DHEA
CAS 53-43-0
Purity≥98.0%
Steroid-hormone research material for analytical development
For B2B ingredient sourcing, request the specification, batch COA, sample, packaging and lead-time confirmation. Explore healthy-aging ingredients.
Confirm steroid identity, regulatory status and analytical purity.
Key Specifications
| Product Positioning | Steroid-hormone research material for analytical development |
| Application Scenarios | steroid analytical standards · hormone-research workflows · solid-dose screening |
| CAS Number | 53-43-0 |
| Purity | ≥98.0% |
| Molecular Formula | C₁₉H₂₈O₂ |
| Molecular Weight | 288.43 g/mol |
| Appearance | White crystalline powder |
| Solubility | Slightly soluble in water; soluble in ethanol |
| Storage | Room temperature, protect from light |
| Shelf Life | 36 months |
Procurement & delivery
Supply details confirmed by intended use, volume and target market
Dehydroepiandrosterone (DHEA, CAS 53-43-0) is an endogenous C19 steroid, chemically 3β-hydroxyandrost-5-en-17-one, with molecular formula C19H28O2 and molecular weight 288.43 g/mol. In the human body it is produced mainly by the adrenal cortex and serves as a key upstream precursor to androgens and estrogens. Structurally related steroidal precursors also occur naturally in certain plants, such as wild yam (Dioscorea species). Commercial bulk DHEA is typically manufactured semi-synthetically: plant-derived phytosterols (e.g., soybean sitosterol/stigmasterol) or diosgenin are converted through microbial side-chain cleavage and enzymatic biotransformation into steroidal intermediates, which are then finished through controlled chemical oxidation, purification and crystallization to yield high-purity DHEA.
High-Purity Assay
Each batch is manufactured and tested to meet ≥98.0% purity by HPLC, ensuring consistent potency for supplement and research formulations.
Controlled Biosynthetic Production
Produced via a semi-synthetic route from plant-derived sterols using microbial side-chain cleavage and enzymatic conversion, with tightly controlled intermediate steps for batch-to-batch consistency.
Uniform Crystalline Powder
Supplied as a white, free-flowing crystalline powder with controlled particle size, suitable for direct blending, encapsulation or further formulation.
Comprehensive Contaminant Testing
Every lot is screened for heavy metals (Pb, Hg, Cd, As), residual solvents and microbial limits, with full documentation available on request.
Flexible Bulk & OEM Supply
Available in flexible order quantities from sample size to bulk drums, with OEM/private-label packaging and customized specifications supported.
Test items, specifications and batch results are shown here; request the formal COA through the card below.
Batch No.
PGDHEA-260201
Test date
2026-02-02
Specification
In-house
Pack size
25 kg/drum
Storage
Room temperature, protect from light
Conclusion
Conforms
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White to off-white powder | White crystalline powder |
| Identification | HPLC main peak retention time consistent with reference | Complies |
| Solubility | ≥100 mg/ml | Complies |
| Purity | ≥99.0% | 99.72% |
| Assay (dry basis) | ≥97.0% | 99.2% |
| Melting range | 147–151℃ | 147.2℃ |
| Loss on drying | ≤8% | 0.15% |
| Specific rotation | +11.0 to +14.0° | +12.6° |
| Residue on ignition | ≤0.1% | Complies |
| Related substances | 4-AD ≤0.1%; other single impurity ≤0.3%; total ≤1.0% | 0.18%; total 0.28% |
| Residual solvents | Acetone ≤5000 ppm; ethyl acetate ≤5000 ppm; t-BuOH ≤1000 ppm | Complies |
This page shows a batch-data summary only. No direct COA file link is provided; request the signed document through the form below.
Hard capsules
Powders
Softgels
Tablets
Sublingual tablets
Oral dissolving films
DHEA and pregnenolone are marketed together as hormone-precursor capsules. Because both are steroid precursors, formulation and use should be reviewed for jurisdictional status, endocrine monitoring and contraindications.
Evidence: Commercial-formulation evidence: an NIH Dietary Supplement Label Database record documents a DHEA 100 mg + pregnenolone 100 mg capsule; this is not proof of clinical synergy.Source
Literature-Supported Research Directions
DHEA is an adrenal steroid precursor studied in endocrine and menopausal-health research. Clinical trials have examined oral and local routes, but outcomes vary by population, route and endpoint.
Citation: Elraiyah et al., Cochrane Database of Systematic Reviews (2015): DHEA for peri- or postmenopausal women.View source
A 52-week randomized study of oral DHEA in postmenopausal women did not identify significant changes in several assessed metabolic or endometrial outcomes, but androgenic effects and jurisdiction-specific regulation remain relevant. DHEA should be handled as a regulated hormone-related raw material, not an ordinary supplement ingredient.
