DHB
CAS 101-51-3
Purity≥98.0%
Berberine derivative for metabolic-nutrition formulation research
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore nutrition & functional ingredients.
Confirm dihydroberberine identity and controls for oxidation products and stability.
Key Specifications
| Product Positioning | Berberine derivative for metabolic-nutrition formulation research |
| Application Scenarios | alkaloid absorption research · metabolic-nutrition formulas · capsule compatibility screening |
| CAS Number | 101-51-3 |
| Purity | ≥98.0% |
| Molecular Formula | C₂₀H₁₉NO₄ |
| Molecular Weight | 337.37 g/mol |
| Appearance | Yellow crystalline powder |
| Solubility | Slightly soluble in water; soluble in ethanol |
| Storage | Room temperature, protect from light |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Dihydroberberine (DHB, CAS 101-51-3) is a reduced isoquinoline alkaloid derivative of berberine, with molecular formula C20H19NO4 and molecular weight 337.37 g/mol. Catalytic reduction converts the quaternary iminium (C=N+) of berberine into a tertiary enamine, lowering polarity and increasing lipophilicity relative to the parent alkaloid. Trace amounts occur naturally in berberine-containing botanicals such as Coptis chinensis (Huanglian), Phellodendron amurense, and Berberis species, and it can also form transiently when gut bacteria reduce ingested berberine. Commercial bulk material is typically manufactured semi-synthetically: berberine is first extracted and purified from selected plant biomass, then subjected to a controlled catalytic hydrogenation step that yields dihydroberberine, which is crystallized and dried into a stable yellow crystalline powder suitable for dietary supplement and nutraceutical formulation.
High-Purity Assay
Purity ≥98.0% verified by HPLC against a qualified reference standard, batch-to-batch consistent for demanding formulation needs.
Controlled Semi-Synthesis
Produced from selected berberine-rich plant feedstock through a tightly controlled catalytic reduction step, ensuring reaction consistency and traceability from raw material to finished powder.
Uniform Yellow Crystalline Form
Supplied as a free-flowing yellow crystalline powder with controlled particle size for consistent dosing, blending, and capsule/tablet processing.
Full Contaminant Screening
Every batch is screened for heavy metals (Pb, Hg, Cd, As), residual solvents, and microbial limits, with a full Certificate of Analysis provided.
Flexible Bulk & OEM Supply
Available in flexible order quantities from sample to bulk drums, with OEM/private-label formulation, custom packaging, and documentation support.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGDHB-260110
Test date
2026-01-12
Specification
In-house
Pack size
25kg/carton
Storage
Room temperature, protect from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | Yellow crystalline powder | Conforms |
| Odor | Characteristic, no foreign odor | Conforms |
| Identification (HPLC retention time) | Consistent with reference standard | Conforms |
| Assay (HPLC) | ≥98.0% | 98.4% |
| Loss on Drying | ≤0.5% | 0.3% |
| Heavy Metals (Pb) | ≤10 ppm | <5 ppm |
| Mercury (Hg) | ≤1 ppm | <0.5 ppm |
| Cadmium (Cd) | ≤1 ppm | <0.5 ppm |
| Arsenic (As) | ≤2 ppm | <1 ppm |
| Particle Size (through 80 mesh) | ≥95% | 98% |
| Total Plate Count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mold | ≤100 CFU/g | <10 CFU/g |
| E. coli | Negative/25 g | Negative |
| Salmonella | Negative/25 g | Negative |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
Gut microbiota and berberine metabolism provide a rationale for evaluating dihydroberberine with probiotic or fiber systems. Current human evidence is stronger for berberine or dihydroberberine alone than for this exact combination.
Evidence: Indirect evidence: a randomized study evaluated berberine with Bifidobacterium; it should not be presented as direct proof for dihydroberberine synergy.Source
Literature-Supported Research Directions
Dihydroberberine supports research into berberine metabolism, AMPK signaling and glucose/insulin responses. An initial human crossover study mainly showed exposure differences and does not establish a consistent clinical glucose-lowering effect.
