Ubiquinol
Ubiquinol (Reduced CoQ10)
Key Specifications
| CAS Number | 1093-61-2 |
| Purity | ≥98.0% |
| Molecular Formula | C₅₉H₉₂O₄ |
| Molecular Weight | 881.38 g/mol |
| Appearance | Yellow to orange viscous oil or waxy solid |
| Solubility | Soluble in organic solvents |
| Storage | 2–8°C, inert atmosphere, protect from light |
| Shelf Life | 18 months |
CAS 1093-61-2
What Is Ubiquinol?
Ubiquinol (reduced Coenzyme Q10) is the fully reduced, hydroquinone form of Coenzyme Q10, a lipid-soluble benzoquinone derivative present in the mitochondrial electron transport chain of virtually all human and animal cells. It belongs to the ubiquinone/prenylquinone chemical class, with molecular formula C59H92O4 and molecular weight of approximately 881.38 g/mol, carrying the long decaprenyl isoprenoid side chain characteristic of the CoQ10 homolog series. In vivo, ubiquinol continuously interconverts with its oxidized counterpart, ubiquinone, through cellular redox cycling. Commercial bulk ubiquinol is generally not extracted from natural sources at scale; it is manufactured by fermenting an engineered microbial strain to biosynthesize the CoQ10 quinone backbone, then applying a controlled enzymatic/biocatalytic reduction step to convert the oxidized quinone into the reduced hydroquinone, followed by purification and stabilization under an inert atmosphere.
Other Names
Key Features
HPLC-Verified High Purity
Assayed at ≥98.0% purity by validated HPLC methods, with tight control over residual ubiquinone (oxidized form) content to ensure the material stays in its reduced, bioactive state.
Fermentation & Enzymatic Reduction Platform
Produced on a synthetic biology and enzymatic conversion platform: an engineered fermentation strain biosynthesizes the CoQ10 backbone, which is then selectively reduced to ubiquinol under biocatalytic control rather than harsh chemical reducing agents.
Stable Oil / Waxy Solid Form
Supplied as a yellow to orange viscous oil or waxy solid, packaged and stored under inert, light-protected conditions to minimize oxidation back to ubiquinone during transport and storage.
Full Contaminant Screening
Every batch is screened for heavy metals (Pb, Hg, Cd, As), residual solvents, and microbial limits (total plate count, yeast/mold, E. coli, Salmonella) to support food, dietary supplement, and pharma-grade applications.
Flexible Bulk & OEM Supply
Available in bulk drums or nitrogen-flushed containers with customizable packaging sizes, plus OEM/private-label formulation support (softgels, powders on carrier, blends) for supplement and functional-food brands.
| Molecular Formula | C₅₉H₉₂O₄ |
| Molecular Weight | 881.38 g/mol |
| Appearance | Yellow to orange viscous oil or waxy solid |
| Solubility | Soluble in organic solvents |
| Storage Condition | 2–8°C, inert atmosphere, protect from light |
| Shelf Life | 18 months |
| Grade 1 | Supplement Grade · ≥98.0% · COA |
End-Product Applications
Mechanism & Benefits
Antioxidant, cardiac muscle protection, cellular energy enhancement. Superior bioavailability vs. ubiquinone.
Packaging Options
1 kg 5 kg 10 kg
Lead Time
7–10 business days
Minimum Order
1 kg
Custom Packaging
Custom packaging (foil bags, HDPE drums), GMP labeling, and export documentation are available. Contact us for specifics.Certifications
ISO
ISO
Manufacturing Process
Strain fermentation
An engineered, high-yield microbial production strain is cultured under fed-batch fermentation conditions to biosynthesize the oxidized CoQ10 (ubiquinone) quinone backbone intracellularly.
Cell harvest and disruption
Fermentation broth is harvested by centrifugation, and cell walls are disrupted to release intracellular CoQ10 for downstream recovery.
Solvent extraction of crude ubiquinone
Crude oxidized CoQ10 is extracted from the disrupted biomass using food-grade organic solvents, then concentrated to remove cell debris and residual media components.
