SAMe
S-Adenosylmethionine Tosylate Sulfate
Key Specifications
| CAS Number | 81190-38-1 |
| Purity | ≥97.0% |
| Molecular Formula | C₁₅H₂₂N₆O₅S·C₇H₇SO₃·H₂SO₄ |
| Molecular Weight | 766.86 g/mol |
| Appearance | White to off-white hygroscopic powder |
| Solubility | Soluble in water |
| Storage | ≤-20°C, protect from light and moisture |
| Shelf Life | 18 months |
CAS 81190-38-1
What Is SAMe?
S-Adenosylmethionine (SAMe) tosylate sulfate is a stabilized double-salt form of S-adenosyl-L-methionine (CAS 81190-38-1), a naturally occurring sulfonium compound found in virtually every living cell, where it serves as the principal methyl donor for DNA, protein, and phospholipid methylation. The free SAMe cation (C15H22N6O5S, active moiety MW about 398) is intrinsically unstable and highly hygroscopic, so commercial bulk material is co-formed with p-toluenesulfonic acid and sulfuric acid to give this tosylate sulfate complex (C15H22N6O5S·C7H7SO3·H2SO4, MW 766.86), which resists racemization and oxidative degradation far better than the free base. At industrial scale, SAMe is not chemically synthesized from petrochemical feedstock but produced biologically: high-density yeast fermentation, commonly using engineered Saccharomyces cerevisiae strains, converts fed L-methionine and ATP into SAMe via methionine adenosyltransferase, after which the intracellular product is extracted, purified, and precipitated as the stable salt described here.
Other Names
Key Features
High-Purity, HPLC-Verified
Each batch is assayed to ≥97.0% purity by validated HPLC methods, with full certificates of analysis available on request to confirm consistency batch to batch.
Controlled Fermentation-Based Biosynthesis
Produced via high-density yeast fermentation under tightly controlled methionine feed, pH, and temperature profiles, ensuring reproducible enzymatic conversion to SAMe batch after batch.
Uniform White to Off-White Powder
Supplied as a free-flowing, uniform white to off-white hygroscopic powder, packed under moisture-controlled conditions to preserve appearance and potency during storage and transport.
Full Heavy Metal & Microbial Screening
Every batch is screened for lead, mercury, cadmium and arsenic, plus microbial limits (total plate count, yeast/mould, E. coli, Salmonella), in line with EP requirements.
Flexible Bulk Supply & OEM Support
Available in bulk quantities from EP- and ISO-certified manufacturing, plus custom packaging sizes, labeling and OEM/private-label formulation support for finished-goods brands.
| Molecular Formula | C₁₅H₂₂N₆O₅S·C₇H₇SO₃·H₂SO₄ |
| Molecular Weight | 766.86 g/mol |
| Appearance | White to off-white hygroscopic powder |
| Solubility | Soluble in water |
| Storage Condition | ≤-20°C, protect from light and moisture |
| Shelf Life | 18 months |
| Grade 1 | Pharmaceutical Grade · ≥97.0% · EP |
End-Product Applications
Mechanism & Benefits
Universal methyl donor. Regulates methylation reactions, improves mood, liver protection and joint comfort.
Packaging Options
100 g 500 g 1 kg
Lead Time
7–10 business days
Minimum Order
100 g
Custom Packaging
Custom packaging (foil bags, HDPE drums), GMP labeling, and export documentation are available. Contact us for specifics.Certifications
EP
European Pharmacopoeia
ISO
ISO
Manufacturing Process
Strain Preparation & Seed Culture
A high-yield SAMe-producing yeast strain (typically an engineered Saccharomyces cerevisiae) is revived from the working cell bank and expanded through seed fermenters to build sufficient healthy biomass.
Fed-Batch Fermentation
The seed culture is transferred to production fermenters where L-methionine and glucose are fed under controlled aeration, pH and temperature, driving intracellular conversion of methionine and ATP into SAMe via methionine adenosyltransferase.
