NANA
CAS 131-48-6
Purity≥98.0%
Sialic-acid material for glyconutrient and personal-care research
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore nutrition & functional ingredients.
Confirm N-acetylneuraminic acid identity and purity basis.
Key Specifications
| Product Positioning | Sialic-acid material for glyconutrient and personal-care research |
| Application Scenarios | sialic-acid nutrition formulas · glycobiology research · water-soluble personal-care prototypes |
| CAS Number | 131-48-6 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₁H₁₉NO₉ |
| Molecular Weight | 309.27 g/mol |
| Appearance | White crystalline powder |
| Solubility | Freely soluble in water |
| Storage | Room temperature, dry |
| Shelf Life | 24 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
N-Acetylneuraminic acid (Neu5Ac, NANA), commonly called sialic acid, is a nine-carbon acidic amino sugar found at terminal positions of glycoproteins and glycolipids. Its formula is C11H19NO9, molecular weight 309.27 g/mol and CAS number 131-48-6. Commercial material can be manufactured through microbial biosynthesis followed by enzymatic conversion, purification and crystallization.
High Purity, ≥98.0%
Each batch is assayed by HPLC to confirm purity of 98.0% or above, meeting the requirements of infant nutrition, cognitive-health, and cosmetic formulations.
Biofermentation-Derived, Traceable Process
Produced via a controlled microbial fermentation and enzymatic bioconversion platform rather than animal extraction, giving a consistent, green, and sustainable supply chain.
Free-Flowing White Crystalline Powder
Supplied as a fine white crystalline powder that is freely soluble in water, simplifying handling, weighing, and downstream blending.
Endotoxin & Contaminant Controlled
Every lot ships with an endotoxin control test report alongside heavy-metal and microbial limit data, supporting use in sensitive infant and clinical-adjacent applications.
Flexible Bulk & OEM Supply
Available in flexible bulk packaging with OEM/private-label options, sample-size orders, and documentation support for regulatory submissions.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGSA-260308
Test date
2026-03-09
Specification
In-house
Pack size
25kg/carton
Storage
Room temperature, dry
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White crystalline powder | Conforms, white crystalline powder |
| Odor & Taste | Characteristic, no foreign odor | Conforms |
| Assay (HPLC) | ≥98.0% | 98.6% |
| Specific Rotation [α]D20 | +18° to +26° (c=2, H2O) | +21.5° |
| Loss on Drying | ≤1.0% | 0.4% |
| pH (1% aqueous solution) | 1.5-3.5 | 2.3 |
| Heavy Metals (as Pb) | ≤10 ppm | <5 ppm |
| Lead (Pb) | ≤2 mg/kg | <1 mg/kg |
| Arsenic (As) | ≤2 mg/kg | <1 mg/kg |
| Mercury (Hg) | ≤0.1 mg/kg | <0.05 mg/kg |
| Cadmium (Cd) | ≤1 mg/kg | <0.5 mg/kg |
| Total Plate Count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mold | ≤100 CFU/g | <10 CFU/g |
| E. coli / Salmonella | Negative/25g | Not detected |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Infant and follow-on formula
Young-child nutrition powders
Fortified foods
Hard capsules
Tablets and chewables
Oral liquids and syrups
Serums and essences
Creams and lotions
Facial masks
The combination can support a human-milk-inspired specialized-nutrition concept, with NANA contributing free sialic acid and HMOs contributing defined oligosaccharide structures.
Evidence: This is a formulation concept, not proof of clinical synergy. Infant and young-child products require market-specific authorization, cumulative-intake review and age-appropriate labeling.Source
This pairing can be evaluated in early-life and cognitive-nutrition formulas because the ingredients occupy different structural and metabolic roles.
Evidence: Mechanistic and category-level rationale only; no direct human trial proving superiority of this exact combination was identified.
Literature-Supported Research Directions
In a small study involving patients with NANS deficiency and healthy controls, oral free Neu5Ac increased plasma concentrations within hours but was also rapidly excreted in urine. The study did not support treatment efficacy for NANS deficiency and should be interpreted as preliminary pharmacokinetic evidence.
