What is Trigonelline Hydrochloride?

Trigonelline Hydrochloride is the hydrochloride salt of trigonelline. Its CAS number is 6138-41-6, formula C7H7NO2·HCl, and molecular weight 173.60 g/mol.

Is Trigonelline Hydrochloride water soluble?

The referenced COA describes it as freely soluble in water and reports a clear, colorless solution. Confirm clarity and compatibility under the target concentration and pH.

What quality data are available?

The COA includes appearance, odor, solubility, solution clarity and color, HPLC purity, loss on drying, water, residue on ignition, heavy metals, lead, arsenic and microbial limits. The referenced batch reports water of 0.09% and loss on drying of 0.06%.

What formulation and research areas are relevant?

It can be evaluated for nutrition ingredient development, botanical active research and water-based formulation screening. Application claims should be based on the buyer's regulatory and product-market requirements.

What packaging and storage are listed?

The referenced COA lists 25 kg/drum packaging and sealed, cool, dry, light-protected storage.

Trigonelline HCl

CAS 6138-41-6

Trigonelline Hydrochloride

Q: What purity is reported for the Trigonelline Hydrochloride batch?

Batch PGTHC-260510 reports 99.9% HPLC purity against a specification of ≥98.0%.

Purity≥98%

Trigonelline salt for NAD+-linked nutrition research

For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore nutrition & functional ingredients.

Confirm hydrochloride salt, water solubility and molar conversion basis.

MW173.60 g/mol

Trigonelline Hydrochloride (CAS 6138-41-6) bulk active ingredient

Key Specifications

Product Positioning	Trigonelline salt for NAD+-linked nutrition research
Application Scenarios	botanical nutrition formulas · NAD+-linked research · water-based formulation screening
CAS Number	6138-41-6
Purity	≥98%
Molecular Formula	C7H7NO2·HCl
Molecular Weight	173.60 g/mol
Appearance	White fine powder
Solubility	Freely soluble in water
Storage	Sealed packaging; store cool, dry and away from light.
Shelf Life	24 months

Procurement & delivery

Supply details confirmed by intended use, volume and target market

Purity ≥98%CAS 6138-41-6

MOQContact us

Lead Time3–5 business days

Packaging25 kg/drum

View quality documents ↓

What Is Trigonelline HCl?

Trigonelline hydrochloride (CAS 6138-41-6) is the hydrochloride salt of trigonelline, supplied as a white, water-soluble powder. The referenced batch includes HPLC purity, water, loss on drying, residue and microbial controls for formulation and research use.

Other Names

Trigonelline HydrochlorideTrigonelline HClCAS 6138-41-6

Key Features

🧪

99.9% HPLC Purity in the Referenced Batch

The referenced batch PGTHC-260510 reports 99.9% HPLC purity against a specification of ≥98.0%.

💧

Water-Soluble Powder Form

Supplied as a white, water-soluble powder; the referenced COA records a clear, colorless solution.

🔬

Moisture, Residue & Microbial Controls

The batch COA records water, loss on drying, residue on ignition, heavy metals and microbiological limits.

Recent batch test data

Test items, specifications and batch results are shown here; request the formal COA through the card below.

Batch No.

PGTHC-260510

Test date

2026-05-11

Specification

In-house

Pack size

25 kg/drum

Storage

Sealed packaging; store cool, dry and away from light.

Conclusion

Conforms

Test Item	Specification	Result
Appearance	White fine powder	White fine powder
Odor	Characteristic odor	Complies
Solubility	Freely soluble in water	Complies
Clarity and color	Clear and colorless	Complies
Loss on drying	≤0.3%	0.06%
Purity (HPLC)	≥98.0%	99.9%
Water	≤1.0%	0.09%
Residue on ignition	≤1.0%	0.04%
Heavy metals	≤0.5 mg/kg	Complies
Lead (Pb)	≤0.5 mg/kg	Complies
Arsenic (As)	≤0.5 mg/kg	Complies
Total aerobic count	≤500 CFU/g	<10 CFU/g
Total yeasts and molds	≤50 CFU/g	<10 CFU/g
Pathogens	All negative	Complies

This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.

Literature-Supported Research Directions

Scientific Research

1. NAD⁺ Precursor and Preiss–Handler Pathway

A 2024 multi-species study reported that trigonelline enters the NAD⁺ pool through the NAPRT-dependent Preiss–Handler pathway. Human serum trigonelline was lower in sarcopenia and correlated with muscle strength and oxidative-phosphorylation signatures, while causal muscle-function findings came from cells, C. elegans and mice rather than a human supplementation efficacy trial.

Citation: Membrez et al., Nature Metabolism 6 (2024), 433–447. DOI: 10.1038/s42255-024-00997-x.View source

2. Muscle Mitochondria and Age-Related Function

In the same study, trigonelline increased NAD⁺ in primary myotubes and improved mitochondrial respiration, age-related muscle wasting and mobility in preclinical models; dietary supplementation also increased strength and reduced fatigue in aged male mice. These outcomes support a healthy-aging and muscle-formulation research direction but do not establish efficacy in older adults.

Citation: Membrez et al., Nature Metabolism 6 (2024), 433–447.View source

3. Acute Glucose and Insulin Response in Humans

In a randomized crossover study of 15 overweight men, 500 mg trigonelline reduced glucose and insulin concentrations at 15 minutes after an oral glucose challenge versus placebo, but did not change the 2-hour glucose or insulin area under the curve. The finding is acute, small-sample evidence and should not be presented as diabetes treatment efficacy.

Citation: van Dijk et al., Diabetes Care 32 (2009), 1023–1025. PMID: 19324944.View source

4. Human Oral Pharmacokinetics

A single-dose human pharmacokinetic study found rapid absorption of trigonelline, with a reported median time to peak concentration of about 1 hour and a two-compartment disposition model. This supports oral dosage-form development, while the study was designed primarily to validate bioanalysis and pharmacokinetics rather than long-term efficacy or safety.

Citation: Jafari et al., Nanomedicine (Lond.) 16 (2021), pharmacokinetic study. PMID: 33501838.View source

Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.

Why Choose PathGene

Direct China manufacturer supply — factory pricing, no middleman
Recent-batch COA & batch traceability
In-house R&D + synthetic biology / enzymatic production platform
Free sample for qualified B2B buyers before commercial order
Flexible MOQ — from lab-scale trial to ton-scale commercial supply
One-stop OEM/private-label support for finished dosage forms
Worldwide shipping by courier, air freight, and sea freight

OEM & Private-Label Services

·Custom capsule manufacturing
·Custom tablet manufacturing
·Powder blending & custom formulation
·Private-label bottles, pouches & labels
·Small trial orders
·Bulk commercial production
·Export documentation
·Third-party laboratory testing

Documents Available

·Product specification sheet — request from sales
·Recent-batch COA — confirm by product and batch
·Other quality documents — confirm by product and batch

Documents are subject to product and batch availability; third-party reports are provided only when applicable.

Quality documents

Review specifications first, then batch data at shipment

The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.