1. Chemical identity reference
Public chemical databases list Calcium β-Hydroxy-β-Methylbutyrate under the stated identity; this reference supports identity review and does not replace the batch COA.
Citation: PubChem compound recordView source
Sample Available
HMB-Ca
CAS 135236-72-5
Calcium β-Hydroxy-β-Methylbutyrate Powder
HMB / Total Assay≥84% HMB; ≥99% total
Calcium HMB powder for sports-nutrition blends, with HMB and calcium content evaluated separately
Calcium β-Hydroxy-β-Methylbutyrate Powder (CAS 135236-72-5), specification ≥84% HMB; ≥99% total. Calcium HMB for sports-nutrition ingredient evaluation, with separate ≥84% HMB-content and ≥99% total-assay specifications. Batch COA and evaluation samples are available. MOQ: 1 kg. healthy-aging ingredients
Quote / sample & deliveryMW292.34 g/mol (COA hydrate form)
Key Specifications
| Product Positioning | Calcium HMB powder for sports-nutrition blends, with HMB and calcium content evaluated separately |
| Application Scenarios | sports nutrition research · mineral premix development · oral solid-dose screening |
| CAS Number | 135236-72-5 |
| HMB / Total Assay | ≥84% HMB; ≥99% total |
| Molecular Formula | C10H20CaO7 |
| Molecular Weight | 292.34 g/mol (COA hydrate form) |
| Appearance | White crystalline powder |
| Solubility | Soluble in water; confirm concentration and pH in final format |
| Storage | Sealed, cool, dry and protected from light |
| Shelf Life | 2 years |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
HMB / Total Assay ≥84% HMB; ≥99% totalCAS 135236-72-5
MOQ1 kg
Lead Time3–5 business days, subject to qualification
Packaging1 g / 100 g / 1 kg / 25 kg
Free sample available
View quality documents ↓What Is HMB-Ca?
Calcium HMB is the calcium salt of beta-hydroxy-beta-methylbutyric acid. The supplied COA reports both HMB content and calcium contribution, which should be kept separate when comparing grades or calculating formulations. Do not assume direct equivalence. Calcium HMB includes calcium and may be specified with a particular hydration basis. Calculate the HMB contribution from the agreed assay rather than the total powder mass. Product image: AI-generated ingredient illustration; actual batch appearance is subject to the sample and COA.
Other Names
Calcium HMBCaHMBCalcium 3-hydroxy-3-methylbutyrateCAS 135236-72-5
Key Features
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Calcium HMB Bulk Supply
PathGene supplies Calcium HMB, CAS 135236-72-5, with specification ≥84% HMB; ≥99% total.
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Separate HMB and Total Content
HMB-Ca with separate HMB-content and total-assay specifications for ingredient projects.
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Batch Quality Documentation
Batch COA supports the quality evaluation of Calcium HMB and the agreed purchasing specification.
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Evaluation Samples
Request Calcium HMB samples for incoming-quality evaluation and project trials.
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Supply and Packaging
MOQ: 1 kg. Packaging options: 1 g, 100 g, 1 kg, 25 kg.
Recent batch test data
Test items, specifications and results for the listed batch are shown here. View or request a COA in the quality documents section.
Batch No.
PGHMB-260404
Test date
2026-04-05
Specification
Q/PG-INHOUSE
Pack size
25 kg/drum
Storage
Sealed, cool, dry and protected from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| HMB purity | ≥84% | 91.45% |
| Calcium (dry basis) | 13.6–14.8% | 14.53% |
| Total content (dry basis) | ≥99.0% | 99.67% |
| Loss on drying | 5.0–7.5% | 6.21% |
| Heavy metals | ≤10 ppm | Complies |
View an available COA in the quality documents section. Check the document for its product form and batch; request a signed COA for your purchasing or shipment batch separately.
Applicable Dosage Forms
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
Calcium HMB development essentials
HMB ≥84% and total assay ≥99% are different measures; calculate HMB-moiety loading separately from calcium-salt mass.
91.45%
HMB purity
99.67%
Total content (dry basis)
PGHMB-260404 · Results apply to this lot; interpret purity, assay and water on their respective bases.
- Composition candidates:
- Premix HMB before adding whey protein in sachets; screen fillers and disintegrants for tablets, and assay creatine combinations separately.
- Processing priorities:
- Assess density-driven segregation with bulk protein; check reconstitution, sedimentation and flavour, with separate acid–base testing for effervescent formats.
- Testing priorities:
- HMB assay, calcium, hydration state, uniformity, reconstitution and stored assay.
Calcium HMB formulation development: composition, processing and validation
Composition candidates, processing sequences and tests support pilot design. Confirm candidate excipients and processes using this material in the actual finished formulation.
Solid formats: carriers, loading and mixing
- At a hypothetical confirmed 84.0% HMB-moiety mass assay, 100 g HMB moiety requires 100 / 0.84 = 119.05 g ingredient. Calcium-salt targets use the salt assay separately; do not substitute 99% total assay for the 84% HMB measure.
- Premix HMB before adding whey protein in sachets; screen fillers and disintegrants for tablets, and assay creatine combinations separately.
- Record ingredient lots, actual component masses, loading bases and addition sequence, retaining blanks and single-ingredient controls for traceable changes.
