.
Qualified B2B buyers can request a free sample for formulation testing, identification, or quality evaluation before placing a commercial order.
Yes, third-party laboratory testing (including additional HPLC chromatograms) can be arranged according to customer requirements.
Yes — we support custom capsule and tablet manufacturing, powder blending, and liposomal formulation development for private-label supplement brands.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
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