Enzymatic/biocatalytic reduction
Purified oxidized CoQ10 undergoes a controlled enzymatic reduction step under an inert (oxygen-free) atmosphere, converting the quinone to the reduced hydroquinone (ubiquinol) form with high selectivity and minimal over-reduction byproducts.
Purification and crystallization
The reduced product is purified through liquid-liquid extraction, chromatographic polishing, and controlled crystallization under nitrogen protection to separate ubiquinol from unreacted starting material and byproducts.
Drying and stabilization
Purified ubiquinol is dried and, where required, blended with approved antioxidant stabilizers under low-light, low-oxygen conditions to preserve its reduced state.
Quality control testing
Each batch is tested for assay/purity, residual ubiquinone content, heavy metals, residual solvents, and microbial limits before release.
Inert packaging and storage
Finished material is packed under nitrogen flush in light-protected, sealed containers and stored under cool, dry, oxygen-limited conditions to maintain shelf-life stability.
Quality Specifications
| Test Item | Specification | Result |
|---|---|---|
| Appearance | Yellow to orange viscous oil or waxy solid | Conforms |
| Odor/Color | Characteristic, no abnormal odor | Conforms |
| Assay (HPLC) | ≥98.0% | 98.6% |
| Ubiquinone (oxidized form) content | ≤2.0% | 1.1% |
| Single maximum impurity | ≤0.5% | 0.3% |
| Loss on drying | ≤0.5% | 0.2% |
| Residue on ignition (sulfated ash) | ≤0.2% | 0.08% |
| Lead (Pb) | ≤1.0 mg/kg | <0.5 mg/kg |
| Mercury (Hg) | ≤0.1 mg/kg | <0.1 mg/kg |
| Cadmium (Cd) | ≤0.3 mg/kg | <0.1 mg/kg |
| Arsenic (As) | ≤1.0 mg/kg | <0.5 mg/kg |
| Total plate count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & mold count | ≤100 CFU/g | <10 CFU/g |
| E. coli / Salmonella | Negative/25 g | Negative |
Purity & Assay Method
Purity is determined by validated reversed-phase HPLC with UV or electrochemical detection, quantifying both ubiquinol content and residual oxidized ubiquinone to confirm the material remains predominantly in its reduced state. Buyers should request the certificate of analysis (CoA) for each lot, confirm the HPLC method and reference standard used, and verify storage/transport conditions (nitrogen-flushed, light-protected, cold-chain where applicable), since ubiquinol purity can drift toward ubiquinone over time if oxygen or light exposure is not controlled.
Solubility & Formulation
Ubiquinol is soluble in organic solvents (e.g., ethanol, oils, and lipid carriers) but practically insoluble in water, consistent with its lipophilic isoprenoid side chain. For finished-product formulation, it is typically dissolved or dispersed in a lipid/oil base (such as MCT oil or soybean oil), micronized and adsorbed onto a food-grade carrier for powder blends, or emulsified/solubilized for liquid and softgel delivery formats. Because ubiquinol is oxygen- and light-sensitive, formulators should use appropriately deoxygenated processing, opaque or amber packaging, and consider co-formulating with compatible antioxidants to maintain the reduced-form ratio through shelf life.
Available Product Forms
Bulk Ubiquinol Powder
High-purity raw powder for supplement factories, research organizations, ingredient distributors, and contract manufacturers.
Ubiquinol Capsules
Custom capsule strength, shell material, bottle count, excipients, and label design for private-label brands.
Ubiquinol Tablets
Tablet formulation, granulation, compression, coating, bottle packaging, and custom labeling support.
Ubiquinol Powder Blends
Ubiquinol can be blended with complementary actives (antioxidants, other longevity ingredients, vitamins, minerals) per customer formula.
How is the ≥98.0% purity confirmed, and can I request a batch-specific CoA?+
Purity is verified by validated HPLC methods on every production batch. A certificate of analysis (CoA) listing assay, residual ubiquinone content, heavy metals, and microbial results is available for each lot upon request.
How is this ubiquinol produced — is it fermentation-based or chemically synthesized?+
It is produced on our synthetic biology and enzymatic conversion platform: a microbial fermentation step biosynthesizes the CoQ10 backbone, followed by a controlled enzymatic/biocatalytic reduction to convert it into the reduced (ubiquinol) form, avoiding harsh chemical reducing agents.