Citation: Moon et al., Nutrients (2022), randomized crossover study of berberine and dihydroberberine absorption kinetics.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
100 g
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Botanical Raw Material Selection
Berberine-rich botanical material (e.g., Coptis chinensis rhizome or Phellodendron amurense bark) is sourced and screened for berberine content prior to processing.
Extraction of Berberine
The plant material is extracted using acidified aqueous or ethanol-based solvent systems to solubilize the berberine alkaloid fraction.
Purification to Berberine Intermediate
Crude extract is purified via crystallization and/or ion-exchange processing to obtain a pharmaceutical-grade berberine salt (e.g., berberine hydrochloride) intermediate.
Catalytic Reduction (Hydrogenation)
The purified berberine salt is reacted with a hydrogen donor (hydrogen gas, or agents such as ammonium formate/isopropanol) over a supported metal catalyst (e.g., Pd/C or Raney nickel) under mildly alkaline, temperature-controlled conditions, converting the quaternary iminium of berberine into the dihydro (tertiary enamine) form.
Catalyst Removal & Neutralization
The reaction mixture is filtered to remove the metal catalyst and neutralized to precipitate the dihydroberberine free base.
Crystallization
Controlled cooling and/or anti-solvent crystallization yields dihydroberberine as a defined yellow crystalline solid.
Washing, Drying & Milling
Crystals are washed to remove residual salts and mother liquor, vacuum-dried to target moisture/loss-on-drying, then milled and sieved for uniform particle size.
Quality Control & Packaging
Finished material undergoes HPLC assay, heavy metal, residual solvent, and microbial testing before being packaged under light- and moisture-protected conditions.
Purity is determined by reverse-phase HPLC with UV detection, quantified against a qualified dihydroberberine reference standard and reported on an as-is basis. Because dihydroberberine can be air- and light-sensitive and may partially reoxidize toward berberine under poor storage conditions, buyers should confirm the assay method, reference standard traceability, and related-substance/impurity profile on the batch-specific Certificate of Analysis before formulation, and request re-test data for material held longer than the recommended retest interval.
Dihydroberberine is slightly soluble in water but readily soluble in ethanol and other organic solvents, reflecting the increased lipophilicity gained when the parent alkaloid's quaternary ammonium group is reduced to a tertiary amine. For finished-product formulation, this profile favors oil-based softgel suspensions, lipid or self-emulsifying (SEDDS/SMEDSS) delivery systems, or micronization/particle-size reduction combined with wetting agents to improve dispersibility in aqueous or powder-blend applications. Buyers formulating aqueous or effervescent products should pilot-test dispersion and consider co-processing with solubilizers or carrier excipients.
Standard grade is ≥98.0% purity by HPLC, supplied as a yellow crystalline powder with full heavy metal and microbial testing. A batch-specific Certificate of Analysis is provided with every shipment; higher-purity or custom specifications can be discussed on request.
It is manufactured semi-synthetically: berberine is first extracted and purified from selected berberine-rich botanical raw material, then converted to dihydroberberine through a controlled catalytic reduction step, followed by crystallization, drying, and quality testing.
It is slightly soluble in water and readily soluble in ethanol. For most finished products, oil-based softgel suspensions, lipid delivery systems, or micronized powder blends with a wetting agent give the most consistent results; our technical team can advise based on your target dosage form.
Yes, small samples are available for formulation testing and internal evaluation. Please contact our sales team with your intended application and shipping details to arrange a sample.
Yes. In addition to our in-house Certificate of Analysis, we support sending samples to a third-party laboratory of the buyer's choice for independent verification of purity, heavy metals, and microbial limits.
Yes, we offer OEM/ODM and private-label support, including custom blends, capsule/tablet formulation assistance, and packaging design tailored to your brand requirements.
Standard packaging includes 1 kg and 25 kg fiber drums with double food-grade polyethylene liners to protect against moisture and light; custom packaging sizes and labeling can be arranged for larger or OEM orders.
MOQ varies by order form (sample, trial batch, or bulk) and can be confirmed by our sales team based on your target volume and delivery timeline; please reach out with your requirements for a formal quotation.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
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Alex Huang · Mon–Fri 9am–6pm CST
