SAMe
CAS 81190-38-1
Purity≥97.0%
Methyl-donor compound for biochemical and nutrition research
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore nutrition & functional ingredients.
Confirm tosylate-sulfate salt and SAMe stability.
Key Specifications
| Product Positioning | Methyl-donor compound for biochemical and nutrition research |
| Application Scenarios | methyl-donor research · nutrition tablet development · sulfur-metabolism assays |
| CAS Number | 81190-38-1 |
| Purity | ≥97.0% |
| Molecular Formula | C₁₅H₂₂N₆O₅S·C₇H₇SO₃·H₂SO₄ |
| Molecular Weight | 766.86 g/mol |
| Appearance | White to off-white hygroscopic powder |
| Solubility | Soluble in water |
| Storage | ≤-20°C, protect from light and moisture |
| Shelf Life | 18 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
S-Adenosylmethionine (SAMe) tosylate sulfate is a stabilized double-salt form of S-adenosyl-L-methionine (CAS 81190-38-1), a naturally occurring sulfonium compound found in virtually every living cell, where it serves as the principal methyl donor for DNA, protein, and phospholipid methylation. The free SAMe cation (C15H22N6O5S, active moiety MW about 398) is intrinsically unstable and highly hygroscopic, so commercial bulk material is co-formed with p-toluenesulfonic acid and sulfuric acid to give this tosylate sulfate complex (C15H22N6O5S·C7H7SO3·H2SO4, MW 766.86), which resists racemization and oxidative degradation far better than the free base. At industrial scale, SAMe is not chemically synthesized from petrochemical feedstock but produced biologically: high-density yeast fermentation, commonly using engineered Saccharomyces cerevisiae strains, converts fed L-methionine and ATP into SAMe via methionine adenosyltransferase, after which the intracellular product is extracted, purified, and precipitated as the stable salt described here.
High-Purity, HPLC-Verified
Each batch is assayed to ≥97.0% purity by validated HPLC methods, with full certificates of analysis available on request to confirm consistency batch to batch.
Controlled Fermentation-Based Biosynthesis
Produced via high-density yeast fermentation under tightly controlled methionine feed, pH, and temperature profiles, ensuring reproducible enzymatic conversion to SAMe batch after batch.
Uniform White to Off-White Powder
Supplied as a free-flowing, uniform white to off-white hygroscopic powder, packed under moisture-controlled conditions to preserve appearance and potency during storage and transport.
Full Heavy Metal & Microbial Screening
Every batch is screened for lead, mercury, cadmium and arsenic, plus microbial limits (total plate count, yeast/mould, E. coli, Salmonella), in line with EP requirements.
Flexible Bulk Supply & OEM Support
Available in bulk quantities from EP-referenced manufacturing, plus custom packaging sizes, labeling and OEM/private-label formulation support for finished-goods brands.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PG03-260516
Test date
2026-05-17
Specification
In-house
Pack size
25kg/carton
Storage
≤-20°C, protect from light and moisture
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white hygroscopic powder | White to off-white hygroscopic powder, complies |
| Odor | Odorless or faint characteristic odor | Odorless |
| Identification (HPLC retention time) | Matches reference standard | Conforms |
| Assay (Purity, HPLC) | ≥97.0% | 97.8% |
| Diastereomer ratio (S,S-isomer) | ≥75% | 81% |
| Loss on Drying | ≤5.0% | 3.1% |
| Heavy Metals (Pb) | ≤10 ppm | <5 ppm |
| Arsenic (As) | ≤2 ppm | <1 ppm |
| Mercury (Hg) | ≤1 ppm | <0.5 ppm |
| Cadmium (Cd) | ≤1 ppm | <0.5 ppm |
| Total Plate Count | ≤1000 CFU/g | <100 CFU/g |
| Yeast & Mould | ≤100 CFU/g | <10 CFU/g |
| E. coli | Negative/10 g | Negative |
| Salmonella | Negative/10 g | Negative |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
SAMe participates in methyl-group transfer. Methylfolate and vitamin B12 can be evaluated as related one-carbon nutrients, but the formula should be positioned as a research direction and reviewed for interactions and population restrictions.
Evidence: Mechanistic/adjunct evidence: methylfolate and B-vitamin combinations have been studied in metabolic and psychiatric settings; direct evidence for this exact SAMe salt combination is limited.Source
Literature-Supported Research Directions
SAMe is a major methyl donor involved in phospholipid, protein and neurotransmitter metabolism. It supports research into mood, hepatic metabolism and methylation pathways, while finished-product use must follow the target-market regulations.
