ALA
CAS 868074-65-1 / 5451-09-2
Purity≥98.0%
5-ALA phosphate and hydrochloride raw materials
PathGene supplies 5-ALA phosphate powder (CAS 868074-65-1) and 5-ALA hydrochloride powder (CAS 5451-09-2), each with a ≥98.0% purity specification. The free acid, CAS 106-60-5, identifies the parent compound. Salt-specific COAs and evaluation samples are available. MOQ: 1 kg. healthy-aging ingredients
Quote / sample & delivery
Key Specifications
| Product Positioning | 5-ALA phosphate and hydrochloride raw materials |
| Application Scenarios | porphyrin-pathway research · photodynamic formulation screening · light-sensitive biochemical systems |
| CAS Number | 868074-65-1 / 5451-09-2 |
| Purity | ≥98.0% |
| Molecular Formula | Phosphate: C5H12NO7P; HCl: C5H9NO3·HCl |
| Molecular Weight | Phosphate: 229.12 g/mol; HCl: 167.59 g/mol |
| Appearance | White crystalline powder |
| Solubility | Freely soluble in water |
| Storage | 2–8°C, protect from light |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Parent 5-aminolevulinic acid, reference CAS 106-60-5. The supplied materials are the two salts below.
Dated batch results are separate from minimum specifications. Use the assay basis for the selected salt when calculating ingredient input.
5-Aminolevulinic acid (5-ALA, parent CAS 106-60-5) is an intermediate in tetrapyrrole biosynthesis. PathGene supplies its phosphate salt (CAS 868074-65-1) and hydrochloride salt (CAS 5451-09-2) as separate powder materials. The two salts have different molecular formulas and molecular weights; compare assay and formulation input on the selected salt basis. The free-acid identifier in the historical URL does not identify either supplied salt.
Two Supplied Salt Forms
Phosphate CAS 868074-65-1 and hydrochloride CAS 5451-09-2 each have their own identity and COA.
Salt-Specific Batch Data
Phosphate batch PG5ALA-260112: 98.5%; hydrochloride batch PG5ALAH-260403: 98.3%. Both have a ≥98.0% specification.
| Molecular Formula | Phosphate: C5H12NO7P; HCl: C5H9NO3·HCl |
| Molecular Weight | Phosphate: 229.12 g/mol; HCl: 167.59 g/mol |
| Appearance | White crystalline powder |
| Solubility | Freely soluble in water |
| Storage Condition | 2–8°C, protect from light |
| Shelf Life | 24 months |
| Grade 1 | Phosphate Salt · ≥98.0% · COA |
| Grade 2 | Hydrochloride Salt · ≥98.0% · COA |
| Test Item | Specification |
|---|---|
| Phosphate purity | ≥98.0% |
| Hydrochloride purity | ≥98.0% |
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
Supply is hydrochloride or phosphate; free ALA is an identity/equivalent reference, with loading based on the selected salt COA.
Composition candidates, processing sequences and tests support pilot design. Confirm candidate excipients and processes using this material in the actual finished formulation.
Application examples follow the materials, formats and findings actually studied. Combination studies, single-ingredient studies, commercial precedents and development candidates are distinguished.
5-ALA and iron have different roles in heme synthesis. A capsule study combined 5-ALA phosphate with sodium ferrous citrate (SFC), requiring separate control of ALA salt identity, ALA reporting basis and iron source.
Show research and formulation insights +Hide details −Combination / selection rationale: 5-ALA and iron have different roles in heme synthesis. A capsule study combined 5-ALA phosphate with sodium ferrous citrate (SFC), requiring separate control of ALA salt identity, ALA reporting basis and iron source.
Published evidence / source details: The 2023 ALADDIN trial randomized 100 participants with sarcopenia to five groups for 12 weeks. Regimens used reported ALA-phosphate amounts of 50/100/150 mg and SFC amounts of 29/57 mg; all groups also received zinc yeast. The primary week-12 skeletal-muscle-mass-index endpoint did not differ significantly between groups, while some grip-strength and other secondary measures improved.
Development insights: Confirm molecular weight, assay and ALA equivalent for the actual supplied salt, then calculate SFC and elemental iron separately: SFC mass is not elemental-iron mass. Premix ALA, iron and low-level partners separately for capsule trials, assessing assay uniformity, moisture, colour, disintegration and packaged stability, with an iron-matched control.
