Fisetin
CAS 528-48-3
Purity≥98.0%
Flavonoid material for healthy-aging and formulation screening
Fisetin Powder (CAS 528-48-3), specification ≥98.0%. Fisetin is a flavonoid ingredient evaluated by assay, particle size and dispersion alongside batch documentation. Batch COA and evaluation samples are available. MOQ: 100 g. healthy-aging ingredients
Quote / sample & delivery
Key Specifications
| Product Positioning | Flavonoid material for healthy-aging and formulation screening |
| Application Scenarios | polyphenol formulation screening · cell-aging research · poor-solubility delivery work |
| CAS Number | 528-48-3 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₅H₁₀O₆ |
| Molecular Weight | 286.24 g/mol |
| Appearance | Yellow to orange powder |
| Solubility | Slightly soluble in water; soluble in ethanol |
| Storage | Room temperature, protect from light |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Fisetin is a naturally occurring plant flavonol in the flavonoid family, chemically known as 3,3',4',7-tetrahydroxyflavone (CAS 528-48-3, C15H10O6, MW 286.24 g/mol). It occurs in small amounts in strawberries, apples, persimmons, grapes, onions, and cucumbers, but commercial bulk material is produced from fisetin-rich botanical sources through extraction, concentration, and recrystallization to reach 98% purity. PathGene manufactures fisetin from Cotinus coggygria (smoke tree / smoke bush) bark and branches — the botanical source most commonly used by Chinese fisetin manufacturers. Some retail listings (particularly on Amazon and other consumer platforms) reference the same compound as "Rhus succedanea extract" or "wax tree extract." For B2B purchasing, buyers should confirm the Latin botanical name, plant part, extraction process, assay method, and batch traceability rather than comparing suppliers by source name alone.
High-Purity Flavonol
Standardized to ≥98% by the normalization (HPLC area) method, with a batch-specific Certificate of Analysis issued for every shipment.
Controlled Botanical Raw Material
Cotinus coggygria bark and branches are inspected for identity, appearance, and moisture before processing, with full batch traceability.
Fine Yellow Powder
Supplied as a characteristic yellow to orange powder with at least 95% passing an 80-mesh sieve; different particle sizes can be discussed for blending needs.
Full Contaminant Testing
Every batch is tested for lead, arsenic, cadmium, mercury, total plate count, yeast/mold, E. coli, and Salmonella.
Flexible Bulk & OEM Supply
Raw powder for ingredient distributors and supplement factories, plus OEM capsules, tablets, and powder blends for private-label brands.
Test items, specifications and results for the listed batch are shown here. View or request a COA in the quality documents section.
Batch No.
PGFST-260514
Test date
2026-05-15
Specification
In-house
Pack size
25 kg/carton
Storage
Room temperature, protect from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | Yellow powder | Yellow powder |
| Identification | HPLC main peak retention time consistent with reference | Complies |
| Assay | ≥98.0% | 98.3% |
| Purity | ≥98.0% | 98.6% |
| Loss on drying | ≤5.0% | 2.8% |
| Ash | ≤5.0% | Complies |
| Lead (Pb) | ≤1.0 ppm | Complies |
| Mercury (Hg) | ≤0.5 ppm | Complies |
| Cadmium (Cd) | ≤1.0 ppm | Complies |
| Arsenic (As) | ≤0.5 ppm | Complies |
| Total microbial count | ≤1000 CFU/g | <10 |
| Coliform | ≤0.92 MPN/g | Complies |
| Mold and yeast | ≤100 CFU/g | Complies |
| Staphylococcus aureus | 0/25 g | Complies |
| Salmonella | 0/25 g | Complies |
View an available COA in the quality documents section. Check the document for its product form and batch; request a signed COA for your purchasing or shipment batch separately.
Hard capsules
Low water solubility guides carrier screening; resolve individual assay peaks in multi-polyphenol blends.
98.3%
Assay
98.6%
Purity
PGFST-260514 · Results apply to this lot; interpret purity, assay and water on their respective bases.
Composition candidates, processing sequences and tests support pilot design. Confirm candidate excipients and processes using this material in the actual finished formulation.
Application examples follow the materials, formats and findings actually studied. Combination studies, single-ingredient studies, commercial precedents and development candidates are distinguished.
Low aqueous solubility makes carrier selection important; phospholipid encapsulation differs from a simple powder blend.
Show research and formulation insights +Hide details −Combination / selection rationale: Low aqueous solubility makes carrier selection important; phospholipid encapsulation differs from a simple powder blend.
Published evidence / source details: A 2013 study prepared DOPC/DODA-PEG2000 fisetin liposomes, approximately 173.5 nm with 58% encapsulation, followed by cell and mouse experiments. It provides carrier characterization, not an oral raw-powder trial.
Development insights: Compare powder suspension, physical mixture and encapsulated material. Measure total/free fisetin, size, encapsulation and leakage; select suitable carriers and validate the actual process before calling a material liposomal.
Evidence scope: A specific experimental delivery system, without absorption, clinical or nanoscale-supply claims for this powder.