What is the solubility of this material, and how should I formulate with it?+
It is soluble in organic solvents and oils but not water. It is typically formulated in lipid/oil bases, adsorbed onto a carrier for powder blends, or emulsified for liquid/softgel formats; light- and oxygen-protective processing is recommended.
Can I request a free sample before placing a bulk order?+
Yes, small evaluation samples are generally available on request so you can verify purity, appearance, and compatibility with your formulation before committing to a bulk order.
Do you support independent third-party testing of shipments?+
Yes, buyers are welcome to send incoming shipments for third-party laboratory testing, and we can coordinate on shared reference standards or methods if needed for cross-verification.
Do you offer OEM or private-label supply for finished dietary supplement products?+
Yes, we support OEM/private-label programs, including custom formulation (softgels, powders, blends), packaging design, and labeling to your brand specifications.
What packaging options are available, and how is the material protected from oxidation during shipping?+
Standard packaging includes nitrogen-flushed, light-protected containers/drums in various sizes; cold-chain shipping can be arranged for larger or temperature-sensitive orders.
What is the MOQ, and how can I get a quotation?+
MOQ varies by packaging format and order volume; please contact our sales team with your target quantity, application, and destination to receive a tailored quotation and lead time.
Why Choose PathGene
- Direct China manufacturer supply — factory pricing, no middleman
- Batch-specific COA & full traceability on every shipment
- In-house R&D + synthetic biology / enzymatic production platform
- Free sample for qualified B2B buyers before commercial order
- Flexible MOQ — from lab-scale trial to ton-scale commercial supply
- One-stop OEM/private-label support for finished dosage forms
- Worldwide shipping by courier, air freight, and sea freight
OEM & Private-Label Services
- ·Custom capsule manufacturing
- ·Custom tablet manufacturing
- ·Powder blending & custom formulation
- ·Private-label bottles, pouches & labels
- ·Small trial orders
- ·Bulk commercial production
- ·Export documentation
- ·Third-party laboratory testing
Documents Available
- ·Certificate of Analysis (COA)
- ·Product specification sheet
- ·Material Safety Data Sheet (MSDS)
- ·Manufacturing flow chart
- ·HPLC test report
- ·Heavy-metal test report
- ·Microbiological test report
- ·Non-GMO / allergen statement
- ·Country-of-origin documentation
- ·Packing list & commercial invoice
Certificate availability should be confirmed with our sales team before ordering.
Sample Certificate of Analysis
PathGene Biotech Co., Ltd.
南京派琪生物科技有限公司
CERTIFICATE OF ANALYSIS
Layout example — not an issued batch record
Product Name
Ubiquinol
CAS No.
1093-61-2
Batch No.
PG-SAMPLE-000000
Packaging
Issued upon order confirmation
| Test Item | Specification | Result |
|---|---|---|
| Appearance | Yellow to orange viscous oil or waxy solid | Conforms |
| Odor/Color | Characteristic, no abnormal odor | Conforms |
| Assay (HPLC) | ≥98.0% | 98.6% |
| Ubiquinone (oxidized form) content | ≤2.0% | 1.1% |
| Single maximum impurity | ≤0.5% | 0.3% |
| Loss on drying | ≤0.5% | 0.2% |
| Residue on ignition (sulfated ash) | ≤0.2% | 0.08% |
| Lead (Pb) | ≤1.0 mg/kg | <0.5 mg/kg |
| Mercury (Hg) | ≤0.1 mg/kg | <0.1 mg/kg |
| Cadmium (Cd) | ≤0.3 mg/kg | <0.1 mg/kg |
| Arsenic (As) | ≤1.0 mg/kg | <0.5 mg/kg |
| Total plate count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & mold count | ≤100 CFU/g | <10 CFU/g |
| E. coli / Salmonella | Negative/25 g | Negative |
Conclusion: Conforms to internal quality specifications
The COA issued with your order will carry the actual batch number, manufacture/test dates, and QC signature.
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