Citation: Tran et al., Molecular Genetics and Metabolism Reports 28 (2021), 100777. PMID: 34258226.View source
An open-label observational pilot followed five patients with NANS-CDG receiving oral sialic acid. The rare-disease setting, very small sample and absence of a placebo group mean that findings cannot be generalized to consumer nutrition or cognitive-health claims.
Citation: den Hollander et al., Journal of Inherited Metabolic Disease 46 (2023). PMID: 37340906.View source
EFSA assessed synthetic N-acetyl-D-neuraminic acid for infant formula, foods and supplements. It concluded safety under specified uses, while noting that supplement use at the proposed levels was not established for children below 10 years. Conditions of use and labeling remain market specific.
Citation: EFSA NDA Panel, EFSA Journal 15 (2017), 4918. DOI: 10.2903/j.efsa.2017.4918.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
100 g
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
Strain Activation & Seed Culture
A proprietary production strain (typically an engineered E. coli or Bacillus subtilis line) is revived from the working cell bank and expanded through seed-stage cultivation under sterile conditions.
Fed-Batch Fermentation
Seed culture is transferred to production bioreactors and fed simple carbon/nitrogen sources (such as glucose and GlcNAc-related precursors) under controlled temperature, pH, and dissolved oxygen to drive cell growth and precursor accumulation.
Enzymatic Bioconversion
An epimerase converts the accumulated amino-sugar precursor to N-acetylmannosamine, which is then condensed with pyruvate by a sialic acid aldolase (whole-cell or isolated enzyme system) to form N-acetylneuraminic acid.
Cell Removal & Clarification
Fermentation/bioconversion broth is centrifuged and microfiltered to remove cell mass and insoluble debris, yielding a clarified aqueous solution of crude NANA.
Decolorization & Ion-Exchange Purification
The clarified solution is treated with activated carbon for decolorization and passed through ion-exchange resin columns to remove salts, proteins, and colored impurities.
Concentration & Crystallization
The purified solution is concentrated under vacuum and cooled/seeded to induce controlled crystallization of N-acetylneuraminic acid.
Drying & Milling
Wet crystals are separated by centrifugation, dried under vacuum or low-temperature conditions, and milled/sieved to the target particle size.
QC Testing & Packaging
Finished powder is sampled for HPLC purity, heavy metals, microbial limits, and endotoxin testing before being packed under controlled humidity for shipment.
Purity is determined by high-performance liquid chromatography (HPLC) with UV or refractive-index detection against a qualified reference standard, which reliably separates NANA from residual precursor sugars, salts, and process-related impurities. Buyers evaluating a lot should confirm the specific HPLC method (column, mobile phase, detection wavelength) and reference standard traceability used to generate the certificate of analysis, and may request an independent third-party retest for critical applications such as infant formula or clinical-adjacent products.
NANA is water-soluble and appears in authorized or marketed nutrition formats including formula powders, fortified foods, capsules, tablets, chewables and liquid/syrup products. It is also marketed for cosmetic lotions, creams, essences and masks. Validate heat/pH stability, microbiological controls and target-market permissions in the finished matrix.
Each batch is assayed by HPLC against a qualified reference standard and documented in a certificate of analysis (COA); we can supply the COA together with the specific test method for buyer review before or after shipment.
It is produced through a controlled microbial fermentation and enzymatic bioconversion platform rather than animal or plant extraction, giving a consistent, traceable, and sustainable production route.
Yes, NANA is freely soluble in water and forms clear, stable solutions, making it well suited to infant formula, beverages, oral liquids, and cosmetic serums; we recommend confirming stability under your specific heat and pH conditions.
Yes, small sample quantities are available on request for formulation trials and internal QC evaluation prior to committing to a bulk order.
Yes, in addition to our internal COA and endotoxin control report, buyers are welcome to send retained samples to an independent laboratory of their choice for verification.
Yes, we offer OEM/private-label packaging and documentation support, including custom labeling and technical files to assist with your regulatory submissions.
Standard packaging is typically in food/pharma-grade drums or fiber drums with inner poly liners (commonly 1 kg, 5 kg, or 25 kg), with custom packaging sizes available on request.
MOQ varies by intended application and packaging format; please contact our sales team with your target volume, application, and destination country so we can prepare a tailored quotation and lead-time estimate.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
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Alex Huang · Mon–Fri 9am–6pm CST
