DHB
CAS 483-15-8
Purity≥98.0%
Berberine derivative for metabolic-nutrition formulation research
Dihydroberberine Powder (CAS 483-15-8), specification ≥98.0%. Dihydroberberine (DHB) is a reduced berberine derivative with its own ingredient identity, distinct from berberine hydrochloride. Batch COA and evaluation samples are available. MOQ: 1 kg. nutrition & functional ingredients
Quote / sample & delivery
Key Specifications
| Product Positioning | Berberine derivative for metabolic-nutrition formulation research |
| Application Scenarios | alkaloid absorption research · metabolic-nutrition formulas · capsule compatibility screening |
| CAS Number | 483-15-8 |
| Purity | ≥98.0% |
| Molecular Formula | C₂₀H₁₉NO₄ |
| Molecular Weight | 337.37 g/mol |
| Appearance | Light yellow to yellow crystalline powder |
| Solubility | Slightly soluble in water; soluble in DMSO and ethanol |
| Storage | Sealed, protected from light; store at 2–8°C; long-term storage at −20°C |
| Shelf Life | 24 months at 2–8°C |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Dihydroberberine (DHB, CAS 483-15-8) is a reduced berberine derivative with molecular formula C20H19NO4 and molecular weight 337.37 g/mol. It is supplied as a light yellow to yellow crystalline powder for dietary-supplement and formulation research. Its reported physicochemical profile and oxidation sensitivity should be confirmed against the batch specification before production. Dihydroberberine is a different ingredient from berberine hydrochloride (berberine HCl, CAS 633-65-8). Confirm the chemical identity and use the matching specification and batch COA when selecting between them.
High-Purity Assay
Purity ≥98.0% verified by HPLC against a qualified reference standard, batch-to-batch consistent for demanding formulation needs.
Controlled Semi-Synthesis
Produced from selected berberine-rich plant feedstock through a tightly controlled catalytic reduction step, ensuring reaction consistency and traceability from raw material to finished powder.
Uniform Yellow Crystalline Form
Supplied as a free-flowing yellow crystalline powder with controlled particle size for consistent dosing, blending, and capsule/tablet processing.
Full Contaminant Screening
Every batch is screened for heavy metals (Pb, Hg, Cd, As), residual solvents, and microbial limits, with a full Certificate of Analysis provided.
Flexible Bulk & OEM Supply
Available in flexible order quantities from sample to bulk drums, with OEM/private-label formulation, custom packaging, and documentation support.
| Molecular Formula | C₂₀H₁₉NO₄ |
| Molecular Weight | 337.37 g/mol |
| Appearance | Light yellow to yellow crystalline powder |
| Solubility | Slightly soluble in water; soluble in DMSO and ethanol |
| Storage Condition | Sealed, protected from light; store at 2–8°C; long-term storage at −20°C |
| Shelf Life | 24 months at 2–8°C |
| Grade 1 | Supplement Grade · ≥98.0% · Specification sheet |
| Test Item | Specification |
|---|---|
| Appearance | Light yellow to yellow crystalline powder |
| Chemical name | 9,10-Dimethoxy-2,3-(methylenedioxy)-5,8-dihydroberberine |
| Solubility | Slightly soluble in water; soluble in DMSO and ethanol |
| Melting point | 218–220°C |
| Loss on drying | ≤1.0% |
| Heavy metals | ≤10 ppm |
| Assay (HPLC) | ≥98.0% |
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
Document dihydroberberine separately from berberine hydrochloride; do not transfer loading or absorption findings to blend efficacy.
Composition candidates, processing sequences and tests support pilot design. Confirm candidate excipients and processes using this material in the actual finished formulation.
Study combinations, individual-ingredient mechanisms and product precedents are distinguished; expand each entry for scope and pilot-development checks.
Gut microbiota and berberine metabolism provide a rationale for evaluating dihydroberberine with probiotic or fiber systems. Current human evidence is stronger for berberine or dihydroberberine alone than for this exact combination.
Expand research and formulation notes +Collapse research and formulation notes −Development rationale: Gut microbiota and berberine metabolism provide a rationale for evaluating dihydroberberine with probiotic or fiber systems. Current human evidence is stronger for berberine or dihydroberberine alone than for this exact combination.
Evidence scope: Indirect evidence: a randomized study evaluated berberine with Bifidobacterium; it should not be presented as direct proof for dihydroberberine synergy.
Pilot checks: Premix low-level ingredients before bulk powders; record size/density differences and test segregation, fill mass and reconstitution sensory properties. Set separate stability tests for strains and nutritional ingredients; compare late addition with separate packaging and measure end-of-shelf-life viable counts.
