IQC
CAS 482-35-9
Purity≥98.0%
Quercetin glycoside for botanical antioxidant formulation work
Isoquercitrin (Isoquercetin) Powder (CAS 482-35-9), specification ≥98.0%. Isoquercitrin, also called isoquercetin, is quercetin monoglucoside; it differs from quercetin and enzyme-modified mixtures. Batch COA and evaluation samples are available. MOQ: 1 kg. nutrition & functional ingredients
Quote / sample & delivery
Key Specifications
| Product Positioning | Quercetin glycoside for botanical antioxidant formulation work |
| Application Scenarios | flavonoid formulation screening · botanical antioxidant research · water-dispersible powders |
| CAS Number | 482-35-9 |
| Purity | ≥98.0% |
| Molecular Formula | C₂₁H₂₀O₁₂ |
| Molecular Weight | 464.38 g/mol |
| Appearance | Light yellow to yellow powder |
| Solubility | Soluble in water (better than quercetin) |
| Storage | Room temperature, dry |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Isoquercitrin (isoquercetin, CAS 482-35-9) is a natural flavonol glycoside consisting of the aglycone quercetin linked to a single glucose unit at the 3-O position (molecular formula C21H20O12, MW 464.38 g/mol). It occurs widely across the plant kingdom—in apples, mulberry leaves, tea, buckwheat, and Sophora japonica flower buds—but almost always at trace concentrations, making direct extraction commercially inefficient. Bulk-scale material is therefore typically produced through a biosynthesis/enzymatic conversion route: rutin (quercetin-3-O-rutinoside), which is abundant and inexpensively extracted from botanical sources such as Sophora japonica, is treated with a selective α-L-rhamnosidase enzyme that cleaves off the terminal rhamnose unit, leaving isoquercitrin as the product, which is then purified by crystallization/chromatography to high purity.
High, Verified Purity
Standard grade is HPLC-assayed at ≥98.0% purity, with each production lot backed by a certificate of analysis so buyers can confirm potency before use.
Controlled Enzymatic Bioconversion
Produced via selective enzymatic conversion of rutin using α-L-rhamnosidase under tightly controlled reaction and purification parameters, ensuring batch-to-batch consistency at commercial scale.
Consistent Powder Form
Supplied as a light yellow to yellow, free-flowing crystalline powder with consistent particle characteristics suitable for direct formulation or further processing.
Full Contaminant Screening
Every batch is screened for heavy metals (lead, arsenic, mercury, cadmium), residual solvents, and microbial limits to meet food- and pharma-grade raw material expectations.
Flexible Bulk & OEM Supply
Available in bulk quantities with customizable packaging, particle size, and documentation, plus OEM/private-label support for finished-product brand owners.
Test items, specifications and results for the listed batch are shown here. View or request a COA in the quality documents section.
Batch No.
PGIQ-260105
Test date
2026-01-06
Specification
In-house
Pack size
25kg/carton
Storage
Room temperature, dry
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | Light yellow to yellow powder | Conforms |
| Odor | Characteristic, no foreign odor | Conforms |
| Assay (HPLC) | ≥98.0% | 98.6% |
| Related substances (single max impurity) | ≤0.5% | 0.3% |
| Particle size | 100% pass 80 mesh | Conforms |
| Loss on drying | ≤5.0% | 2.8% |
| Residue on ignition | ≤0.5% | 0.2% |
| Lead (Pb) | ≤2 mg/kg | <1 mg/kg |
| Arsenic (As) | ≤1 mg/kg | <0.5 mg/kg |
| Mercury (Hg) | ≤0.1 mg/kg | <0.05 mg/kg |
| Cadmium (Cd) | ≤0.3 mg/kg | <0.1 mg/kg |
| Total plate count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & mold | ≤100 CFU/g | <10 CFU/g |
| E. coli | Negative /25g | Negative |
| Salmonella | Negative /25g | Negative |
View an available COA in the quality documents section. Check the document for its product form and batch; request a signed COA for your purchasing or shipment batch separately.
Hard capsules
Distinguish isoquercetin from quercetin and other glycosides; the EGCG and fish-oil formats in studies do not automatically establish suitability here.
