SAMe
CAS 97540-22-2
Salt Assay≥95.0% salt assay
SAMe p-toluenesulfonate sulfate powder for methyl-donor formulation development
SAMe disulfate tosylate powder (CAS 97540-22-2), with a ≥95.0% salt-assay specification. SAM-component content is a separate measure: batch PG03-260516 reports 51.2% SAM and 99.4% salt assay. Batch COA and evaluation samples are available. MOQ: 100 g. nutrition & functional ingredients
Quote / sample & delivery
Key Specifications
| Product Positioning | SAMe p-toluenesulfonate sulfate powder for methyl-donor formulation development |
| Application Scenarios | methylation research · pharmaceutical raw-material evaluation · nutraceutical formulation development |
| CAS Number | 97540-22-2 |
| Salt Assay | ≥95.0% salt assay |
| Molecular Formula | C22H34N6O16S4 |
| Molecular Weight | 766.8 g/mol (COA) |
| Appearance | White to off-white powder |
| Solubility | Soluble in water |
| Storage | Seal, protect from moisture and light; follow current COA storage instruction |
| Shelf Life | 2 years |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
S-Adenosylmethionine disulfate tosylate (SAMe, CAS 97540-22-2) is a salt material containing the SAM component, sulfate and p-toluenesulfonate. The company COA PG03-260516 identifies this exact salt and reports each composition measure separately. Salt assay must not be interpreted as the percentage of the SAM component. Store the hygroscopic material sealed in a cool, dry place.
Separate Assay Measures
Salt assay 95.0–105.0%; SAM component 49.5–54.7%, as specified in COA PG03-260516.
S,S-Isomer Testing
The dated COA reports 81.8% S,S-isomer proportion against a ≥60.0% specification.
Test items, specifications and results for the listed batch are shown here. View or request a COA in the quality documents section.
Batch No.
PG03-260516
Test date
2026-05-17
Specification
In-house
Pack size
25 kg/carton
Storage
Seal, protect from moisture and light; follow current COA storage instruction
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Sulfate | 23.5–26.5% | 25.4% |
| SAM component | 49.5–54.7% | 51.2% |
| p-Toluenesulfonic acid | 21.0–24.0% | 22.5% |
| Salt assay | 95.0–105.0% | 99.4% |
| S,S-isomer proportion | ≥60.0% | 81.8% |
| Water | ≤4.0% | 3.4% |
| pH | 1.0–2.0 | 1.2 |
| Heavy metals | ≤10 ppm | Complies |
View an available COA in the quality documents section. Check the document for its product form and batch; request a signed COA for your purchasing or shipment batch separately.
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
Separate salt mass, SAMe equivalents and active-isomer fraction; a ≥95% salt specification is not 95% active SAMe moiety.
99.4%
Salt assay
3.4%
Water
PG03-260516 · Results apply to this lot; interpret purity, assay and water on their respective bases.
Composition candidates, processing sequences and tests support pilot design. Confirm candidate excipients and processes using this material in the actual finished formulation.
Study combinations, individual-ingredient mechanisms and product precedents are distinguished; expand each entry for scope and pilot-development checks.
The 1975 study compared intravenous SAMe plus B12 with B12 in a hepatic-cirrhosis medical setting, not this oral salt plus methylfolate. Retain the methyl-metabolism rationale while checking SAMe equivalents, isomers and vitamin stability separately.
Expand research and formulation notes +Collapse research and formulation notes −Development rationale: The 1975 study compared intravenous SAMe plus B12 with B12 in a hepatic-cirrhosis medical setting, not this oral salt plus methylfolate. Retain the methyl-metabolism rationale while checking SAMe equivalents, isomers and vitamin stability separately.
Evidence scope: The 1975 study compared intravenous SAMe plus B12 with B12 in a hepatic-cirrhosis medical setting, not this oral salt plus methylfolate. Retain the methyl-metabolism rationale while checking SAMe equivalents, isomers and vitamin stability separately.
Pilot checks: Premix low-level vitamins; assay partners separately and test uniformity and light/moisture stability.
1975 · [Double-blind polycentric study of the action of S-adenosylmethionine in hepatic cirrhosis]. ↗Literature-Supported Research Directions
Public chemical databases list S-Adenosylmethionine p-Toluenesulfonate Sulfate under the stated identity; this reference supports identity review and does not replace the batch COA.
Citation: PubChem compound recordView source
A small open-label study in 20 healthy Chinese volunteers characterized SAMe after oral and intravenous administration of a tosylate-disulfate salt, using a validated LC–MS assay. The salt description and finished dosage forms in the paper must be compared carefully with the supplied p-toluenesulfonate sulfate; equivalence should not be assumed.
Citation: Yang et al. Clinical Therapeutics. 2009;31(2):311–320.View source
A rat pharmacokinetic study compared a SAMe phytate preparation with a tosylated form and reported different exposure parameters. This illustrates why counterion and formulation matter, but animal data do not establish human performance or equivalence for this product.
Citation: Francioso et al. Pharmacokinetic properties of a novel formulation of S-adenosyl-L-methionine phytate. Amino acids (2021). PMID: 34536129.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
100 g
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
The reviewed COA defines salt assay at 95.0–105.0%, SAM component at 49.5–54.7% and S,S-isomer proportion at ≥60.0%. These are independent measures; reported batch values are not universal specifications.
Formulation work should confirm concentration, pH, light, moisture and hold-time controls for S-Adenosylmethionine p-Toluenesulfonate Sulfate; suitability depends on the final format and market requirements.
No. Salt assay describes the entire specified salt. PG03-260516 reports 99.4% salt assay and 51.2% SAM component.
The COA for SAMe p-toluenesulfonate sulfate lot PG03-260516 reports 99.4% salt assay, 51.2% SAM component, 25.4% sulfate, 22.5% p-toluenesulfonic acid and 81.8% S,S-isomer proportion. These are separate fields for that lot. Assess the offered material using its own COA.
The previous URL was a legacy page identifier. The supplied material is S-adenosyl-L-methionine disulfate tosylate, CAS 97540-22-2, as identified in COA PG03-260516. Use this CAS and salt name in the purchase specification. The reported salt assay of 99.4%, SAM-component content of 51.2% and S,S-isomer proportion of 81.8% are three separate results for that batch.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Check the COA for the applicable batch
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