Citation: Panjari et al., Menopause (2009): 52-week oral DHEA safety study.View source
Note: For ingredient R&D and scientific information; findings depend on model, dose, formulation and population and do not constitute a treatment claim or efficacy guarantee.
Lead Time
3–5business days
Standard products are generally in stock; confirm the exact lead time with us.
Minimum Order
1 kg
Samples, pilot trials, and commercial volumes are supported.
Foil Pouch
Sealed, moisture-protective inner packaging
Fiber Drum
Standard outer packaging for bulk transport
Bulk Shipping
Palletized and stretch-wrapped for protection
Ambient storage: foil pouch + fiber drum; temperature controlled: foil pouch + insulated box/carton. Confirm by product.
Custom packaging: Custom foil bags or HDPE drums, GMP label printing, and export documentation are available. Contact us for a quote.Images are packaging illustrations.
Certifications
USP
US Pharmacopoeia
Raw Material Sourcing
High-quality phytosterols (soybean-derived sitosterol/stigmasterol) or diosgenin from Dioscorea sources are selected and quality-checked as starting material.
Microbial Side-Chain Cleavage
Engineered microbial strains ferment the sterol substrate, selectively cleaving the aliphatic side chain to generate androstene-type steroidal intermediates.
Enzymatic Biotransformation
Biocatalytic steps refine the intermediate's stereochemistry and functional groups, establishing the 3β-hydroxy-Δ5 configuration characteristic of DHEA.
Chemical Oxidation & Rearrangement
Controlled protection/deprotection and oxidation steps introduce the 17-keto group, converting the intermediate into crude DHEA.
Extraction & Solvent Crystallization
Crude DHEA is extracted with food/pharma-grade organic solvent and crystallized to concentrate the target compound.
Purification & Recrystallization
Repeated recrystallization and activated-carbon decolorization remove residual solvents, related steroids and color bodies to raise purity above 98%.
Drying & Milling
The purified crystals are vacuum-dried and milled to achieve a uniform, free-flowing powder with controlled particle size.
Quality Control & Packaging
Finished material undergoes HPLC assay, heavy metal and microbial testing before being packed under protective conditions for shipment.
Purity is determined by reversed-phase HPLC with UV detection, referenced against a qualified DHEA working standard, and is reported as area-percent on an as-is basis. Because related steroidal impurities can co-elute with DHEA under poorly optimized conditions, buyers should request the full chromatogram and Certificate of Analysis, and confirm the specific column, mobile phase and detection wavelength used, especially for pharmaceutical or high-purity research applications.
DHEA is slightly soluble in water but readily soluble in ethanol and most polar organic solvents, which should be factored into formulation design. For oral supplement applications, common approaches include micronization to reduce particle size and improve dissolution, suspension in oil-based softgel carriers, or complexation with cyclodextrins/emulsifying systems to enhance dispersibility. Formulators should conduct compatibility and stability testing specific to their finished dosage form (tablet, capsule, softgel, or liquid) before scale-up.
Yes. We provide a Certificate of Analysis (CoA) with each shipment, and can share a pre-shipment CoA or sample results for your specific batch prior to order confirmation.
Our DHEA is produced through a semi-synthetic route starting from plant-derived phytosterols/diosgenin, using microbial side-chain cleavage and enzymatic biotransformation followed by controlled chemical finishing and purification.
DHEA is slightly soluble in water and soluble in ethanol. For oral formulations, micronization or oil-carrier suspension is commonly used to improve dispersibility; our technical team can advise based on your finished dosage form.
Yes, small evaluation samples are available on request, generally subject to shipping costs, so you can verify quality before placing a bulk order.
Yes, we support customer-arranged third-party laboratory testing and can assist with sample submission and documentation needed for independent verification.
Yes, we support OEM and private-label supply, including custom packaging, labeling and formulation assistance for finished-goods brands and distributors.
Standard packaging includes double-layer food-grade polyethylene bags in fiber drums or cartons (typically 1 kg, 5 kg, or 25 kg), with custom packaging sizes available on request.
MOQ varies by order form (sample, trial batch, or full container), typically starting from 1 kg for trial orders; please contact our sales team with your target quantity and destination for a formal quotation.
Documents are subject to product and batch availability; third-party reports are provided only when applicable.
Quality documents
The specification sheet defines acceptance limits. The COA shows actual batch results, which may vary by batch. Third-party reports are provided only for products or batches that have been independently tested.
Stable acceptance criteria · Available on request
Actual test data · Issued with each shipment
Technical Resources
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Alex Huang · Mon–Fri 9am–6pm CST
