Ubiquinol
CAS 1093-61-2
Purity≥98.0%
Reduced coenzyme Q10 for lipid-based nutrition formulations
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Confirm reduced CoQ10 ratio and oxidation-protection packaging.
Key Specifications
| Product Positioning | Reduced coenzyme Q10 for lipid-based nutrition formulations |
| Application Scenarios | lipid-based softgels · coenzyme Q redox research · emulsion stability screening |
| CAS Number | 1093-61-2 |
| Purity | ≥98.0% |
| Molecular Formula | C₅₉H₉₂O₄ |
| Molecular Weight | 881.38 g/mol |
| Appearance | Yellow to orange viscous oil or waxy solid |
| Solubility | Soluble in organic solvents |
| Storage | 2–8°C, inert atmosphere, protect from light |
| Shelf Life | 18 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Ubiquinol (reduced Coenzyme Q10) is the fully reduced, hydroquinone form of Coenzyme Q10, a lipid-soluble benzoquinone derivative present in the mitochondrial electron transport chain of virtually all human and animal cells. It belongs to the ubiquinone/prenylquinone chemical class, with molecular formula C59H92O4 and molecular weight of approximately 881.38 g/mol, carrying the long decaprenyl isoprenoid side chain characteristic of the CoQ10 homolog series. In vivo, ubiquinol continuously interconverts with its oxidized counterpart, ubiquinone, through cellular redox cycling. Commercial bulk ubiquinol is generally not extracted from natural sources at scale; it is manufactured by fermenting an engineered microbial strain to biosynthesize the CoQ10 quinone backbone, then applying a controlled enzymatic/biocatalytic reduction step to convert the oxidized quinone into the reduced hydroquinone, followed by purification and stabilization under an inert atmosphere.
HPLC-Verified High Purity
Assayed at ≥98.0% purity by validated HPLC methods, with tight control over residual ubiquinone (oxidized form) content to ensure the material stays in its reduced, bioactive state.
Fermentation & Enzymatic Reduction Platform
Produced on a synthetic biology and enzymatic conversion platform: an engineered fermentation strain biosynthesizes the CoQ10 backbone, which is then selectively reduced to ubiquinol under biocatalytic control rather than harsh chemical reducing agents.
Stable Oil / Waxy Solid Form
Supplied as a yellow to orange viscous oil or waxy solid, packaged and stored under inert, light-protected conditions to minimize oxidation back to ubiquinone during transport and storage.
Full Contaminant Screening
Every batch is screened for heavy metals (Pb, Hg, Cd, As), residual solvents, and microbial limits (total plate count, yeast/mold, E. coli, Salmonella) to support food, dietary supplement, and pharma-grade applications.
Flexible Bulk & OEM Supply
Available in bulk drums or nitrogen-flushed containers with customizable packaging sizes, plus OEM/private-label formulation support (softgels, powders on carrier, blends) for supplement and functional-food brands.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGUBI-260612
Test date
Specification
In-house
Pack size
25kg/carton
Storage
2–8°C, inert atmosphere, protect from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | Yellow to orange viscous oil or waxy solid | Conforms |
| Odor/Color | Characteristic, no abnormal odor | Conforms |
| Assay (HPLC) | ≥98.0% | 98.6% |
| Ubiquinone (oxidized form) content | ≤2.0% | 1.1% |
| Single maximum impurity | ≤0.5% | 0.3% |
| Loss on drying | ≤0.5% | 0.2% |
| Residue on ignition (sulfated ash) | ≤0.2% | 0.08% |
| Lead (Pb) | ≤1.0 mg/kg | <0.5 mg/kg |
| Mercury (Hg) | ≤0.1 mg/kg | <0.1 mg/kg |
| Cadmium (Cd) | ≤0.3 mg/kg | <0.1 mg/kg |
| Arsenic (As) | ≤1.0 mg/kg | <0.5 mg/kg |
| Total plate count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & mold count | ≤100 CFU/g | <10 CFU/g |
| E. coli / Salmonella | Negative/25 g | Negative |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Softgels
The combination is used in mitochondrial and cognitive-health formulations: ubiquinol participates in electron transport and lipid-phase antioxidant protection, while PQQ is studied through distinct redox and mitochondrial-signaling pathways.
Evidence: A human study has evaluated PQQ alone and with CoQ10, but direct evidence specific to every ubiquinol formulation remains limited; treat this as a research-backed concept rather than guaranteed synergy.Source
Both are suited to oil-based softgels, enabling a compact lipid-nutrition format. Development should focus on oxidative stability, carrier oils, dissolved-state retention and sensory control.
Evidence: Formulation and complementary-nutrition rationale; no direct clinical trial proving ubiquinol–omega-3 synergy was identified.Source
Literature-Supported Research Directions
A small crossover study in 12 healthy volunteers using matched softgel excipients reported higher steady-state plasma CoQ10 after ubiquinol than ubiquinone. The sample was small and formulation strongly affects CoQ10 absorption, so the result should not be generalized to every finished product.