Biomass Harvest & Cell Disruption
Fermentation broth is centrifuged to concentrate the yeast biomass, which is then mechanically or enzymatically lysed to release the intracellular SAMe into solution.
Clarification & Primary Purification
The crude lysate is clarified to remove cell debris, then passed through ion-exchange or chromatographic resins to separate SAMe from residual protein, nucleic acids, and unconverted methionine.
Salt Formation & Stabilization
The purified SAMe cation is combined with p-toluenesulfonic acid and sulfuric acid under controlled conditions to form the tosylate sulfate double salt, which is markedly more resistant to racemization and oxidative degradation than free SAMe.
Crystallization & Isolation
The double salt is crystallized from the purified solution, then filtered and washed to remove residual mother liquor and process impurities.
Low-Temperature Drying & Milling
Wet crystals are dried under vacuum or low-temperature conditions to protect the heat-sensitive sulfonium center, then milled to the target particle size for a free-flowing bulk powder.
Quality Control & Packaging
Finished material undergoes HPLC assay, heavy metal and microbial testing, then is packed in moisture-barrier containers with desiccant under appropriate temperature control.
Quality Specifications
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white hygroscopic powder | White to off-white hygroscopic powder, complies |
| Odor | Odorless or faint characteristic odor | Odorless |
| Identification (HPLC retention time) | Matches reference standard | Conforms |
| Assay (Purity, HPLC) | ≥97.0% | 97.8% |
| Diastereomer ratio (S,S-isomer) | ≥75% | 81% |
| Loss on Drying | ≤5.0% | 3.1% |
| Heavy Metals (Pb) | ≤10 ppm | <5 ppm |
| Arsenic (As) | ≤2 ppm | <1 ppm |
| Mercury (Hg) | ≤1 ppm | <0.5 ppm |
| Cadmium (Cd) | ≤1 ppm | <0.5 ppm |
| Total Plate Count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mould | ≤100 CFU/g | <10 CFU/g |
| E. coli | Negative/10 g | Negative |
| Salmonella | Negative/10 g | Negative |
Purity & Assay Method
Purity is determined by validated reversed-phase or ion-pair HPLC with UV detection at 254-260 nm, comparing retention time and peak area against a certified SAMe reference standard. Because commercial SAMe exists as a mixture of (S,S) and (R,S) diastereomers, buyers should also confirm the active (S,S)-isomer ratio and the tosylate/sulfate counter-ion stoichiometry stated on the certificate of analysis, and request a batch-specific COA before placing a large-volume order.
Solubility & Formulation
This tosylate sulfate salt is freely soluble in water, which supports its use in oral solid dosage forms (enteric-coated or film-coated tablets/capsules) as well as sachets and effervescent formats. Because the free SAMe cation is both hygroscopic and sensitive to heat, moisture and alkaline pH, formulators are generally advised to keep processing temperatures low, use moisture-barrier packaging with desiccant, and consider mildly acidic buffering or enteric coating to protect the sulfonium center through gastric transit and shelf storage.
Available Product Forms
Bulk SAMe Powder
High-purity raw powder for supplement factories, research organizations, ingredient distributors, and contract manufacturers.
SAMe Capsules
Custom capsule strength, shell material, bottle count, excipients, and label design for private-label brands.
SAMe Tablets
Tablet formulation, granulation, compression, coating, bottle packaging, and custom labeling support.
SAMe Powder Blends
SAMe can be blended with complementary actives (antioxidants, other longevity ingredients, vitamins, minerals) per customer formula.
Can you confirm the exact purity and specifications before I place an order?+
Yes. Every batch ships with a certificate of analysis showing HPLC purity (≥97.0%), diastereomer ratio, heavy metal and microbial results, and appearance data; we're also glad to share a pre-shipment sample COA for your internal review.
How is this SAMe salt actually produced — is it fermented or chemically synthesized?+
The active SAMe is produced biologically through controlled fed-batch fermentation of a high-yield yeast strain fed with L-methionine, followed by extraction, purification and stabilization into the tosylate sulfate double salt — it is not a petrochemical synthesis.