Evidence scope: A study of a specific phosphate-based formulation, not evidence of this ingredient’s treatment effect or hydrochloride equivalence. Published amounts are not intake recommendations.
2023 · Tamura et al. · ALADDIN study · DOI 10.3390/nu15132866 ↗Literature-Supported Research Directions
5-Aminolevulinic acid is a precursor in tetrapyrrole biosynthesis. At suitable low concentrations, plant studies have linked exogenous ALA with chlorophyll accumulation, photosynthesis and growth responses; excessive exposure can produce opposite effects.
Citation: Hotta et al., Bioscience, Biotechnology, and Biochemistry (1997): ALA effects on photosynthesis, chlorophyll and plant growth.View source
Field and seedling studies have evaluated ALA for drought, salinity and oxidative-stress responses, including changes in antioxidant enzymes, photosynthetic parameters and ion distribution. Crop, dose and application method must be validated separately.
Citation: Mohammadi et al., Scientific Reports (2023); Wu et al., Frontiers in Plant Science (2021).View source
ALA can be evaluated in foliar-spray, seedling-treatment and nutrient-assisted agricultural formulations. Compatibility, light stability, crop safety and concentration-response windows are essential development parameters.
Citation: Hotta et al., Bioscience, Biotechnology, and Biochemistry (1997).View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
1 kg
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Insulated Box + Carton
For products requiring temperature-controlled transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Strain Engineering & Seed Culture
A production microorganism (typically E. coli or yeast) engineered to overexpress 5-aminolevulinic acid synthase and related pathway enzymes is revived and expanded through seed culture stages to build sufficient healthy biomass.
Fed-Batch Fermentation
Seed culture is transferred into production bioreactors where temperature, pH, dissolved oxygen, and feeding of carbon source and precursors (e.g., glycine) are tightly controlled to drive enzymatic conversion into 5-ALA via the biosynthetic pathway.
Broth Clarification
Fermentation broth is harvested and cell biomass is removed by centrifugation and/or microfiltration, yielding a clarified liquid containing dissolved 5-ALA.
Chromatographic Capture & Decolorization
The clarified broth is passed through ion-exchange resin to selectively capture 5-ALA, followed by decolorization steps to remove pigments and fermentation by-products.
Concentration & Crystallization
The purified 5-ALA solution is concentrated under controlled conditions and induced to crystallize, producing a defined crystal form suited for stable bulk handling.
Drying & Milling
Crystals are separated, dried under low-temperature and light-protected conditions to minimize degradation, and milled/sieved to achieve the target particle size and uniform white powder form.
Quality Testing
Each batch undergoes HPLC assay, appearance, moisture, heavy metals, and microbial testing against internal and pharmacopoeia-referenced specifications before release.
Packaging & Storage
Finished 5-ALA is packed in moisture-proof, light-protective containers under inert or desiccant-controlled conditions and stored/shipped cold or ambient with recommended cool, dry, dark storage to preserve stability.
Each supplied salt has a ≥98.0% purity specification. Phosphate and hydrochloride require their own COA, molecular-weight basis and analytical documentation; neither is supplied as the free acid.
5-ALA is freely soluble in water, allowing straightforward incorporation into aqueous solutions, drops, and beverage-type formats. Because the compound is sensitive to heat, light, and elevated pH — conditions that can promote self-condensation into pyrazine-type degradation products — formulators are advised to work in mildly acidic aqueous systems, minimize prolonged heat exposure during processing, and protect finished formulations from light. For solid dosage forms (capsules, tablets) and agricultural foliar sprays, compatibility testing with excipients or tank-mix partners is recommended to confirm stability under intended storage and use conditions.
5-ALA phosphate (CAS 868074-65-1) and hydrochloride (CAS 5451-09-2), each specified at ≥98.0%. The parent free-acid CAS is 106-60-5.
5-ALA phosphate (CAS 868074-65-1) and hydrochloride (CAS 5451-09-2) are separate supplied salts, each with a purity specification of ≥98.0%. Match molecular weight, assay basis and batch COA to the ordered salt. Parent free-acid CAS 106-60-5 is an identity reference, not the identity of either supplied salt.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Check the COA for the applicable batch
Technical Resources
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