Citation: Langsjoen & Langsjoen, Clinical Pharmacology in Drug Development 3 (2014), 13–17. DOI: 10.1002/cpdd.73.View source
In a randomized double-blind trial, 48 completers receiving 100 or 200 mg/day ubiquinol for eight weeks showed improved brachial-artery flow-mediated dilation versus placebo, together with increased plasma CoQ10. This was a single-center biomarker trial, not a cardiovascular-event study.
Citation: Raitakari et al., Nutrients 12 (2020), 1098. PMID: 32326664.View source
A 12-week double-blind placebo-controlled study tested 100 or 150 mg/day ubiquinol in otherwise healthy adults with persistent mild fatigue. Serum ubiquinol rose three- to four-fold and several fatigue measures improved, but the modest sample and subjective endpoints require independent confirmation.
Citation: Mizuno et al., Nutrients 12 (2020), 1640. DOI: 10.3390/nu12061640.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
1 kg
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Insulated Box + Carton
For products requiring temperature-controlled transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Strain fermentation
An engineered, high-yield microbial production strain is cultured under fed-batch fermentation conditions to biosynthesize the oxidized CoQ10 (ubiquinone) quinone backbone intracellularly.
Cell harvest and disruption
Fermentation broth is harvested by centrifugation, and cell walls are disrupted to release intracellular CoQ10 for downstream recovery.
Solvent extraction of crude ubiquinone
Crude oxidized CoQ10 is extracted from the disrupted biomass using food-grade organic solvents, then concentrated to remove cell debris and residual media components.
Enzymatic/biocatalytic reduction
Purified oxidized CoQ10 undergoes a controlled enzymatic reduction step under an inert (oxygen-free) atmosphere, converting the quinone to the reduced hydroquinone (ubiquinol) form with high selectivity and minimal over-reduction byproducts.
Purification and crystallization
The reduced product is purified through liquid-liquid extraction, chromatographic polishing, and controlled crystallization under nitrogen protection to separate ubiquinol from unreacted starting material and byproducts.
Drying and stabilization
Purified ubiquinol is dried and, where required, blended with approved antioxidant stabilizers under low-light, low-oxygen conditions to preserve its reduced state.
Quality control testing
Each batch is tested for assay/purity, residual ubiquinone content, heavy metals, residual solvents, and microbial limits before release.
Inert packaging and storage
Finished material is packed under nitrogen flush in light-protected, sealed containers and stored under cool, dry, oxygen-limited conditions to maintain shelf-life stability.
Purity is determined by validated reversed-phase HPLC with UV or electrochemical detection, quantifying both ubiquinol content and residual oxidized ubiquinone to confirm the material remains predominantly in its reduced state. Buyers should request the certificate of analysis (CoA) for each lot, confirm the HPLC method and reference standard used, and verify storage/transport conditions (nitrogen-flushed, light-protected, cold-chain where applicable), since ubiquinol purity can drift toward ubiquinone over time if oxygen or light exposure is not controlled.
Ubiquinol is lipophilic and oxidation-sensitive; current commercial products are predominantly oil-based softgels. Develop under oxygen- and light-controlled conditions and verify oil-carrier compatibility, dissolved-state retention, antioxidant protection and shelf-life conversion to ubiquinone.
Purity is verified by validated HPLC methods on every production batch. A certificate of analysis (CoA) listing assay, residual ubiquinone content, heavy metals, and microbial results is available for each lot upon request.
It is produced on our synthetic biology and enzymatic conversion platform: a microbial fermentation step biosynthesizes the CoQ10 backbone, followed by a controlled enzymatic/biocatalytic reduction to convert it into the reduced (ubiquinol) form, avoiding harsh chemical reducing agents.
It is soluble in organic solvents and oils but not water. It is typically formulated in lipid/oil bases, adsorbed onto a carrier for powder blends, or emulsified for liquid/softgel formats; light- and oxygen-protective processing is recommended.
Yes, small evaluation samples are generally available on request so you can verify purity, appearance, and compatibility with your formulation before committing to a bulk order.
Yes, buyers are welcome to send incoming shipments for third-party laboratory testing, and we can coordinate on shared reference standards or methods if needed for cross-verification.
Yes, we support OEM/private-label programs, including custom formulation (softgels, powders, blends), packaging design, and labeling to your brand specifications.
Standard packaging includes nitrogen-flushed, light-protected containers/drums in various sizes; cold-chain shipping can be arranged for larger or temperature-sensitive orders.
MOQ varies by packaging format and order volume; please contact our sales team with your target quantity, application, and destination to receive a tailored quotation and lead time.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
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