Processing and formats: pilot batches through filling
- Assess density-driven segregation with bulk protein; check reconstitution, sedimentation and flavour, with separate acid–base testing for effervescent formats.
- Select blending/filling equipment for the actual format, recording size, bulk density, mixing time and fill mass; liquid or softgel routes need separate carrier, sedimentation and container/shell compatibility testing.
Validation and scale-up: tests, retained samples and packaging
- HMB assay, calcium, hydration state, uniformity, reconstitution and stored assay.
- Sample upper/middle/lower positions and start/middle/end filling; compare with ingredients, process blanks and single-ingredient results, documenting deviations and corrections.
- Include actual packaging, transport and intended storage in retained-sample plans; ingredient COAs and storage conditions do not establish a new finished-product shelf life.
Research combinations and formulation directions
Study combinations, individual-ingredient mechanisms and product precedents are distinguished; expand each entry for scope and pilot-development checks.
Human combination studyCalcium HMB + whey protein: combination research with training
The cited trial compared whey-protein regimens with calcium HMB during 12 weeks of resistance training, observing changes in some regional measures. Develop premixing, HMB equivalents and reconstitution without generalizing regional findings to whole-body benefits in all populations.
Expand research and formulation notes +Collapse research and formulation notes −
Development rationale: The cited trial compared whey-protein regimens with calcium HMB during 12 weeks of resistance training, observing changes in some regional measures. Develop premixing, HMB equivalents and reconstitution without generalizing regional findings to whole-body benefits in all populations.
Evidence scope: The cited trial compared whey-protein regimens with calcium HMB during 12 weeks of resistance training, observing changes in some regional measures. Develop premixing, HMB equivalents and reconstitution without generalizing regional findings to whole-body benefits in all populations.
Pilot checks: Premix low-level ingredients before bulk powders; record size/density differences and test segregation, fill mass and reconstitution sensory properties.
2020 · Combined protein and calcium β-hydroxy-β-methylbutyrate induced gains in leg fat free mass: a double-blinded, placebo-controlled study. ↗Literature-Supported Research Directions
Scientific Research
2. Calcium-HMB and acute muscle protein turnover
A tracer-based study in eight healthy young men measured muscle protein synthesis and breakdown after calcium-HMB. The authors observed acute changes in these physiological measurements. The small mechanistic study does not predict long-term outcomes for every population or a finished formulation.
Citation: Wilkinson et al. British Journal of Nutrition. 2018.View source
3. Resistance-training trials report mixed results
In a 12-week randomized trial among resistance-trained men with high protein intake, calcium-HMB did not outperform placebo on most measured body-composition and strength outcomes. Together with smaller mechanistic studies, this supports a cautious research summary rather than a blanket performance claim.
Citation: Tritto et al. Journal of Strength and Conditioning Research. 2019.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
1 kg
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
HMB / Total Assay & Assay Method
The stated purity and batch result are shown separately. Confirm the method, dry-basis calculation and salt or hydrate form against the current COA.
Solubility & Formulation
Formulation work should confirm concentration, pH, light, moisture and hold-time controls for Calcium β-Hydroxy-β-Methylbutyrate; suitability depends on the final format and market requirements.
What are the MOQ and pack options for calcium HMB powder?+
The raw-material MOQ for calcium HMB powder is 1 kg, with pack options of 1 g, 100 g, 1 kg, 25 kg. Price comparisons should distinguish HMB component from total assay, rather than only powder price.
Is calcium HMB equivalent to HMB free acid by weight?+
Do not assume direct equivalence. Calcium HMB includes calcium and may be specified with a particular hydration basis. Calculate the HMB contribution from the agreed assay rather than the total powder mass.
What are the HMB-content and total-assay specifications for calcium HMB?+
Calcium HMB (HMB-Ca) powder separately specifies HMB content of ≥84% and total assay of ≥99%. Review the defined method and calculation basis for each measurement. Calculate the formula’s HMB contribution from the lot’s HMB-content result, rather than substituting the total assay.
Should calcium HMB formulation quantities use powder mass or HMB content?+
When declaring the HMB component, calculate powder inclusion from the offered lot’s HMB content and specified basis. Review calcium contribution and hydration or dry-basis corrections separately. Align calculation bases before comparing cost per HMB component across salts or free-acid materials.
Why Choose PathGene
- Direct China manufacturer supply — factory pricing, no middleman
- Recent-batch COA & batch traceability
- In-house R&D + synthetic biology / enzymatic production platform
- Free sample for qualified B2B buyers before commercial order
- Flexible MOQ — from lab-scale trial to ton-scale commercial supply
- One-stop OEM/private-label support for finished dosage forms
- Worldwide shipping by courier, air freight, and sea freight
OEM & Private-Label Services
- ·Custom capsule manufacturing
- ·Custom tablet manufacturing
- ·Powder blending & custom formulation
- ·Private-label bottles, pouches & labels
- ·Small trial orders
- ·Bulk commercial production
- ·Export documentation
- ·Third-party testing support available on request
Documents Available
- ·Product specification sheet — request from sales
- ·Recent-batch COA — confirm by product and batch
- ·Other quality documents — confirm by product and batch
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
Review specifications first, then batch data at shipment
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Product specification
Stable acceptance criteria · Available on request
Recent-batch COA
Actual test data · Check the COA for the applicable batch
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