98.6%
Assay (HPLC)
0.3%
Related substances (single max impurity)
PGIQ-260105 · Results apply to this lot; interpret purity, assay and water on their respective bases.
Composition candidates, processing sequences and tests support pilot design. Confirm candidate excipients and processes using this material in the actual finished formulation.
Application examples follow the materials, formats and findings actually studied. Combination studies, single-ingredient studies, commercial precedents and development candidates are distinguished.
Polyphenol/omega-3 development spans aqueous/lipid systems and needs dispersion, oxidation and individual-active controls.
Show research and formulation insights +Hide details −Combination / selection rationale: Polyphenol/omega-3 development spans aqueous/lipid systems and needs dispersion, oxidation and individual-active controls.
Published evidence / source details: A 2016 10-week Q-Mix trial in 48 women also included quercetin, vitamin C, niacinamide and folic acid. Circulating markers/transcriptomic pathways changed, while CRP, F₂-isoprostanes and cytokines did not significantly change.
Development insights: Compare separate oil/polyphenol formats with encapsulated-fish-oil powder premixes. Assay isoquercetin, EGCG, EPA/DHA and oxidation individually, documenting filling uniformity and storage colour.
Evidence scope: The study was not a three-component blend and cannot isolate isoquercetin or arbitrary three-way synergy.
2016 · A Mixed Flavonoid-Fish Oil Supplement Induces Immune-Enhancing and Anti-Inflammatory Transcriptomic Changes in Adult Obese and Overweight Women-A Randomized Controlled Trial. · DOI 10.3390/nu8050277 ↗Isoquercetin/ascorbic acid is a solid-form candidate requiring distinct isoquercetin, quercetin and vitamin-C assays.
Show research and formulation insights +Hide details −Combination / selection rationale: Isoquercetin/ascorbic acid is a solid-form candidate requiring distinct isoquercetin, quercetin and vitamin-C assays.
Published evidence / source details: Q-Mix coadministered isoquercetin and vitamin C among several ingredients, without isolating the two-component effect.
Development insights: Compare singles, blend and carrier blank across premixing, moisture and acidity. Assay both actives initially and during storage; liquids need concentration-specific dissolution/dispersion trials without equating suspension or other glycosides with soluble supply grades.
Evidence scope: Coadministration precedent, not proof of exact two-component human synergy.
2016 · A Mixed Flavonoid-Fish Oil Supplement Induces Immune-Enhancing and Anti-Inflammatory Transcriptomic Changes in Adult Obese and Overweight Women-A Randomized Controlled Trial. · DOI 10.3390/nu8050277 ↗Literature-Supported Research Directions
In healthy adults and participants with persistent antiphospholipid antibodies, oral isoquercetin inhibited plasma protein disulfide isomerase activity and reduced platelet-dependent thrombin generation. This mechanistic human study does not support unsupervised anticoagulant use.
Citation: Stopa et al., Journal of Clinical Investigation 127 (2017), 594–608. PMID: 28097231.View source
A phase II multicenter study evaluated 500 or 1,000 mg/day isoquercetin for 56 days in patients with advanced cancer and reported changes in D-dimer and other coagulation endpoints. The population and doses were medical-research specific and are not transferable to general wellness products.
Citation: Zwicker et al., JCI Insight 4 (2019), e125851. PMID: 30652973.View source
In a randomized double-blind placebo-controlled trial of 46 adults with sickle cell disease, isoquercetin did not improve the primary soluble P-selectin endpoint. Several coagulation and platelet biomarkers moved in a favorable direction, providing exploratory—not definitive—evidence.
Citation: Lizarralde-Iragorri et al. Isoquercetin for thromboinflammation in sickle cell disease: a randomized double-blind placebo-controlled trial. Blood advances (2024). PMID: 38157227.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
1 kg
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Raw Material Sourcing (Rutin Extraction)
Rutin, the natural precursor, is extracted and purified from botanical sources such as Sophora japonica (pagoda tree) flower buds or buckwheat, where it occurs at relatively high concentration.
Rutin Standardization
Extracted rutin is standardized for purity and concentration and dissolved into an aqueous or buffered reaction medium to prepare it for enzymatic conversion.