2021 · Effectiveness and safety of Bifidobacterium and berberine in human hyperglycemia and their regulatory effect on the gut microbiota: a multi-center, double-blind, randomized, parallel-controlled study. ↗Literature-Supported Research Directions
Dihydroberberine supports research into berberine metabolism, AMPK signaling and glucose/insulin responses. An initial human crossover study mainly showed exposure differences and does not establish a consistent clinical glucose-lowering effect.
Citation: Moon et al. Absorption Kinetics of Berberine and Dihydroberberine and Their Impact on Glycemia: A Randomized, Controlled, Crossover Pilot Trial. Nutrients (2021). PMID: 35010998.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
1 kg
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Insulated Box + Carton
For products requiring temperature-controlled transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Botanical Raw Material Selection
Berberine-rich botanical material (e.g., Coptis chinensis rhizome or Phellodendron amurense bark) is sourced and screened for berberine content prior to processing.
Extraction of Berberine
The plant material is extracted using acidified aqueous or ethanol-based solvent systems to solubilize the berberine alkaloid fraction.
Purification to Berberine Intermediate
Crude extract is purified via crystallization and/or ion-exchange processing to obtain a pharmaceutical-grade berberine salt (e.g., berberine hydrochloride) intermediate.
Catalytic Reduction (Hydrogenation)
The purified berberine salt is reacted with a hydrogen donor (hydrogen gas, or agents such as ammonium formate/isopropanol) over a supported metal catalyst (e.g., Pd/C or Raney nickel) under mildly alkaline, temperature-controlled conditions, converting the quaternary iminium of berberine into the dihydro (tertiary enamine) form.
Catalyst Removal & Neutralization
The reaction mixture is filtered to remove the metal catalyst and neutralized to precipitate the dihydroberberine free base.
Crystallization
Controlled cooling and/or anti-solvent crystallization yields dihydroberberine as a defined yellow crystalline solid.
Washing, Drying & Milling
Crystals are washed to remove residual salts and mother liquor, vacuum-dried to target moisture/loss-on-drying, then milled and sieved for uniform particle size.
Quality Control & Packaging
Finished material undergoes HPLC assay, heavy metal, residual solvent, and microbial testing before being packaged under light- and moisture-protected conditions.
Purity is determined by reverse-phase HPLC with UV detection, quantified against a qualified dihydroberberine reference standard and reported on an as-is basis. Because dihydroberberine can be air- and light-sensitive and may partially reoxidize toward berberine under poor storage conditions, buyers should confirm the assay method, reference standard traceability, and related-substance/impurity profile on the batch-specific Certificate of Analysis before formulation, and request re-test data for material held longer than the recommended retest interval.
Dihydroberberine is slightly soluble in water but readily soluble in ethanol and other organic solvents, reflecting the increased lipophilicity gained when the parent alkaloid's quaternary ammonium group is reduced to a tertiary amine. For finished-product formulation, this profile favors oil-based softgel suspensions, lipid or self-emulsifying (SEDDS/SMEDSS) delivery systems, or micronization/particle-size reduction combined with wetting agents to improve dispersibility in aqueous or powder-blend applications. Buyers formulating aqueous or effervescent products should pilot-test dispersion and consider co-processing with solubilizers or carrier excipients.
Standard grade is ≥98.0% purity by HPLC, supplied as a yellow crystalline powder with full heavy metal and microbial testing. A batch-specific Certificate of Analysis is provided with every shipment; higher-purity or custom specifications can be discussed on request.
It is manufactured semi-synthetically: berberine is first extracted and purified from selected berberine-rich botanical raw material, then converted to dihydroberberine through a controlled catalytic reduction step, followed by crystallization, drying, and quality testing.
It is slightly soluble in water and readily soluble in ethanol. For most finished products, oil-based softgel suspensions, lipid delivery systems, or micronized powder blends with a wetting agent give the most consistent results; our technical team can advise based on your target dosage form.
Yes, small samples are available for formulation testing and internal evaluation. Please contact our sales team with your intended application and shipping details to arrange a sample.
Yes. In addition to our in-house Certificate of Analysis, we support sending samples to a third-party laboratory of the buyer's choice for independent verification of purity, heavy metals, and microbial limits.
Yes, we offer OEM/ODM and private-label support, including custom blends, capsule/tablet formulation assistance, and packaging design tailored to your brand requirements.
Standard packaging includes 1 kg and 25 kg fiber drums with double food-grade polyethylene liners to protect against moisture and light; custom packaging sizes and labeling can be arranged for larger or OEM orders.
The raw-material MOQ for dihydroberberine powder is 1 kg, with pack options of 1 kg, 25 kg. Typical lead time is 3–5 business days, with dispatch confirmed for the order.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Technical Resources
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Alex Huang · Mon–Fri 9am–6pm CST
