Berberine
CAS 633-65-8
Purity≥97.0%
Berberine salt for botanical and nutrition formulation development
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore nutrition & functional ingredients.
Confirm hydrochloride salt and assay calculation basis.
Key Specifications
| Product Positioning | Berberine salt for botanical and nutrition formulation development |
| Application Scenarios | botanical active research · nutrition capsule formulas · aqueous salt-formulation screening |
| CAS Number | 633-65-8 |
| Purity | ≥97.0% |
| Molecular Formula | C₂₀H₁₈ClNO₄ |
| Molecular Weight | 371.82 g/mol |
| Appearance | Yellow crystalline powder |
| Solubility | Slightly soluble in water; soluble in hot water |
| Storage | Room temperature, protect from light |
| Shelf Life | 36 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Berberine hydrochloride (CAS 633-65-8, C20H18ClNO4, MW 371.82 g/mol) is the hydrochloride salt of berberine, a quaternary isoquinoline alkaloid naturally occurring in the roots, rhizomes and bark of plants such as Coptis chinensis (Chinese goldthread), Phellodendron amurense (Amur cork tree), Berberis species and Hydrastis canadensis (goldenseal). It presents as a yellow crystalline powder and is one of the most widely used botanical alkaloids in the nutraceutical and pharmaceutical API markets. At commercial scale, berberine hydrochloride is not chemically synthesized from petrochemical feedstocks; instead it is produced by extracting the alkaloid-rich plant raw material with aqueous or ethanol-based solvents, followed by acid-base purification, concentration, salt formation with hydrochloric acid, and recrystallization to reach pharmaceutical- or food-grade purity.
High, Consistently Verified Purity
Each batch is assayed by HPLC to confirm purity of ≥97.0%, meeting the requirements for pharmaceutical API and high-grade dietary supplement applications.
Controlled Botanical Raw Material Sourcing
Raw plant material (primarily Coptis chinensis rhizome) is sourced from qualified, traceable suppliers and identity-tested before extraction to ensure consistent alkaloid content batch after batch.
Uniform Crystalline Appearance
Supplied as a free-flowing yellow crystalline powder with controlled particle size, suitable for direct compression, encapsulation or further formulation.
Comprehensive Contaminant Screening
Every lot is screened for heavy metals (Pb, As, Hg, Cd), residual solvents and microbial limits, with full certificates of analysis available on request.
Flexible Bulk & OEM Supply
Available in flexible bulk packaging (1kg to 25kg drums) with OEM/private-label formulation, custom particle size and documentation support for global B2B buyers.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGBH-260416
Test date
2026-04-17
Specification
In-house
Pack size
25kg/carton
Storage
Room temperature, protect from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | Yellow crystalline powder | Conforms, yellow crystalline powder |
| Odor | Odorless or faint characteristic odor | Conforms |
| Identification | Positive by UV/HPLC characteristic retention time | Conforms |
| Assay (Berberine HCl, HPLC) | ≥97.0% | 97.6% |
| Particle Size | 100% pass 80 mesh (or as customer-specified) | 98.5% pass 80 mesh |
| Loss on Drying | ≤5.0% | 2.8% |
| Residue on Ignition (Sulfated Ash) | ≤0.5% | 0.2% |
| Heavy Metals (Pb) | ≤10 mg/kg | <5 mg/kg |
| Arsenic (As) | ≤2 mg/kg | <1 mg/kg |
| Mercury (Hg) | ≤1 mg/kg | <0.5 mg/kg |
| Cadmium (Cd) | ≤1 mg/kg | <0.5 mg/kg |
| Total Plate Count | ≤1000 CFU/g | <500 CFU/g |
| Yeast & Mold | ≤100 CFU/g | <50 CFU/g |
| E. coli / Salmonella | Negative | Negative |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
A randomized study examined glycemic and microbiome outcomes and can inform metabolic/microbiome formulation development; strain, dose and drug interactions require assessment.
Evidence: Human combination evidence exists but cannot be generalized to all strains or ratios.Source
Literature-Supported Research Directions
Berberine hydrochloride is widely studied for AMPK, gut-microbiome and glucose/lipid metabolism. Trials and meta-analyses suggest possible metabolic improvements, but dose, drug interactions and gastrointestinal tolerability require product-specific assessment.