Enzyme Preparation
A selective α-L-rhamnosidase enzyme (produced via microbial fermentation) is prepared and quality-checked for activity to ensure efficient, specific cleavage of the rhamnose unit.
Enzymatic Bioconversion
Under controlled temperature and pH, the enzyme selectively hydrolyzes the terminal rhamnose from rutin's rutinoside moiety, converting it into isoquercitrin while leaving the glucose linkage intact.
Reaction Monitoring & Termination
Conversion progress is monitored (typically by HPLC) until conversion yield plateaus, at which point the reaction is terminated to prevent further hydrolysis to the quercetin aglycone.
Separation & Crystallization
The reaction mixture is filtered, and isoquercitrin is separated from residual rutin, free rhamnose, and quercetin byproducts through crystallization and/or chromatographic purification.
Drying & Milling
The purified crystals are dried under controlled conditions to the target moisture level and milled to achieve consistent particle size for the finished powder.
QC Testing & Packaging
Finished material undergoes full QC testing (purity, heavy metals, microbial limits) before being packaged under conditions that protect it from light and moisture.
Purity is routinely confirmed by reversed-phase HPLC with UV detection, referencing a certified isoquercitrin standard and quantifying against a calibration curve; the method also resolves closely related impurities such as residual rutin and free quercetin. Buyers sourcing isoquercitrin for pharmaceutical, dietary supplement, or cosmetic applications should request the current certificate of analysis, confirm the specific assay method and reference standard used, and independently verify results via a qualified third-party laboratory where regulatory submission or high-value formulation is involved.
Commercial isoquercetin supplements are represented primarily by hard capsules. Confirm identity versus other quercetin glycosides, dissolution, assay, excipient compatibility and target-market dose and claim limits. Clinical studies at pharmacological research doses should not be copied directly into consumer supplement directions.
Each shipment is accompanied by a certificate of analysis (COA) covering HPLC assay, appearance, heavy metals, and microbial limits. We can also provide a pre-shipment sample and, on request, share the specific HPLC method and reference standard used for verification.
Our isoquercitrin is produced through a controlled enzymatic bioconversion process: plant-derived rutin (extracted from Sophora japonica flower buds) is selectively converted using an α-L-rhamnosidase enzyme, which is far more efficient than direct plant extraction since isoquercitrin occurs only in trace amounts in nature.
Yes, isoquercitrin is more water-soluble than quercetin due to its attached glucose unit, making it suitable for beverages, aqueous supplements, and topical formulations. For higher-solubility needs, cyclodextrin complexation or micronization can be explored — our technical team can advise based on your target matrix.
Yes, small evaluation samples are typically available for qualified buyers to test purity, solubility, and compatibility with their formulation before committing to a bulk purchase order.
Absolutely. We welcome buyers to send retained samples to an independent, accredited laboratory of their choice for verification, and can coordinate sample retention and chain-of-custody documentation to support this process.
Yes, we support OEM and private-label supply, including customized packaging, labeling, and documentation to match your brand requirements for finished dietary supplement or ingredient products.
Standard packaging includes 1 kg, 5 kg, and 25 kg fiber drums or aluminum foil bags with double-layer moisture protection; customized packaging sizes and materials can be arranged for larger or OEM orders.
The raw-material MOQ for isoquercitrin powder is 1 kg, with pack options of 1 kg, 5 kg, 25 kg. Typical lead time is 3–5 business days, with dispatch confirmed for the order.
No. Isoquercetin/isoquercitrin is quercetin 3-O-glucoside, distinct from aglycone quercetin and enzymatically modified oligoglucoside mixtures. Confirm composition and assay before changing a formulation. A multicomponent fish-oil study or an EMIQ trial does not establish equivalent effects for another glycoside.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Check the COA for the applicable batch
Technical Resources
Related Products
Citicoline (CDP-Choline) Powder
Gamma-Aminobutyric Acid (GABA) Powder
Reduced L-Glutathione Powder (GSH)
Interested in IQC?
Our R&D team will respond to your inquiry or sample request within 24 hours.
Scan to add WeChat
Alex Huang · Mon–Fri 9am–6pm CST