2013 · Seguin et al. · DOI 10.1016/j.ijpharm.2013.01.050 ↗A hard-capsule polyphenol blend requires separate specifications and assays rather than a total-polyphenol result alone.
Show research and formulation insights +Hide details −Combination / selection rationale: A hard-capsule polyphenol blend requires separate specifications and assays rather than a total-polyphenol result alone.
Published evidence / source details: The cited product lists fisetin, quercetin, trans-resveratrol and EGCG in HPMC capsules. It confirms a commercial format, not human evidence of synergy.
Development insights: Calculate total fill from individual assays; resolve polyphenol peaks and test uniformity, disintegration and oxidative colour. Premix low-level ingredients and record source and dissolution separately.
Evidence scope: Commercial precedent only; no transfer of another brand’s claims or clinical-synergy inference.
2026 · Manufacturer product ingredient list · checked 2026-10-23 ↗Literature-Supported Research Directions
Fisetin is studied as a flavonoid senolytic candidate. Preclinical work indicates intermittent treatment can reduce senescence markers and SASP-related signaling in aged or progeroid models.
Citation: Yousefzadeh et al., EBioMedicine (2018): fisetin as a senotherapeutic that extends health and lifespan in mice.View source
In old-mouse studies, intermittent fisetin supplementation was associated with lower vascular senescence, higher endothelial function and lower arterial stiffness. Translation to humans remains to be established.
Citation: Mahoney et al., Aging Cell (2024): fisetin and arterial function in old mice.View source
Recent animal research examined intermittent fisetin treatment in relation to frailty, grip strength and skeletal-muscle senescence pathways, providing a basis for further senescence-biology research.
Citation: Murray et al. Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches. Aging cell (2025). PMID: 40437670.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
100 g
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
1. Raw Material Selection
Qualified Cotinus coggygria bark and branches are inspected for identity, cleanliness, and moisture before processing.
2. Crushing
Dried plant material is crushed to a controlled particle size to increase surface area for extraction.
3. Soaking & Filtration
Crushed material is soaked under controlled conditions, then filtered to remove insoluble plant fibers.
4. Ethanol Extraction
Food-grade ethanol extracts the target flavonol fraction under controlled temperature, solvent ratio, and time.
5. Concentration
The filtered ethanol extract is concentrated under reduced pressure to remove solvent while limiting thermal exposure.
6. Recrystallization
The concentrated extract is purified via recrystallization — the critical step separating fisetin from pigments and plant residues.
7. Centrifugation & Drying
Purified crystals are separated by centrifugation, then dried and milled into a uniform yellow powder.
8. Quality Testing & Packaging
Each batch is tested for purity, appearance, particle size, heavy metals, and microbiological limits, then packed in sealed food-grade inner bags and protective drums.
Assay methods can produce different numerical results — an external reference-standard method typically reads lower than an area-normalization (HPLC) method. Our commercial specification is defined as ≥98% by the normalization method; a representative batch achieved 98.2% under this method. Buyers comparing quotations or COAs across suppliers should always confirm which analytical method was used. A batch-specific COA is issued with every shipment, and third-party HPLC testing can be arranged on request.
Fisetin has poor water solubility, which can limit dispersibility and oral bioavailability in conventional formulations; it is more compatible with organic solvents and lipid-based delivery systems. For supplement development, formulators commonly consider liposomal delivery systems, phospholipid complexes, micronized powder, oil-based softgel formulations, cyclodextrin inclusion complexes, nanoemulsions, or combination formulas with suitable carriers. PathGene can support raw-material selection and formulation guidance based on the intended dosage form.
Our standard commercial grade is ≥98% by the normalization (HPLC) method. The exact result and analytical method are listed on the batch-specific COA.
We manufacture fisetin from Cotinus coggygria (smoke tree/smoke bush) bark and branches, the source most commonly used by Chinese fisetin manufacturers.
No. Rhus succedanea and Cotinus coggygria identify different plants. Fisetin sourcing should distinguish botanical identity, plant part, extraction route and batch purity. A retail extract name alone does not qualify the source of a high-purity fisetin material.
Rhus succedanea extract (also called wax tree or Japanese wax tree extract) is a name frequently used in consumer supplement listings, particularly on Amazon and other retail platforms, for the same compound class.
Fisetin has poor water solubility but is more soluble in ethanol and other organic solvents. See our Solubility & Formulation notes for delivery-system options.
Qualified B2B buyers can request a free sample for formulation testing, identification, or quality evaluation before placing a commercial order.
Yes, third-party laboratory testing (including additional HPLC chromatograms) can be arranged according to customer requirements.
Yes — we support custom capsule and tablet manufacturing, powder blending, and liposomal formulation development for private-label supplement brands.
No. HPLC specification, particle size, aqueous dispersion and encapsulation are different attributes. This fisetin powder is not automatically a liposomal or cyclodextrin-complex grade. For a carrier project, compare powder suspension, physical mixture and the processed delivery system, checking assay, size, encapsulation where relevant and storage stability.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Check the COA for the applicable batch
Technical Resources
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