Citation: Liu et al., Diabetes Care (2023), systematic review and meta-analysis of berberine and glycemic traits.View source
Berberine can be screened with probiotics, dietary fiber and other metabolic ingredients. A human study has examined berberine with Bifidobacterium, but results cannot be generalized to every ratio or finished product.
Citation: Zhang et al., Frontiers in Endocrinology (2021), randomized human study of berberine plus Bifidobacterium.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
1 kg
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
CP
Chinese Pharmacopoeia
Raw Material Selection & Identity Testing
Qualified Coptis chinensis rhizome (or other berberine-rich botanical raw material) is sourced, identity-verified and pre-assayed for alkaloid content before being released to production.
Crushing & Pretreatment
The dried plant material is crushed to a suitable particle size to increase surface area and improve extraction efficiency in the subsequent solvent extraction step.
Solvent Extraction
The crushed material is extracted with acidified water or ethanol under controlled temperature and time to dissolve out the total alkaloid fraction, including berberine.
Acid-Base Purification
The crude extract undergoes acid-base treatment (and, where applicable, ion-exchange or resin adsorption) to remove pigments, polysaccharides, proteins and other co-extracted impurities, concentrating the berberine fraction.
Concentration & Salt Formation
The purified alkaloid solution is concentrated under reduced pressure and treated with hydrochloric acid to convert berberine into its more stable, crystalline hydrochloride salt form.
Crystallization & Recrystallization
Berberine hydrochloride is crystallized out under controlled cooling conditions, and recrystallized as needed to remove residual impurities and achieve the target purity of ≥97.0%.
Filtration, Washing & Drying
The crystals are separated by filtration, washed to remove mother liquor residues, and dried under controlled temperature to obtain a stable, low-moisture powder.
Milling, QC Testing & Packaging
The dried crystals are milled/sieved to the target particle size, sampled for full quality control testing (assay, appearance, heavy metals, microbial limits), and packed under moisture-protected conditions.
Purity is determined by high-performance liquid chromatography (HPLC) against a reference standard, in line with pharmacopoeial methods commonly used for berberine hydrochloride. Buyers should request the batch-specific certificate of analysis (COA) confirming the HPLC assay method, reference standard traceability, and acceptance criteria (≥97.0%) before finalizing purchase, and are welcome to arrange independent third-party verification.
Berberine hydrochloride is slightly soluble in cold water but soluble in hot water, and only sparingly soluble in ethanol, which should be factored into formulation and process design. For oral solid dosage forms (tablets, capsules), standard direct-blend or wet-granulation techniques are typically suitable; for liquid or beverage applications, gentle heating, micronization, or the use of solubilizers/carrier systems (e.g., cyclodextrins, phospholipid complexes) can help improve dispersibility. Customers developing new formats are encouraged to request a small sample for compatibility and dissolution trials before scale-up.
Every batch is tested by HPLC against a certified reference standard, and a full certificate of analysis (COA) with the purity result, appearance, heavy metals and microbial data is provided with each shipment.
Our berberine hydrochloride is produced from qualified, identity-verified plant raw material (primarily Coptis chinensis rhizome) through solvent extraction, acid-base purification, salt formation with hydrochloric acid, and recrystallization — not petrochemical chemical synthesis.
It is slightly soluble in water at room temperature but more soluble in hot water, and only sparingly soluble in ethanol. This should be considered when designing tablets, capsules, or liquid formats, and we can advise on suitable approaches based on your intended application.
Yes, small free or low-cost samples are available for quality evaluation, dissolution testing, or formulation trials prior to committing to a bulk purchase order.
Yes, in addition to our internal COA for every batch, we support and cooperate with independent third-party laboratory testing requested by customers for purity, contaminants, or other specifications.
Yes, we offer OEM/private-label supply including custom particle size, custom blends, and customer-branded packaging and labeling for finished dietary supplement or API customers.
Standard packaging includes moisture-protected drums or bags in 1kg, 5kg, and 25kg formats, with custom packaging sizes and materials available on request for larger orders.
MOQ varies by packaging format and application; please contact our sales team with your target volume, purity requirement, and destination country to receive a detailed quotation and lead time.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
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Alex Huang · Mon–Fri 9am–6pm CST