Citation: Papakostas et al., American Journal of Clinical Nutrition (2012), review of SAMe as an adjunctive treatment for depression.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
100 g
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Insulated Box + Carton
For products requiring temperature-controlled transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
EP
European Pharmacopoeia
Strain Preparation & Seed Culture
A high-yield SAMe-producing yeast strain (typically an engineered Saccharomyces cerevisiae) is revived from the working cell bank and expanded through seed fermenters to build sufficient healthy biomass.
Fed-Batch Fermentation
The seed culture is transferred to production fermenters where L-methionine and glucose are fed under controlled aeration, pH and temperature, driving intracellular conversion of methionine and ATP into SAMe via methionine adenosyltransferase.
Biomass Harvest & Cell Disruption
Fermentation broth is centrifuged to concentrate the yeast biomass, which is then mechanically or enzymatically lysed to release the intracellular SAMe into solution.
Clarification & Primary Purification
The crude lysate is clarified to remove cell debris, then passed through ion-exchange or chromatographic resins to separate SAMe from residual protein, nucleic acids, and unconverted methionine.
Salt Formation & Stabilization
The purified SAMe cation is combined with p-toluenesulfonic acid and sulfuric acid under controlled conditions to form the tosylate sulfate double salt, which is markedly more resistant to racemization and oxidative degradation than free SAMe.
Crystallization & Isolation
The double salt is crystallized from the purified solution, then filtered and washed to remove residual mother liquor and process impurities.
Low-Temperature Drying & Milling
Wet crystals are dried under vacuum or low-temperature conditions to protect the heat-sensitive sulfonium center, then milled to the target particle size for a free-flowing bulk powder.
Quality Control & Packaging
Finished material undergoes HPLC assay, heavy metal and microbial testing, then is packed in moisture-barrier containers with desiccant under appropriate temperature control.
Purity is determined by validated reversed-phase or ion-pair HPLC with UV detection at 254-260 nm, comparing retention time and peak area against a certified SAMe reference standard. Because commercial SAMe exists as a mixture of (S,S) and (R,S) diastereomers, buyers should also confirm the active (S,S)-isomer ratio and the tosylate/sulfate counter-ion stoichiometry stated on the certificate of analysis, and request a batch-specific COA before placing a large-volume order.
This tosylate sulfate salt is freely soluble in water, which supports its use in oral solid dosage forms (enteric-coated or film-coated tablets/capsules) as well as sachets and effervescent formats. Because the free SAMe cation is both hygroscopic and sensitive to heat, moisture and alkaline pH, formulators are generally advised to keep processing temperatures low, use moisture-barrier packaging with desiccant, and consider mildly acidic buffering or enteric coating to protect the sulfonium center through gastric transit and shelf storage.
Yes. Every batch ships with a certificate of analysis showing HPLC purity (≥97.0%), diastereomer ratio, heavy metal and microbial results, and appearance data; we're also glad to share a pre-shipment sample COA for your internal review.
The active SAMe is produced biologically through controlled fed-batch fermentation of a high-yield yeast strain fed with L-methionine, followed by extraction, purification and stabilization into the tosylate sulfate double salt — it is not a petrochemical synthesis.
Yes, it is freely soluble in water; however, since the sulfonium center is sensitive to heat and pH, we recommend low-temperature processing and mildly acidic conditions for any liquid or effervescent formulation work — our technical team can advise on formulation stability.
Yes, small samples are available on request for quality evaluation and formulation trials; please contact our sales team with your intended application and shipping details.
Yes. In addition to our internal COA, we support and encourage third-party or independent laboratory verification of purity, isomer ratio, heavy metals and microbial limits for any batch you purchase.
Yes, we support OEM and private-label programs, including custom packaging sizes, labeling, and formulation guidance for supplement or pharmaceutical-adjacent brands sourcing bulk SAMe.
Standard packaging uses moisture-barrier aluminum foil bags or fiber drums with desiccant, in various bulk sizes; because the powder is hygroscopic, it should be stored sealed, cool, dry and protected from light until use.
MOQ is flexible and depends on packaging format and destination; please reach out with your target quantity, application and delivery location, and our team will prepare a formal quotation along with lead time.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
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Interested in SAMe?
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Alex Huang · Mon–Fri 9am–6pm CST
