Carnosine
CAS 305-84-0
Purity≥98.0%
Dipeptide material for muscle and cellular-aging research
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore nutrition & functional ingredients.
Confirm L-carnosine identity and solution stability.
Key Specifications
| Product Positioning | Dipeptide material for muscle and cellular-aging research |
| Application Scenarios | dipeptide cell research · sports-nutrition formulation · water-based cosmetic screening |
| CAS Number | 305-84-0 |
| Purity | ≥98.0% |
| Molecular Formula | C₉H₁₄N₄O₃ |
| Molecular Weight | 226.23 g/mol |
| Appearance | White crystalline powder |
| Solubility | Freely soluble in water |
| Storage | Room temperature, dry |
| Shelf Life | 36 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
L-Carnosine is a naturally occurring dipeptide formed from the amino acids beta-alanine and L-histidine (CAS 305-84-0; molecular formula C9H14N4O3; MW 226.23 g/mol). It occurs endogenously at high concentrations in the skeletal muscle, cardiac tissue, and brain of vertebrates, where it contributes to intracellular pH buffering and cellular protection. For commercial supply, bulk L-carnosine is produced through a biotechnology-based route: the two precursor amino acids, L-histidine and beta-alanine, are first obtained by microbial fermentation, then joined through a controlled enzymatic coupling step that forms the characteristic beta-amino peptide bond. The resulting dipeptide is purified by crystallization and dried into a white crystalline powder of ≥98.0% purity, suitable for dietary supplement, cosmetic, and pharmaceutical-grade raw material applications.
High, Verified Purity
Each production batch is assayed at ≥98.0% purity by HPLC, with a batch-specific certificate of analysis issued for every shipment.
Controlled Bio-Based Production
Precursor amino acids are produced via microbial fermentation and joined through a tightly controlled enzymatic coupling process, reducing residual solvents and by-products versus purely chemical routes.
Consistent Crystalline Form
Supplied as a free-flowing white crystalline powder with consistent particle size, appearance, and odor from batch to batch.
Full Contaminant Screening
Every lot is screened for heavy metals (Pb, Hg, Cd, As) and microbial limits to meet food-grade, cosmetic-grade, and pharmaceutical raw material requirements.
Flexible Bulk & OEM Supply
Available in bulk quantities with customizable packaging, particle size, and private-label documentation to support OEM/ODM programs.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PG04-260522
Test date
2026-05-23
Specification
In-house
Pack size
25kg/carton
Storage
Room temperature, dry
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White crystalline powder | Conforms |
| Odor | Characteristic, no off-odor | Conforms |
| Assay (HPLC) | ≥98.0% | 99.1% |
| pH (1% aqueous solution) | 7.0 - 8.5 | 7.8 |
| Loss on Drying | ≤0.5% | 0.22% |
| Particle Size / Crystal Form | Fine crystalline powder, through 80 mesh ≥95% | Conforms |
| Lead (Pb) | ≤2 mg/kg | <1 mg/kg |
| Arsenic (As) | ≤2 mg/kg | <1 mg/kg |
| Mercury (Hg) | ≤1 mg/kg | <0.5 mg/kg |
| Cadmium (Cd) | ≤1 mg/kg | <0.5 mg/kg |
| Total Plate Count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mold | ≤100 CFU/g | <10 CFU/g |
| E. coli | Negative/25 g | Negative |
| Salmonella | Negative/25 g | Negative |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
Serum
Cream
Sheet masks
Screen for anti-glycation, carbonyl-stress and redox-homeostasis concepts; cosmetic formulas should prioritize skin feel, delivery and system stability.
Evidence: Mechanistic and explant evidence; finished formulas require separate validation.Source
Literature-Supported Research Directions
Carnosine is studied in carbonyl stress, advanced glycation end-products (AGEs) and cytoprotection, including protein cross-linking, oxidative stress and tissue-aging mechanisms.
Citation: Miele et al., Clinical Interventions in Aging (2018), topical carnosine and antiglycation activity in human skin explants.View source
Carnosine is also used in research on muscle buffering capacity, exercise metabolism and fatigue-related mechanisms. Human outcomes depend on training status, dose and finished-product design and should be framed as research and formulation work.
Citation: Derave et al., Sports Medicine (2010), review of carnosine, buffering and exercise performance.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
1 kg
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Precursor Amino Acid Fermentation
Selected microbial strains ferment renewable feedstocks to produce the two building-block amino acids, L-histidine and beta-alanine, in separate fermentation streams.
Precursor Recovery and Purification
Fermentation broths are clarified, and each amino acid is recovered by ion-exchange chromatography and crystallization to high purity.
Enzymatic Dipeptide Coupling
Purified L-histidine and beta-alanine are combined under controlled temperature and pH in a biocatalytic coupling reaction that forms the beta-amino peptide bond characteristic of carnosine.
Reaction Quench and Clarification
The coupling reaction is quenched, and the crude solution is filtered to remove residual biomass, spent catalyst, and insoluble by-products.
Chromatographic Purification
The clarified solution undergoes ion-exchange and/or resin-based chromatography to remove unreacted precursors and trace impurities.
Crystallization
The purified carnosine solution is concentrated and crystallized under controlled cooling conditions to yield uniform crystals.
Drying and Milling
Crystals are dried under vacuum, then milled and sieved to achieve the target particle size and a free-flowing white powder.
Quality Control and Packaging
Each batch is tested against the full quality specification (assay, heavy metals, microbial limits) before being packaged under controlled conditions for shipment.
Purity is determined by high-performance liquid chromatography (HPLC), typically using a reverse-phase or ion-pair column referenced against a certified L-carnosine standard, with content calculated as the area percentage of the main peak. Buyers should confirm the specific HPLC method, mobile phase, and reference standard applied, and request a batch-specific certificate of analysis (COA) confirming the material meets the ≥98.0% purity specification before finalizing an order.
L-carnosine is freely soluble in water, making it well suited for aqueous formulations such as functional beverages, effervescent tablets, oral solutions, and water-based cosmetic serums. It is comparatively less soluble in ethanol and other organic solvents, so formulators working with anhydrous or oil-based systems may need co-solvents, micronized grades, or microencapsulation technology to improve dispersibility. As a zwitterionic dipeptide, its solubility and stability can be influenced by formulation pH and the presence of reducing sugars (Maillard-type interactions), which should be evaluated during product development.
Yes. Every batch is assayed at ≥98.0% purity by HPLC, and a batch-specific certificate of analysis (COA) covering assay, heavy metals, and microbial limits is issued with each shipment.
Our L-carnosine is produced through a biotechnology-based process: the precursor amino acids are obtained via microbial fermentation, then joined by a controlled enzymatic coupling step. This is not derived from animal tissue extraction.
Yes, L-carnosine is freely soluble in water, which makes it suitable for beverages, effervescent products, and other aqueous formulations. Solubility in ethanol and oils is limited, so oil-based systems may require additional formulation support.
Yes, small samples are available on request for formulation trials and quality evaluation prior to committing to a bulk order.
Yes. We operate under our internal quality management system and are glad to accommodate third-party or customer-designated laboratory testing of samples prior to or after shipment.
Yes, we support OEM/ODM programs including custom labeling, private-label documentation, and packaging tailored to customer specifications.
Standard bulk packaging is in moisture-proof, double-lined drums or bags (e.g., 1 kg, 5 kg, and 25 kg), with custom sizes and packaging materials available on request.
MOQ is flexible and depends on whether the order is for a trial sample or a bulk purchase; please contact us with your target quantity and application to receive a formal quotation along with the current COA and specification sheet.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
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Alex Huang · Mon–Fri 9am–6pm CST