Is the material soluble in water, and can it be used in liquid or effervescent formulations?+
Yes, it is freely soluble in water; however, since the sulfonium center is sensitive to heat and pH, we recommend low-temperature processing and mildly acidic conditions for any liquid or effervescent formulation work — our technical team can advise on formulation stability.
Can we request a free sample before committing to a bulk order?+
Yes, small samples are available on request for quality evaluation and formulation trials; please contact our sales team with your intended application and shipping details.
Can the product be verified by third-party or independent lab testing?+
Yes. In addition to our internal COA, we support and encourage third-party or independent laboratory verification of purity, isomer ratio, heavy metals and microbial limits for any batch you purchase.
Do you offer OEM or private-label supply for finished-goods brands?+
Yes, we support OEM and private-label programs, including custom packaging sizes, labeling, and formulation guidance for supplement or pharmaceutical-adjacent brands sourcing bulk SAMe.
What packaging options are available, and how should the material be stored?+
Standard packaging uses moisture-barrier aluminum foil bags or fiber drums with desiccant, in various bulk sizes; because the powder is hygroscopic, it should be stored sealed, cool, dry and protected from light until use.
What is the MOQ, and how can I get a formal quotation?+
MOQ is flexible and depends on packaging format and destination; please reach out with your target quantity, application and delivery location, and our team will prepare a formal quotation along with lead time.
Why Choose PathGene
- Direct China manufacturer supply — factory pricing, no middleman
- Batch-specific COA & full traceability on every shipment
- In-house R&D + synthetic biology / enzymatic production platform
- Free sample for qualified B2B buyers before commercial order
- Flexible MOQ — from lab-scale trial to ton-scale commercial supply
- One-stop OEM/private-label support for finished dosage forms
- Worldwide shipping by courier, air freight, and sea freight
OEM & Private-Label Services
- ·Custom capsule manufacturing
- ·Custom tablet manufacturing
- ·Powder blending & custom formulation
- ·Private-label bottles, pouches & labels
- ·Small trial orders
- ·Bulk commercial production
- ·Export documentation
- ·Third-party laboratory testing
Documents Available
- ·Certificate of Analysis (COA)
- ·Product specification sheet
- ·Material Safety Data Sheet (MSDS)
- ·Manufacturing flow chart
- ·HPLC test report
- ·Heavy-metal test report
- ·Microbiological test report
- ·Non-GMO / allergen statement
- ·Country-of-origin documentation
- ·Packing list & commercial invoice
Certificate availability should be confirmed with our sales team before ordering.
Sample Certificate of Analysis
PathGene Biotech Co., Ltd.
南京派琪生物科技有限公司
CERTIFICATE OF ANALYSIS
Layout example — not an issued batch record
Product Name
SAMe
CAS No.
81190-38-1
Batch No.
PG-SAMPLE-000000
Packaging
Issued upon order confirmation
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white hygroscopic powder | White to off-white hygroscopic powder, complies |
| Odor | Odorless or faint characteristic odor | Odorless |
| Identification (HPLC retention time) | Matches reference standard | Conforms |
| Assay (Purity, HPLC) | ≥97.0% | 97.8% |
| Diastereomer ratio (S,S-isomer) | ≥75% | 81% |
| Loss on Drying | ≤5.0% | 3.1% |
| Heavy Metals (Pb) | ≤10 ppm | <5 ppm |
| Arsenic (As) | ≤2 ppm | <1 ppm |
| Mercury (Hg) | ≤1 ppm | <0.5 ppm |
| Cadmium (Cd) | ≤1 ppm | <0.5 ppm |
| Total Plate Count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mould | ≤100 CFU/g | <10 CFU/g |
| E. coli | Negative/10 g | Negative |
| Salmonella | Negative/10 g | Negative |
Conclusion: Conforms to internal quality specifications
The COA issued with your order will carry the actual batch number, manufacture/test dates, and QC signature.
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